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Trial registered on ANZCTR

Registration number
Ethics application status
Date submitted
Date registered
Date last updated
Type of registration
Retrospectively registered

Titles & IDs
Public title
Acute effect of resistance exercise on blood glucose levels in Type 1 diabetes
Scientific title
Acute effect of resistance exercise on blood glucose levels in Type 1 diabetes
Universal Trial Number (UTN)
Trial acronym
Linked study record

Health condition
Health condition(s) or problem(s) studied:
Type 1 diabetes 3304 0
Condition category
Condition code
Metabolic and Endocrine 3468 3468 0 0

Study type
Description of intervention(s) / exposure
Blood glucose is measured continuously during two 3-day periods. During one of these 3-day periods, a 1 hour resistance exercise session is performed consisting of the following exercises: Bench Press, Leg Extensions, Upright Row, Lateral Pull-downs, Dumbbell Flys, squats and abdominal crunches. During the other 3-day period no exercise is performed. Each participant acts as their own control and completes both 3-day periods with a minimum of 3 days washout in between.
Intervention code [1] 3045 0
Other interventions
Comparator / control treatment
No exercise.
Control group

Primary outcome [1] 4371 0
Blood glucose (measured continuously)
Timepoint [1] 4371 0
Baseline (pre-exercise/control), Day 1 (Exercise/Control session and following evening), Day 1 overnight, Day 2, Day 2 overnight, and Day 3.
Secondary outcome [1] 7376 0
Safety - post resistance exercise hypoglycemia. Hypoglycemic will be assesses by examining blood glucose levels following resistance exercise compared to rest. This will be measured from the continuous glucose monitor downloaded data.
Timepoint [1] 7376 0
Total time spent with blood glucose level below 3.5mmol/l in the 48 hours following resistance exercise compared to rest.

Key inclusion criteria
Type 1 diabetes
Minimum age
18 Years
Maximum age
45 Years
Both males and females
Can healthy volunteers participate?
Key exclusion criteria
History of hypoglycemic unawareness, untreated proliferative retinopathy, proteinuria, cardiovascular disease, any absolute exercise contraindications.

Study design
Purpose of the study
Allocation to intervention
Randomised controlled trial
Procedure for enrolling a subject and allocating the treatment (allocation concealment procedures)
A Treatment session (1-hour resistance exercise) and control (no exercise) is conducted by each participant during the two 3-day periods in random order. Order determined for each partciipant by random selection of sealed envelope containing order.
Methods used to generate the sequence in which subjects will be randomised (sequence generation)
Total of 16 envelopes - half sealed envelopes contained exercie/rest and half contained rest/exercise.
Masking / blinding
Open (masking not used)
Who is / are masked / blinded?

Intervention assignment
Other design features
Type of endpoint(s)
Statistical methods / analysis

Recruitment status
Date of first participant enrolment
Date of last participant enrolment
Date of last data collection
Sample size
Accrual to date
Recruitment in Australia
Recruitment state(s)

Funding & Sponsors
Funding source category [1] 3513 0
Commercial sector/Industry
Name [1] 3513 0
Novo Nordisk Regional Diabetes Support Scheme
Address [1] 3513 0
PO Box 862, Hawthorn, VIC 3122
Country [1] 3513 0
Funding source category [2] 3514 0
Commercial sector/Industry
Name [2] 3514 0
Medtronic Minimed
Address [2] 3514 0
Northridge, California
Country [2] 3514 0
United States of America
Primary sponsor type
Commercial sector/Industry
Novo Nordisk Regional Diabetes Support Scheme
PO Box 863, Hawthorn, VIC 3122
Secondary sponsor category [1] 3154 0
Name [1] 3154 0
International Diabetes Institute
Address [1] 3154 0
250 Kooyong Road, Caulfield, VIC 3162
Country [1] 3154 0

Ethics approval
Ethics application status
Ethics committee name [1] 5549 0
International Diabetes Institute Ethics Committee
Ethics committee address [1] 5549 0
c/- 250 Kooyong Road, Caulfield, VIC 3162
Ethics committee country [1] 5549 0
Date submitted for ethics approval [1] 5549 0
Approval date [1] 5549 0
Ethics approval number [1] 5549 0

Brief summary
Beneficial effects of moderate- to high- injtensity resistance exercise have been reported in Type 2 diabetes but there is little information available regarding the effects of resistance exercise in Type 1 diabetes. Therefore the purpose of this study is to examine the effects of an acute bout of moderate- to high- intensity resistance exercise on 48-hour blood glucose profiles in Type 1 diabetes using continuous glucose monitoring.
Trial website
Trial related presentations / publications
Public notes

Principal investigator
Name 28697 0
Address 28697 0
Country 28697 0
Phone 28697 0
Fax 28697 0
Email 28697 0
Contact person for public queries
Name 11854 0
Carol Robinson
Address 11854 0
International Diabetes Institute
250 Kooyong Road, Caulfield, VIC 3162
Country 11854 0
Phone 11854 0
(03) 9258 5075
Fax 11854 0
(03) 9258 5090
Email 11854 0
Contact person for scientific queries
Name 2782 0
Carol Robinson
Address 2782 0
International Diabetes Institute
250 Kooyong Road, Caulfield, VIC 3162
Country 2782 0
Phone 2782 0
(03) 9258 5075
Fax 2782 0
(03) 9258 5090
Email 2782 0

No information has been provided regarding IPD availability
Summary results
Have study results been published in a peer-reviewed journal?
Other publications
Have study results been made publicly available in another format?
Results – basic reporting
Results – plain English summary