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Trial registered on ANZCTR
Registration number
ACTRN12617001387314
Ethics application status
Approved
Date submitted
4/09/2017
Date registered
29/09/2017
Date last updated
26/08/2019
Date data sharing statement initially provided
26/08/2019
Type of registration
Retrospectively registered
Titles & IDs
Public title
National Echocardiography Database Australia (NEDA). A longitudinal cohort study of echocardiograms from public and private echocardiography laboratories from around Australia, linked with the National Deaths Index.
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Scientific title
National Echocardiography Database Australia (NEDA). A multicentre cohort longitudinal echocardiography study involving public and private echocardiography laboratories around Australia, assessing the prevalence and mortality of pulmonary hypertension and other cardiac abnormalities identified by echocardiography.
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Secondary ID [1]
292734
0
Nil Known
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Universal Trial Number (UTN)
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Trial acronym
NEDA
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Linked study record
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Health condition
Health condition(s) or problem(s) studied:
Cardiovascular Diseases
304501
0
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Pulmonary Hypertension
304502
0
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Condition category
Condition code
Cardiovascular
303838
303838
0
0
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Other cardiovascular diseases
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Cardiovascular
303839
303839
0
0
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Normal development and function of the cardiovascular system
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Respiratory
304138
304138
0
0
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Other respiratory disorders / diseases
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Intervention/exposure
Study type
Observational
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Patient registry
False
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Target follow-up duration
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Target follow-up type
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Description of intervention(s) / exposure
No intervention. Measurements and text interpretation information performed as part of a standard echo examination are collected from a backup copy of the echo database at each lab. The duration of the observation is from the first echo ever entered into the clinical database at the lab until the last echo entered when the backup database was taken. This time interval varies among each laboratory in Australia, and is dependent on when digital echocardiography was installed in the laboratory, and may be as long as 10 years. Since NEDA is a real world database, there is no intervention and no change to practice with NEDA.
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Intervention code [1]
298978
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Not applicable
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Comparator / control treatment
No control group
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Control group
Uncontrolled
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Outcomes
Primary outcome [1]
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Prevalence of pulmonary hypertension, defined by elevated pulmonary artery systolic pressure (PASP) >40mmHg measured by echocardiography, in a diverse Australian population.
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Assessment method [1]
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Timepoint [1]
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The true prevalence in our echo cohort will be the proportion of patients with pulmonary hypertension in NEDA. The minimum indicative prevalence of pulmonary hypertension will be measured by the prevalence of pulmonary hypertension in our cohort of echocardiography patients projected against the Australian population. The time period for the observation will be those having echocardiography within the last 2 years and still alive at the time of the data analysis.
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Primary outcome [2]
303203
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Prognosis of Pulmonary Hypertension as defined by Pulmonary Arterial Systolic Pressure (PASP) >= 40mmHg measured using echocardiography from within the NEDA cohort, matched against mortality, provided data linkage with the National Deaths Index.
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Assessment method [2]
303203
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Timepoint [2]
303203
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The time period for the observation will be those having echocardiography within the last 2 years and still alive at the time of the data analysis.
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Secondary outcome [1]
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The association between pulmonary artery systolic pressure and echo variables: left ventricular ejection fraction, mitral inflow E wave velocity, myocardial relaxation septal E’ velocity, E:E’ ratio, left atrial volume, right ventricular TAPSE, right ventricular basal and mid diameters, right ventricular Tei index, Noninvasive PVR estimation (Schiller equation), and right atrial volume.
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Assessment method [1]
338231
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Timepoint [1]
338231
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Each echo variable will be analysed against pulmonary artery systolic pressure using standard statistical analysis tools. The time period for the observation will be all echocardiograms in the NEDA database.
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Secondary outcome [2]
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Identification of additional echo parameters associated with markers of pulmonary hypertension disease severity and predictors of death. This is an exploratory analysis designed to identify those additional markers not identified as standard markers, and those not included in Secondary Outcome 1.
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Assessment method [2]
338232
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Timepoint [2]
338232
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The time period for the observation will be all echocardiograms in the NEDA database.
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Secondary outcome [3]
338233
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Identification of reference ranges for echocardiographic variables. Reference intervals refer to the normal ranges normally found in healthy individuals. Since NEDA is a "big data" database, it is well suited to analysis of subgroups such as those without any demonstrable disease. Each individual measurement (up to 150 individual variables) will be subjected to this analysis. Only variables in which valid conclusions can be drawn based on the number of available measurements will be reported.
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Assessment method [3]
338233
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Timepoint [3]
338233
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The time period for the observation will be all echocardiograms in the NEDA database.
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Eligibility
Key inclusion criteria
Participants will be considered those who have undergone echocardiography at one of the participating centres in accordance with standard clinical practice.
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Minimum age
18
Years
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Maximum age
No limit
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Sex
Both males and females
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Can healthy volunteers participate?
No
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Key exclusion criteria
Individuals under the age of 18 will be excluded from the study and those who withdraw their consent. There are no other exclusion criteria for participants involved in the study. Individual data points may be excluded if a clause is present in an echo study suggesting that image quality was insufficient for accurate diagnostic imaging to be performed.
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Study design
Purpose
Natural history
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Duration
Longitudinal
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Selection
Convenience sample
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Timing
Both
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Statistical methods / analysis
The planned sample size of 900,000 is based on 150 Australian
laboratories reporting an average of 3000 studies per year, with at least
one year of retrospective data available. This sample size will provide
good precision to estimate the prevalence of pulmonary hypertension, and the associated abnormalities of echocardiographic variables. Based on our previous data of an estimated median survival of 4.3+/-0.1 years for patients with all-cause pulmonary hypertension, a sample size of 779 PHT patients would be required to identify a characteristic associated with a 10% increase in risk, with power 80%, alpha level 0.05.
Since NEDA will have a vastly greater sample size than the necessary sample size for risk prediction described above, NEDA will be well powered to address the primary and secondary outcomes.
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Recruitment
Recruitment status
Recruiting
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Date of first participant enrolment
Anticipated
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Actual
5/01/2015
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Date of last participant enrolment
Anticipated
31/12/2020
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Actual
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Date of last data collection
Anticipated
31/12/2020
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Actual
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Sample size
Target
900000
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Accrual to date
500000
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Final
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Recruitment in Australia
Recruitment state(s)
ACT,NSW,NT,QLD,SA,TAS,WA,VIC
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Recruitment hospital [1]
8873
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Royal Prince Alfred Hospital - Camperdown
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Recruitment hospital [2]
8874
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Nepean Hospital - Kingswood
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Recruitment hospital [3]
8875
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Springwood Hospital - Springwood
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Recruitment hospital [4]
8876
0
Blue Mountains District ANZAC Memorial Hospital - Katoomba
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Recruitment hospital [5]
8877
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Hawkesbury District Health Service - Windsor
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Recruitment hospital [6]
8878
0
John Hunter Hospital - New Lambton
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Recruitment hospital [7]
8879
0
St Vincent's Private Hospital (Darlinghurst) - Darlinghurst
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Recruitment hospital [8]
8880
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Royal Darwin Hospital - Tiwi
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Recruitment hospital [9]
8881
0
Royal Hobart Hospital - Hobart
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Recruitment hospital [10]
8882
0
Sunshine Hospital - St Albans
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Recruitment hospital [11]
8883
0
Footscray Hospital - Footscray
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Recruitment hospital [12]
8884
0
Royal Perth Hospital - Perth
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Recruitment hospital [13]
8885
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Fiona Stanley Hospital - Murdoch
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Recruitment hospital [14]
8886
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Belmont Hospital - Belmont
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Recruitment hospital [15]
8887
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The Maitland Hospital - Maitland
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Recruitment hospital [16]
11765
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Barwon Health - Geelong Hospital campus - Geelong
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Recruitment hospital [17]
11766
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The Prince Charles Hospital - Chermside
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Recruitment hospital [18]
11767
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Blacktown Hospital - Blacktown
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Recruitment hospital [19]
11768
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Baker Heart and Diabetes Institute - Melbourne
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Recruitment hospital [20]
11769
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St Vincent's Hospital (Melbourne) Ltd - Fitzroy
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Recruitment hospital [21]
14624
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Westmead Hospital - Westmead
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Recruitment postcode(s) [1]
17130
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0810 - Tiwi
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Recruitment postcode(s) [2]
17129
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2010 - Darlinghurst
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Recruitment postcode(s) [3]
17123
0
2050 - Camperdown
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Recruitment postcode(s) [4]
27648
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2145 - Westmead
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Recruitment postcode(s) [5]
23862
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2148 - Blacktown
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Recruitment postcode(s) [6]
17136
0
2280 - Belmont
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Recruitment postcode(s) [7]
17128
0
2305 - New Lambton
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Recruitment postcode(s) [8]
17137
0
2320 - Maitland
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Recruitment postcode(s) [9]
17124
0
2747 - Kingswood
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Recruitment postcode(s) [10]
17127
0
2756 - Windsor
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Recruitment postcode(s) [11]
17125
0
2777 - Springwood
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Recruitment postcode(s) [12]
17126
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2780 - Katoomba
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Recruitment postcode(s) [13]
23863
0
3004 - Melbourne
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Recruitment postcode(s) [14]
17133
0
3011 - Footscray
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Recruitment postcode(s) [15]
17132
0
3021 - St Albans
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Recruitment postcode(s) [16]
23864
0
3065 - Fitzroy
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Recruitment postcode(s) [17]
23860
0
3220 - Geelong
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Recruitment postcode(s) [18]
23861
0
4032 - Chermside
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Recruitment postcode(s) [19]
17134
0
6000 - Perth
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Recruitment postcode(s) [20]
17135
0
6150 - Murdoch
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Recruitment postcode(s) [21]
17131
0
7000 - Hobart
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Funding & Sponsors
Funding source category [1]
297371
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Commercial sector/Industry
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Name [1]
297371
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Glaxo Smith-Kleine Pharmaceuticals
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Address [1]
297371
0
1061 Mountain Highway, Boronia Victoria 3155
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Country [1]
297371
0
Australia
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Funding source category [2]
297376
0
Commercial sector/Industry
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Name [2]
297376
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Actelion Pharmaceuticals
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Address [2]
297376
0
Ste 6/ 13B Narabang Way, Belrose New South Wales 2085
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Country [2]
297376
0
Australia
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Funding source category [3]
297377
0
Commercial sector/Industry
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Name [3]
297377
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Bayer Pharmaceuticals
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Address [3]
297377
0
875 Pacific Highway, Pymble New South Wales 2073
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Country [3]
297377
0
Australia
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Primary sponsor type
Charities/Societies/Foundations
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Name
NEDA Limited
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Address
Unit 41, Mount Medical Centre
146 Mounts Bay Road
Perth WA 6000
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Country
Australia
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Secondary sponsor category [1]
296354
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None
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Name [1]
296354
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Address [1]
296354
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Country [1]
296354
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Ethics approval
Ethics application status
Approved
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Ethics committee name [1]
298475
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University of Notre Dame
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Ethics committee address [1]
298475
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PO Box 1225 Fremantle, Western Australia 6959
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Ethics committee country [1]
298475
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Australia
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Date submitted for ethics approval [1]
298475
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18/08/2014
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Approval date [1]
298475
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13/10/2014
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Ethics approval number [1]
298475
0
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Ethics committee name [2]
298499
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Sydney Local Health District HREC
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Ethics committee address [2]
298499
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Royal Prince Alfred Hospital Camperdown NSW 2050
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Ethics committee country [2]
298499
0
Australia
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Date submitted for ethics approval [2]
298499
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27/10/2015
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Approval date [2]
298499
0
16/03/2016
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Ethics approval number [2]
298499
0
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Ethics committee name [3]
298501
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Australian Institute of Health and Welfare Ethics Committee
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Ethics committee address [3]
298501
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GPO Box 570 Canberra ACT 2601
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Ethics committee country [3]
298501
0
Australia
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Date submitted for ethics approval [3]
298501
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31/01/2016
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Approval date [3]
298501
0
03/06/2016
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Ethics approval number [3]
298501
0
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Ethics committee name [4]
298502
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Tasmanian Health and Medical Research Ethics Committee
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Ethics committee address [4]
298502
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University of Tasmania Private Bag 1 Hobart TAS 7001
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Ethics committee country [4]
298502
0
Australia
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Date submitted for ethics approval [4]
298502
0
21/03/2016
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Approval date [4]
298502
0
08/06/2016
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Ethics approval number [4]
298502
0
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Ethics committee name [5]
298504
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South Metropolitan Health Service HREC
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Ethics committee address [5]
298504
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Level 2, Southern Research Facility (Perkins building) Fiona Stanley Hospital, 11 Robin Warren Drive, MURDOCH WA 6150
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Ethics committee country [5]
298504
0
Australia
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Date submitted for ethics approval [5]
298504
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03/05/2016
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Approval date [5]
298504
0
21/07/2016
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Ethics approval number [5]
298504
0
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Ethics committee name [6]
298505
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Menzies School of Research HREC
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Ethics committee address [6]
298505
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PO BOX 41096 Casuarina NT 0811
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Ethics committee country [6]
298505
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Australia
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Date submitted for ethics approval [6]
298505
0
05/08/2016
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Approval date [6]
298505
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14/11/2016
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Ethics approval number [6]
298505
0
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Summary
Brief summary
Contemporary Australian data suggest that pulmonary hypertension (PHT) is more common than previously reported and confers a poor prognosis, however this single-centre data needs confirmation in a large population study from many locations and diverse backgrounds. Identification of underlying cause and prognosis of PHT non-invasively using simple markers would have a major impact on the diagnosis and management of patients with PHT. PHT is often identified during echocardiography, performed for investigation of breathlessness. PHT is not a diagnosis in itself, but has a number of underlying causes that require additional investigation to delineate. Such causes include left heart diseases, various chronic respiratory illnesses, and chronic thromboembolic and pulmonary vascular diseases. Over 900,000 echocardiograms (echos) are performed in Australia each year, but to date there has been no systematic method for capturing data from these echos. The newly developed National Echo Database Australia (NEDA) is designed to obtain measurement and report data, but no images, from digital echo laboratory across Australia and transfer them to a secure database, matched against national mortality data. The NEDA database will be the largest echo database in the world. Identification of the population of patients with PHT is of great importance, both to target those who may benefit from disease-specific therapy, and to better understand all forms of PHT in Australia and New Zealand. Abnormalities identifiable using echocardiography may be very useful prognostic indicators, and may help separate various causes for PHT. This information could be used to both identify patients who may respond to treatment, and to identify them earlier, with the goal of decreasing both morbidity and mortality for this common condition.
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Trial website
www.neda.net.au
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Trial related presentations / publications
Naing, P. et al., Performance of a Novel Echocardiographic Marker Against Right Heart Catheterisation in Identifying Pulmonary Hypertension due to Left Heart Disease, Heart, Lung and Circulation, 2017, Volume 26 (Supplement 2), S 269. Chung, K; Playford, D; Celermajer, D; Codde, J; Scalia, G; Strange, G; Pulmonary hypertension due to diastolic dysfunction: a predictive model using the national echo database of Australia (NEDA), European Heart Journal, Volume 38, Issue suppl 1, 1 August 2017, P2590. Playford et al. Making Australia the Benchmark in Echocardiography Databases: The National Echo Database Australia (NEDA). Pulmonary Circulation 2017;7(1):268. Chung, K et al, The National Echo Database Australia (NEDA) and pulmonary hypertension, Pulmonary Circulation 2017;7(1):273. Strange, G; Playford, D; Naing, P; Codde, J; Celermajer, D; Scalia, G, Chung, K; NEDA PH-LHD predictive model: validation of diastolic markers of pulmonary hypertension with right heart catheterisation, 6th World Symposium on Pulmonary Hypertension, Nice, France, February 27-28/March 1, 2018. Strange, G; Playford, D; Codde, J; Celermajer, D; Scalia, G; Chung, K; Pulmonary Hypertension (PH) due to left heart disease: a predictive model using the national echo database of Australia (NEDA), , 6th World Symposium on Pulmonary Hypertension, Nice, France, February 27-28/March 1, 2018. Chung, K. et al, NEDA PH-LHD predictive model: validation of diastolic markers of pulmonary hypertension with right heart catheterization, Pulmonary Circulation 2018; 8(2):1. Chung, K. et al, Pulmonary hypertension due to left heart disease: a predictive model using the National Echo Database of Australia (NEDA), Pulmonary Circulation 2018; 8(2):5. Playford, D; Bordin, E; Talbot, L; Mohamad, R; Anderson, B; Strange, G. Analysis of Aortic Stenosis using Artificial Intelligence, American Society of Echocardiography 28th Annual Scientific Sessions, 22-26 June 2018, Nashville USA. Journal of the American Society of Echocardiography, volume 31, B87. Chung, K; Strange, G; Naing, P; Celermajer, D; Codde, J; Scalia, GM; Playford, D. Assessing the Cause of Pulmonary Hypertension on Echo in the Absence of Tricuspid Regurgitation – a NEDA (National Echo Database of Australia) Study. American Society of Echocardiography 28th Annual Scientific Sessions, 22-26 June 2018, Nashville USA. Journal of the American Society of Echocardiography, volume 31, B87. Haghi, A; Stewart, S; Playford, D; Marwick, T; Celermajer, D; Prior, D; Scalia, G; Ilton, M; Strange, G.A Comparison of Long-Term Mortality Prediction Using Two Methods of EF Assessment from the National Echo Database Australia (NEDA) American Society of Echocardiography 28th Annual Scientific Sessions, 22-26 June 2018, Nashville USA. Journal of the American Society of Echocardiography, volume 31, B127. Naing, P; Hillis, GS; Scalia, G; Strange, G; Codde, J; Playford, D. Differentiating Pre-Capillary and Post-Capillary Pulmonary Hypertension by Doppler Echocardiography in a Large Real-World Database, American Society of Echocardiography 28th Annual Scientific Sessions, 22-26 June 2018, Nashville USA. Journal of the American Society of Echocardiography, volume 31, B79. Strange, G; Stewart, S; Celermajer, D; Marwick, T; Scalia, G; Prior, D; Ilton, M; Playford, D; Mortality from Aortic Stenosis Across the Spectrum of Severity: Analysis of Big Data from the National Echo Database of Australia (NEDA), American Society of Echocardiography 28th Annual Scientific Sessions, 22-26 June 2018, Nashville USA. Journal of the American Society of Echocardiography, volume 31, B52. Strange, G; Stewart, S; Celermajer, D; Marwick, T; Scalia, G; Prior, D; Ilton, M; Playford, D; Mortality from Aortic Stenosis Across the Spectrum of Severity: Analysis of Big Data from the National Echo Database of Australia, Abstracts for the 65th Cardiac Society of Australia and New Zealand Annual Scientific Meeting and the International Society for Heart Research Australasian Section Annual Scientific Meeting, 2018, Brisbane, Australia, Heart, Lung and Circulation, Volume 27, S256. Murphy, C; Playford, D; Stewart, S; Celermajer, D; Marwick, T; Strange, G; Mortality from Left Atrial Enlargement Based on Method of Measurement: Analysis of Big Data from the National Echo Database of Australia, Abstracts for the 65th Cardiac Society of Australia and New Zealand Annual Scientific Meeting and the International Society for Heart Research Australasian Section Annual Scientific Meeting, 2018, Brisbane, Australia, Heart, Lung and Circulation, Volume 27, S256. Playford, D; Bordin, E; Talbot, L; Mohamed, R; Anderson, B; Strange, G; Analysis of Aortic Stenosis Using Artificial Intelligence, Abstracts for the 65th Cardiac Society of Australia and New Zealand Annual Scientific Meeting and the International Society for Heart Research Australasian Section Annual Scientific Meeting, 2018, Brisbane, Australia, Heart, Lung and Circulation, Volume 27, S216. Haghi, A; Stewart, S; Playford, D; Celermajer, D; Prior, D; Scalia, G; Ilton, M; Strange, G; Comparison of Long-Term Mortality Prediction Using Two Methods of Ejection Fraction Assessment from the National Echo Database Australia, Abstracts for the 65th Cardiac Society of Australia and New Zealand Annual Scientific Meeting and the International Society for Heart Research Australasian Section Annual Scientific Meeting, 2018, Brisbane, Australia, Heart, Lung and Circulation, Volume 27, S208. Chung, K; Strange, G; Naing, P; Codde, J; Celermajer, D; Scalia, G; Playford, D; Assessing the cause of pulmonary hypertension on echo in the absence of tricuspid regurgitation - A NEDA (National Echo Database of Australia) study, European Heart Journal, Volume 39, Issue suppl 1, 1 August 2018, P454. Murphy, C; Playford, P; Stewart, S; Celermajer, D; Marwick, T; Strange, G; Mortality from left atrial enlargement based on method of measurement: analysis of big data from the national echo database of australia (NEDA), European Heart Journal, Volume 39, Issue suppl 1, 1 August 2018, 4133. Playford, D; Mohamad, R; Talbot, L; Bordin, E; Strange, G; Artificial intelligence (AI) and echocardiography: a training model using real world data for imputation of missing measurements, European Heart Journal, Volume 39, Issue suppl 1, 1 August 2018, P5631. Haghi, A; Stewart, S; Playford, D; Celermajer, D; Prior, D; Scalia, G; Ilton, M; G Strange; A comparison of long-term mortality prediction using two methods of EF assessment from the National Echo Database Australia (NEDA), European Heart Journal, Volume 39, Issue suppl 1, 1 August 2018, 6174. Strange G, Celermajer DS, Marwick T, Prior D, Ilton M, Codde J, et al. The National Echocardiography Database Australia (NEDA): Rationale and methodology. American Heart Journal 2018; Strange G, Stewart S, Celermajer DS, Prior D, Scalia G, Marwick M, Gabbay E, Ilton M, Joseph M, Codde J and Playford D. Increased mortality associated with borderline pulmonary hypertenion: Insights from the National Echocardiography Database of Australia. 13th PVRI Annual World Congress on Pulmonary Vascular Disease, January 2019, Barcelona, Spain. Strange G, Stewart S, Celermajer DS, Prior D, Scalia GM, Marwick TH, et al. Threshold of Pulmonary Hypertension Associated With Increased Mortality. J Am Coll Cardiol. 2019;73(21):2660–72. Maron, B.A. and Wertheim B. M. Toward early diagnosis of Pulmonary Hypertension: Lessons from Oz, J Am Coll Cardiol. 2019;73(21):2673–75.
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Public notes
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Contacts
Principal investigator
Name
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Prof David Playford
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Address
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School of Medicine
University of Notre Dame
32 Mouat Street,
Fremantle, WA 6959
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Country
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Australia
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Phone
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+61 8 9391 1234
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Fax
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Email
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dplayford@neda.net.au
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Contact person for public queries
Name
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Geoff Strange
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Address
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Cardiology
Royal Prince Alfred Hospital
Missenden Road
Camperdown NSW 2050
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Country
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Australia
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Phone
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+61 422 308 585
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Fax
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Email
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gstrange@neda.net.au
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Contact person for scientific queries
Name
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Geoff Strange
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Address
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Cardiology
Royal Prince Alfred Hospital
Missenden Road
Camperdown NSW 2050
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Country
77200
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Australia
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Phone
77200
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+ 61 422 308 585
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Fax
77200
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Email
77200
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gstrange@neda.net.au
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Data sharing statement
Will individual participant data (IPD) for this trial be available (including data dictionaries)?
No
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No/undecided IPD sharing reason/comment
All data will be aggregated and no individual data will be available.
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What supporting documents are/will be available?
No Supporting Document Provided
Results publications and other study-related documents
Documents added manually
No documents have been uploaded by study researchers.
Documents added automatically
Source
Title
Year of Publication
DOI
Embase
The National Echocardiography Database Australia (NEDA): Rationale and methodology.
2018
https://dx.doi.org/10.1016/j.ahj.2018.07.001
Embase
Threshold of Pulmonary Hypertension Associated With Increased Mortality.
2019
https://dx.doi.org/10.1016/j.jacc.2019.03.482
Embase
Enhanced Diagnosis of Severe Aortic Stenosis Using Artificial Intelligence: A Proof-of-Concept Study of 530,871 Echocardiograms.
2020
https://dx.doi.org/10.1016/j.jcmg.2019.10.013
Embase
Poor Survival with Impaired Valvular Hemodynamics After Aortic Valve Replacement: The National Echo Database Australia Study.
2020
https://dx.doi.org/10.1016/j.echo.2020.04.024
Embase
Change in ejection fraction and long-term mortality in adults referred for echocardiography.
2021
https://dx.doi.org/10.1002/ejhf.2161
Embase
Characteristics of bicuspid aortic valve disease and stenosis: The national echo database of Australia.
2021
https://dx.doi.org/10.1161/JAHA.121.020785
Embase
Ejection fraction and mortality: a nationwide register-based cohort study of 499 153 women and men.
2021
https://dx.doi.org/10.1002/ejhf.2047
Embase
Markers of Elevated Left Ventricular Filling Pressure Are Associated with Increased Mortality in Nonsevere Aortic Stenosis.
2021
https://dx.doi.org/10.1016/j.echo.2020.12.017
Embase
Preserved ejection fraction and structural heart disease in 446 848 patients investigated with echocardiography.
2021
https://dx.doi.org/10.1002/ehf2.13149
Embase
Prevalence and outcomes of low-gradient severe aortic stenosis-from the national echo database of Australia.
2021
https://dx.doi.org/10.1161/JAHA.121.021126
Embase
Prevalence, incidence and associates of pulmonary hypertension complicating type 2 diabetes: Insights from the fremantle diabetes study phase 2 and national echocardiographic database of Australia.
2021
https://dx.doi.org/10.3390/jcm10194503
Embase
Adverse Prognostic Impact of Even Mild or Moderate Tricuspid Regurgitation: Insights from the National Echocardiography Database of Australia.
2022
https://dx.doi.org/10.1016/j.echo.2022.04.003
Embase
Incident aortic stenosis in 49 449 men and 42 229 women investigated with routine echocardiography.
2022
https://dx.doi.org/10.1136/heartjnl-2021-319697
Embase
Prevalence and survival associated with pulmonary hypertension after mitral valve replacement: National echocardiography database of Australia study.
2022
https://dx.doi.org/10.1002/pul2.12140
Embase
Prevalence and prognostic impact of tricuspid regurgitation in patients with cardiac implantable electronic devices: From the national echocardiography database of Australia.
2023
https://dx.doi.org/10.1016/j.ijcard.2022.10.160
Embase
Prevalence of pulmonary hypertension in mitral regurgitation and its influence on outcomes.
2023
https://dx.doi.org/10.1136/openhrt-2023-002268
Embase
The association of resting heart rate with the development and progression of aortic stenosis.
2023
https://dx.doi.org/10.1093/ehjci/jead204
Embase
The prognostic significance of stroke volume index in low gradient severe aortic stenosis: from the national echo database of Australia.
2023
https://dx.doi.org/10.1007/s10554-023-02886-y
Embase
The Relationship between Pulmonary Artery Pressure and Mortality in Type 2 Diabetes: A Fremantle Diabetes Study Phase II and National Echocardiographic Database of Australia Data Linkage Study.
2023
https://dx.doi.org/10.3390/jcm12247685
Embase
The year 2022 in the European Heart Journal-Cardiovascular Imaging: Part I.
2023
https://dx.doi.org/10.1093/ehjci/jead237
Embase
Valvuloarterial Impedance and 5-Year Mortality in Severe Aortic Stenosis.
2023
https://dx.doi.org/10.14744/AnatolJCardiol.2022.2498
Dimensions AI
Incident pulmonary hypertension in 13 488 cases investigated with repeat echocardiography: a clinical cohort study
2023
https://doi.org/10.1183/23120541.00082-2023
N.B. These documents automatically identified may not have been verified by the study sponsor.
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