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Trial registered on ANZCTR

Registration number
Ethics application status
Date submitted
Date registered
Date last updated
Type of registration
Prospectively registered

Titles & IDs
Public title
Short-term exercise training and its effect on glucose tolerance and immune function.
Scientific title
Two weeks of moderate-intensity treadmill exercise and its effect on glucose tolerance and T regulatory cells in individuals with type 2 diabetes.
Secondary ID [1] 291245 0
Universal Trial Number (UTN)
Trial acronym
Linked study record

Health condition
Health condition(s) or problem(s) studied:
Type 2 Diabetes 302175 0
Condition category
Condition code
Metabolic and Endocrine 301784 301784 0 0
Inflammatory and Immune System 301785 301785 0 0
Other inflammatory or immune system disorders

Study type
Description of intervention(s) / exposure
Participants will complete moderate-intensity exercise on a treadmill.
Exercise will last for 45 minutes (moderate intensity at 65% of VO2peak) and will last for 12 sessions over a two-week period at the Murdoch University exercise physiology laboratory.

An oral glucose tolerance test will be completed pre and post-training with blood samples taken every 30 minutes. Blood samples will also be used to measure immune related cells such as regulatory T cells.

Familiarisation will preceed training with a VO2peak test, body composition analysis and anthropometrics measured.

Exercise will be supervised by the PhD student who is running the project.
Intervention code [1] 297251 0
Treatment: Other
Comparator / control treatment
Baseline measurements - pre-exercise training.
Control group

Primary outcome [1] 301185 0
Glucose tolerance via oral glucose tolerance test (75g glucose).
Participants will ingest a 75g-carbohydrate containing drink in a fasted state.
Timepoint [1] 301185 0
Pre and post two week training period.
Blood samples will be collected pre-ingestion and every 30 minutes for two hours.
Secondary outcome [1] 331973 0
Regulatory T cells will be assessed via flow cytometry from whole blood samples.
Timepoint [1] 331973 0
Blood samples will be collected prior to and immediately following the first and last exercise session of the training period.

Key inclusion criteria
Diagnosed as type 2 diabetic,
BMI > 27
Sedentary or low level of physical activity (1 or 2 bouts per week)
Minimum age
18 Years
Maximum age
65 Years
Both males and females
Can healthy volunteers participate?
Key exclusion criteria
Non-diabetic, healthy and active individuals.
BMI < 27

Study design
Purpose of the study
Allocation to intervention
Non-randomised trial
Procedure for enrolling a subject and allocating the treatment (allocation concealment procedures)
Methods used to generate the sequence in which subjects will be randomised (sequence generation)
Masking / blinding
Open (masking not used)
Who is / are masked / blinded?

Intervention assignment
Single group
Other design features
Not Applicable
Type of endpoint(s)
Statistical methods / analysis

Recruitment status
Not yet recruiting
Date of first participant enrolment
Date of last participant enrolment
Date of last data collection
Sample size
Accrual to date
Recruitment in Australia
Recruitment state(s)

Funding & Sponsors
Funding source category [1] 295698 0
Name [1] 295698 0
Murdoch University
Address [1] 295698 0
90 South Street, Murdoch 6150, Perth, Western Australia
Country [1] 295698 0
Primary sponsor type
Murdoch University
90 South Street, Murdoch 6150, Perth, Western Australia
Secondary sponsor category [1] 294547 0
Name [1] 294547 0
Address [1] 294547 0
Country [1] 294547 0

Ethics approval
Ethics application status
Ethics committee name [1] 297004 0
Murdoch University Human Ethics Committee
Ethics committee address [1] 297004 0
90 South St, Murdoch 6150, Perth, Western Australia
Ethics committee country [1] 297004 0
Date submitted for ethics approval [1] 297004 0
Approval date [1] 297004 0
Ethics approval number [1] 297004 0

Brief summary
Current evidence suggests exercise plays an important role in the management of blood glucose levels for individuals with T2DM. The frequency of consecutive exercise session over a two-week period on glucose regulation is not well understood and limited. Previous research have investigated either combined exercise or a single mode of exercise on glucose tolerance, However the comparison of 12 consecutive session of exercise remains limited, especially in a clinical population of type 2 diabetes. We seek to determine how effective treadmill exercise is in managing glucose tolerance since walking/running is freely accessible without the need to sign up to a gym. It is now understood that type 2 diabetes is associated with a chronic state of inflammation. Recent evidence have shown that exercise is beneficial in improving inflammation along with reducing insulin resistance. We aim to identify the influence of exercise on the level of inflammation and glucose tolerance following a two-week training period. Findings of this study may help inform future exercise prescription to improving health status in this population.
Trial website
Trial related presentations / publications
Public notes

Principal investigator
Name 72686 0
Mr Aaron Raman
Address 72686 0
Murdoch University,
90 South St
Murdoch 6150
Western Australia
Country 72686 0
Phone 72686 0
Fax 72686 0
Email 72686 0
Contact person for public queries
Name 72687 0
Mr Aaron Raman
Address 72687 0
Murdoch University,
90 South St
Murdoch 6150
Western Australia
Country 72687 0
Phone 72687 0
Fax 72687 0
Email 72687 0
Contact person for scientific queries
Name 72688 0
Mr Aaron Raman
Address 72688 0
Murdoch University,
90 South St
Murdoch 6150
Western Australia
Country 72688 0
Phone 72688 0
Fax 72688 0
Email 72688 0

No information has been provided regarding IPD availability
Summary results
No Results