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Trial details imported from ClinicalTrials.gov

For full trial details, please see the original record at https://clinicaltrials.gov/show/NCT00968708




Registration number
NCT00968708
Ethics application status
Date submitted
28/08/2009
Date registered
28/08/2009
Date last updated
15/04/2014

Titles & IDs
Public title
Cardiovascular Outcomes Study of Alogliptin in Patients With Type 2 Diabetes and Acute Coronary Syndrome
Scientific title
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate Cardiovascular Outcomes Following Treatment With Alogliptin in Addition to Standard of Care in Subjects With Type 2 Diabetes and Acute Coronary Syndrome
Secondary ID [1] 0 0
U1111-1111-6825
Secondary ID [2] 0 0
SYR-322_402
Universal Trial Number (UTN)
Trial acronym
EXAMINE
Linked study record

Health condition
Health condition(s) or problem(s) studied:
Diabetes Mellitus, Type 2 0 0
Acute Coronary Syndrome 0 0
Diabetes Mellitus, Type 2 0 0
Acute Coronary Syndrome 0 0
Diabetes Mellitus, Type 2 0 0
Acute Coronary Syndrome 0 0
Condition category
Condition code
Metabolic and Endocrine 0 0 0 0
Diabetes
Other 0 0 0 0
Research that is not of generic health relevance and not applicable to specific health categories listed above
Cardiovascular 0 0 0 0
Coronary heart disease

Intervention/exposure
Study type
Interventional
Description of intervention(s) / exposure
Treatment: Drugs - Alogliptin
Treatment: Drugs - Placebo
Treatment: Drugs - Alogliptin
Treatment: Drugs - Placebo
Treatment: Drugs - Alogliptin
Treatment: Drugs - Placebo

Experimental: Placebo - Alogliptin placebo matching tablets, orally, once daily. Participants continued to receive standard of care for cardiovascular disease and diabetes according to regional guidelines.

Experimental: Alogliptin - Alogliptin 25 mg, tablets, orally, once daily for participants with normal or mildly impaired renal function as defined by estimated glomerular filtration rate (eGFR) = 60 mL/min). Alogliptin 12.5 mg, tablets, orally, once daily for participants with moderately impaired renal function (eGFR =30 and <60 mL/min). Alogliptin 6.25 mg, tablets, orally, once daily for participants with severely impaired renal function or end stage renal disease (eGFR <30 mL/min). Participants continued to receive standard of care for cardiovascular disease and diabetes according to regional guidelines.

Experimental: Placebo - Alogliptin placebo matching tablets, orally, once daily. Participants continued to receive standard of care for cardiovascular disease and diabetes according to regional guidelines.

Experimental: Alogliptin - Alogliptin 25 mg, tablets, orally, once daily for participants with normal or mildly impaired renal function as defined by estimated glomerular filtration rate (eGFR) = 60 mL/min). Alogliptin 12.5 mg, tablets, orally, once daily for participants with moderately impaired renal function (eGFR =30 and <60 mL/min). Alogliptin 6.25 mg, tablets, orally, once daily for participants with severely impaired renal function or end stage renal disease (eGFR <30 mL/min). Participants continued to receive standard of care for cardiovascular disease and diabetes according to regional guidelines.

Experimental: Placebo - Alogliptin placebo matching tablets, orally, once daily. Participants continued to receive standard of care for cardiovascular disease and diabetes according to regional guidelines.

Experimental: Alogliptin - Alogliptin 25 mg, tablets, orally, once daily for participants with normal or mildly impaired renal function as defined by estimated glomerular filtration rate (eGFR) = 60 mL/min). Alogliptin 12.5 mg, tablets, orally, once daily for participants with moderately impaired renal function (eGFR =30 and <60 mL/min). Alogliptin 6.25 mg, tablets, orally, once daily for participants with severely impaired renal function or end stage renal disease (eGFR <30 mL/min). Participants continued to receive standard of care for cardiovascular disease and diabetes according to regional guidelines.


Treatment: Drugs: Alogliptin
Alogliptin tablets

Treatment: Drugs: Placebo
Alogliptin placebo matching tablets

Treatment: Drugs: Alogliptin
Alogliptin tablets

Treatment: Drugs: Placebo
Alogliptin placebo matching tablets

Treatment: Drugs: Alogliptin
Alogliptin tablets

Treatment: Drugs: Placebo
Alogliptin placebo matching tablets

Intervention code [1] 0 0
Treatment: Drugs
Comparator / control treatment
Control group

Outcomes
Primary outcome [1] 0 0
Percentage of Participants With Primary Major Adverse Cardiac Events (MACE) - Primary Major Adverse Cardiac Events were defined as a composite of cardiovascular death, nonfatal myocardial infarction and nonfatal stroke; these events were adjudicated by an independent cardiovascular endpoints committee.
Timepoint [1] 0 0
From randomization until the adjudication cut-off date of May 31 2013 (maximum time on study was 41 months).
Primary outcome [2] 0 0
Percentage of Participants With Primary Major Adverse Cardiac Events (MACE) - Primary Major Adverse Cardiac Events were defined as a composite of cardiovascular death, nonfatal myocardial infarction and nonfatal stroke; these events were adjudicated by an independent cardiovascular endpoints committee.
Timepoint [2] 0 0
From randomization until the adjudication cut-off date of May 31 2013 (maximum time on study was 41 months).
Primary outcome [3] 0 0
Percentage of Participants With Primary Major Adverse Cardiac Events (MACE) - Primary Major Adverse Cardiac Events were defined as a composite of cardiovascular death, nonfatal myocardial infarction and nonfatal stroke; these events were adjudicated by an independent cardiovascular endpoints committee.
Timepoint [3] 0 0
From randomization until the adjudication cut-off date of May 31 2013 (maximum time on study was 41 months).
Secondary outcome [1] 0 0
Percentage of Participants With Secondary Major Adverse Cardiac Events (MACE) - Secondary MACE composite consisted of cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, or urgent revascularization due to unstable angina; these events were adjudicated by an independent cardiovascular endpoint committee.
Timepoint [1] 0 0
From randomization until the adjudication cut-of date of May 31 2013 (maximum time on study was 41 months).
Secondary outcome [2] 0 0
Percentage of Participants With Secondary Major Adverse Cardiac Events (MACE) - Secondary MACE composite consisted of cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, or urgent revascularization due to unstable angina; these events were adjudicated by an independent cardiovascular endpoint committee.
Timepoint [2] 0 0
From randomization until the adjudication cut-of date of May 31 2013 (maximum time on study was 41 months).
Secondary outcome [3] 0 0
Percentage of Participants With Secondary Major Adverse Cardiac Events (MACE) - Secondary MACE composite consisted of cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, or urgent revascularization due to unstable angina; these events were adjudicated by an independent cardiovascular endpoint committee.
Timepoint [3] 0 0
From randomization until the adjudication cut-of date of May 31 2013 (maximum time on study was 41 months).

Eligibility
Key inclusion criteria
- Diagnosis of type 2 diabetes mellitus

- Is receiving monotherapy or combination antidiabetic therapy with a glycosylated
hemoglobin level between 6.5% and 11.0%, inclusive, at Screening (between 7.0 and
11.0%, inclusive, if the participant's antidiabetic regimen includes insulin)

- Diagnosis of acute coronary syndrome within 15 to 90 days prior to randomization.
Minimum age
18 Years
Maximum age
No limit
Gender
Both males and females
Can healthy volunteers participate?
No
Key exclusion criteria
- Signs of type 1 diabetes mellitus

- Currently receiving a glucagon-like peptide-1 analogue for glycemic control of type 2
diabetes mellitus at Screening

- Received a dipeptidyl peptidase-4 inhibitor for either more than 14 days total or
within the 3 months prior to Screening.

Study design
Purpose of the study
Treatment
Allocation to intervention
Randomised controlled trial
Procedure for enrolling a subject and allocating the treatment (allocation concealment procedures)
Methods used to generate the sequence in which subjects will be randomised (sequence generation)
Masking / blinding
Blinded (masking used)
Who is / are masked / blinded?
The people receiving the treatment/s
The people administering the treatment/s
The people assessing the outcomes
The people analysing the results/data
Intervention assignment
Parallel
Other design features
Phase
Phase 3
Type of endpoint(s)
Statistical methods / analysis

Recruitment
Recruitment status
Completed
Data analysis
Reason for early stopping/withdrawal
Other reasons
Date of first participant enrolment
Anticipated
Actual
Date of last participant enrolment
Anticipated
Actual
Date of last data collection
Anticipated
Actual
Sample size
Target
Accrual to date
Final
Recruitment in Australia
Recruitment state(s)
NSW,QLD,TAS,VIC
Recruitment hospital [1] 0 0
- Broken Hill
Recruitment hospital [2] 0 0
- Kogarah
Recruitment hospital [3] 0 0
- Milton
Recruitment hospital [4] 0 0
- Nambour
Recruitment hospital [5] 0 0
- Hobart
Recruitment hospital [6] 0 0
- Fitzroy
Recruitment hospital [7] 0 0
- Frankston
Recruitment hospital [8] 0 0
- Heidelberg
Recruitment hospital [9] 0 0
- Prahran
Recruitment hospital [10] 0 0
- Adelaide, SA
Recruitment hospital [11] 0 0
- Bruce
Recruitment postcode(s) [1] 0 0
- Broken Hill
Recruitment postcode(s) [2] 0 0
- Kogarah
Recruitment postcode(s) [3] 0 0
- Milton
Recruitment postcode(s) [4] 0 0
- Nambour
Recruitment postcode(s) [5] 0 0
- Hobart
Recruitment postcode(s) [6] 0 0
- Fitzroy
Recruitment postcode(s) [7] 0 0
- Frankston
Recruitment postcode(s) [8] 0 0
- Heidelberg
Recruitment postcode(s) [9] 0 0
- Prahran
Recruitment postcode(s) [10] 0 0
- Adelaide, SA
Recruitment postcode(s) [11] 0 0
- Bruce
Recruitment outside Australia
Country [1] 0 0
United States of America
State/province [1] 0 0
Alabama
Country [2] 0 0
United States of America
State/province [2] 0 0
Arizona
Country [3] 0 0
United States of America
State/province [3] 0 0
Arkansas
Country [4] 0 0
United States of America
State/province [4] 0 0
California
Country [5] 0 0
United States of America
State/province [5] 0 0
Colorado
Country [6] 0 0
United States of America
State/province [6] 0 0
Connecticut
Country [7] 0 0
United States of America
State/province [7] 0 0
District of Columbia
Country [8] 0 0
United States of America
State/province [8] 0 0
Florida
Country [9] 0 0
United States of America
State/province [9] 0 0
Georgia
Country [10] 0 0
United States of America
State/province [10] 0 0
Idaho
Country [11] 0 0
United States of America
State/province [11] 0 0
Illinois
Country [12] 0 0
United States of America
State/province [12] 0 0
Indiana
Country [13] 0 0
United States of America
State/province [13] 0 0
Iowa
Country [14] 0 0
United States of America
State/province [14] 0 0
Kansas
Country [15] 0 0
United States of America
State/province [15] 0 0
Kentucky
Country [16] 0 0
United States of America
State/province [16] 0 0
Louisiana
Country [17] 0 0
United States of America
State/province [17] 0 0
Maine
Country [18] 0 0
United States of America
State/province [18] 0 0
Maryland
Country [19] 0 0
United States of America
State/province [19] 0 0
Massachusetts
Country [20] 0 0
United States of America
State/province [20] 0 0
Michigan
Country [21] 0 0
United States of America
State/province [21] 0 0
Minnesota
Country [22] 0 0
United States of America
State/province [22] 0 0
Missouri
Country [23] 0 0
United States of America
State/province [23] 0 0
Montana
Country [24] 0 0
United States of America
State/province [24] 0 0
Nebraska
Country [25] 0 0
United States of America
State/province [25] 0 0
Nevada
Country [26] 0 0
United States of America
State/province [26] 0 0
New Jersey
Country [27] 0 0
United States of America
State/province [27] 0 0
New Mexico
Country [28] 0 0
United States of America
State/province [28] 0 0
New York
Country [29] 0 0
United States of America
State/province [29] 0 0
North Carolina
Country [30] 0 0
United States of America
State/province [30] 0 0
North Dakota
Country [31] 0 0
United States of America
State/province [31] 0 0
Ohio
Country [32] 0 0
United States of America
State/province [32] 0 0
Oklahoma
Country [33] 0 0
United States of America
State/province [33] 0 0
Oregon
Country [34] 0 0
United States of America
State/province [34] 0 0
Pennsylvania
Country [35] 0 0
United States of America
State/province [35] 0 0
Rhode Island
Country [36] 0 0
United States of America
State/province [36] 0 0
South Carolina
Country [37] 0 0
United States of America
State/province [37] 0 0
South Dakota
Country [38] 0 0
United States of America
State/province [38] 0 0
Tennessee
Country [39] 0 0
United States of America
State/province [39] 0 0
Texas
Country [40] 0 0
United States of America
State/province [40] 0 0
Utah
Country [41] 0 0
United States of America
State/province [41] 0 0
Vermont
Country [42] 0 0
United States of America
State/province [42] 0 0
Virginia
Country [43] 0 0
United States of America
State/province [43] 0 0
Washington
Country [44] 0 0
United States of America
State/province [44] 0 0
Wisconsin
Country [45] 0 0
Argentina
State/province [45] 0 0
Bahia Blanca
Country [46] 0 0
Argentina
State/province [46] 0 0
Buenos Aires
Country [47] 0 0
Argentina
State/province [47] 0 0
C0rdoba
Country [48] 0 0
Argentina
State/province [48] 0 0
Capital Federal, Buenos Aires
Country [49] 0 0
Argentina
State/province [49] 0 0
Capital Federal
Country [50] 0 0
Argentina
State/province [50] 0 0
Carlos Paz, C0rdoba
Country [51] 0 0
Argentina
State/province [51] 0 0
Ciudad Aut0noma de Buenos Aires
Country [52] 0 0
Argentina
State/province [52] 0 0
Ciudad Autonoma de Buenos Aires
Country [53] 0 0
Argentina
State/province [53] 0 0
Ciudad de C0rdoba
Country [54] 0 0
Argentina
State/province [54] 0 0
Cordoba - Cordoba
Country [55] 0 0
Argentina
State/province [55] 0 0
Cordoba
Country [56] 0 0
Argentina
State/province [56] 0 0
Corrientes
Country [57] 0 0
Argentina
State/province [57] 0 0
Derqui Pilar, Buenos Aires
Country [58] 0 0
Argentina
State/province [58] 0 0
Formosa
Country [59] 0 0
Argentina
State/province [59] 0 0
Haedo, Buenos Aires
Country [60] 0 0
Argentina
State/province [60] 0 0
La Plata, Buenos Aires
Country [61] 0 0
Argentina
State/province [61] 0 0
La Plata
Country [62] 0 0
Argentina
State/province [62] 0 0
Mar del Plata, Provincia de Buenos Aires
Country [63] 0 0
Argentina
State/province [63] 0 0
Mar del Plata
Country [64] 0 0
Argentina
State/province [64] 0 0
Mendoza
Country [65] 0 0
Argentina
State/province [65] 0 0
Moron, Buenos Aires
Country [66] 0 0
Argentina
State/province [66] 0 0
Olivos
Country [67] 0 0
Argentina
State/province [67] 0 0
Quilmes
Country [68] 0 0
Argentina
State/province [68] 0 0
Ramos Mejia, Buenos Aries
Country [69] 0 0
Argentina
State/province [69] 0 0
Ramos Mejia
Country [70] 0 0
Argentina
State/province [70] 0 0
Rosario - Santa Fe
Country [71] 0 0
Argentina
State/province [71] 0 0
Rosario, Provincia de Santa Fe
Country [72] 0 0
Argentina
State/province [72] 0 0
Rosario
Country [73] 0 0
Argentina
State/province [73] 0 0
Salta
Country [74] 0 0
Argentina
State/province [74] 0 0
San Isidro
Country [75] 0 0
Argentina
State/province [75] 0 0
San Juan, San Juan
Country [76] 0 0
Argentina
State/province [76] 0 0
San Justo
Country [77] 0 0
Argentina
State/province [77] 0 0
San Luis
Country [78] 0 0
Argentina
State/province [78] 0 0
San Miguel de Tucuman
Country [79] 0 0
Argentina
State/province [79] 0 0
San Salvador, de Jujuy
Country [80] 0 0
Argentina
State/province [80] 0 0
Santa Fe
Country [81] 0 0
Argentina
State/province [81] 0 0
Trelew, Chubut
Country [82] 0 0
Argentina
State/province [82] 0 0
Villa Maria
Country [83] 0 0
Austria
State/province [83] 0 0
Feldkirch
Country [84] 0 0
Austria
State/province [84] 0 0
Graz
Country [85] 0 0
Austria
State/province [85] 0 0
Salzburg
Country [86] 0 0
Austria
State/province [86] 0 0
Wien
Country [87] 0 0
Belgium
State/province [87] 0 0
Antwerpen
Country [88] 0 0
Belgium
State/province [88] 0 0
Bonheiden
Country [89] 0 0
Belgium
State/province [89] 0 0
Brasschaat
Country [90] 0 0
Belgium
State/province [90] 0 0
Brussel
Country [91] 0 0
Belgium
State/province [91] 0 0
Bruxelles
Country [92] 0 0
Belgium
State/province [92] 0 0
Gent
Country [93] 0 0
Belgium
State/province [93] 0 0
La Louviere
Country [94] 0 0
Brazil
State/province [94] 0 0
PR
Country [95] 0 0
Brazil
State/province [95] 0 0
RJ
Country [96] 0 0
Brazil
State/province [96] 0 0
SP
Country [97] 0 0
Brazil
State/province [97] 0 0
Aracaju, Sergipe
Country [98] 0 0
Brazil
State/province [98] 0 0
Belem - PA
Country [99] 0 0
Brazil
State/province [99] 0 0
Belo Horizonte - MG
Country [100] 0 0
Brazil
State/province [100] 0 0
Belo Horizonte, Minas Gerais
Country [101] 0 0
Brazil
State/province [101] 0 0
Blumenau
Country [102] 0 0
Brazil
State/province [102] 0 0
Brasilia - DF
Country [103] 0 0
Brazil
State/province [103] 0 0
Brasilia, Distrito Federal
Country [104] 0 0
Brazil
State/province [104] 0 0
Campina Grande do Sul
Country [105] 0 0
Brazil
State/province [105] 0 0
Campinas, Sao Paulo
Country [106] 0 0
Brazil
State/province [106] 0 0
Campo Grande, Mato Grosso do Sul
Country [107] 0 0
Brazil
State/province [107] 0 0
Curitiba, Parana
Country [108] 0 0
Brazil
State/province [108] 0 0
Fortaleza - CE
Country [109] 0 0
Brazil
State/province [109] 0 0
Fortaleza, Ceara
Country [110] 0 0
Brazil
State/province [110] 0 0
Goiania, Goias
Country [111] 0 0
Brazil
State/province [111] 0 0
Goiania
Country [112] 0 0
Brazil
State/province [112] 0 0
Joinville
Country [113] 0 0
Brazil
State/province [113] 0 0
Londrina/PR
Country [114] 0 0
Brazil
State/province [114] 0 0
Macei0
Country [115] 0 0
Brazil
State/province [115] 0 0
Marilia, Sao Paulo
Country [116] 0 0
Brazil
State/province [116] 0 0
Marilia
Country [117] 0 0
Brazil
State/province [117] 0 0
Mogi das Cruzes
Country [118] 0 0
Brazil
State/province [118] 0 0
Natal, RN
Country [119] 0 0
Brazil
State/province [119] 0 0
Natal
Country [120] 0 0
Brazil
State/province [120] 0 0
Passo Fundo, Rio Grande do Sul
Country [121] 0 0
Brazil
State/province [121] 0 0
Porto Alegre - RS
Country [122] 0 0
Brazil
State/province [122] 0 0
Porto Alegre, Rio Grande do Sul
Country [123] 0 0
Brazil
State/province [123] 0 0
Porto Alegre
Country [124] 0 0
Brazil
State/province [124] 0 0
Recife, Pernambuco
Country [125] 0 0
Brazil
State/province [125] 0 0
Recife, PE
Country [126] 0 0
Brazil
State/province [126] 0 0
Recife
Country [127] 0 0
Brazil
State/province [127] 0 0
Rio de Janeiro - RJ
Country [128] 0 0
Brazil
State/province [128] 0 0
Rio de Janeiro
Country [129] 0 0
Brazil
State/province [129] 0 0
Salvador - BA
Country [130] 0 0
Brazil
State/province [130] 0 0
Salvador, Bahia
Country [131] 0 0
Brazil
State/province [131] 0 0
Santo Andre
Country [132] 0 0
Brazil
State/province [132] 0 0
Sao Jose do Rio Preto, Sao Paulo
Country [133] 0 0
Brazil
State/province [133] 0 0
Sao Jose do Rio Preto- SP
Country [134] 0 0
Brazil
State/province [134] 0 0
Sao Jose do Rio Preto
Country [135] 0 0
Brazil
State/province [135] 0 0
Sao Jose, Santa Catarina
Country [136] 0 0
Brazil
State/province [136] 0 0
Sao Paulo, Sao Paulo
Country [137] 0 0
Brazil
State/province [137] 0 0
Sao Paulo, SP
Country [138] 0 0
Brazil
State/province [138] 0 0
Sao Paulo
Country [139] 0 0
Brazil
State/province [139] 0 0
Sobral, CE
Country [140] 0 0
Brazil
State/province [140] 0 0
Taguatinga
Country [141] 0 0
Brazil
State/province [141] 0 0
Uberlandia, Minas Gerais
Country [142] 0 0
Brazil
State/province [142] 0 0
Votuporanga
Country [143] 0 0
Bulgaria
State/province [143] 0 0
Blagoevgrad
Country [144] 0 0
Bulgaria
State/province [144] 0 0
Dimitrovgrad
Country [145] 0 0
Bulgaria
State/province [145] 0 0
Kazanlak
Country [146] 0 0
Bulgaria
State/province [146] 0 0
Lovech
Country [147] 0 0
Bulgaria
State/province [147] 0 0
Pleven
Country [148] 0 0
Bulgaria
State/province [148] 0 0
Plovdiv
Country [149] 0 0
Bulgaria
State/province [149] 0 0
Sevlievo
Country [150] 0 0
Bulgaria
State/province [150] 0 0
Smolian
Country [151] 0 0
Bulgaria
State/province [151] 0 0
Sofia
Country [152] 0 0
Bulgaria
State/province [152] 0 0
Stara Zagora
Country [153] 0 0
Bulgaria
State/province [153] 0 0
Varna
Country [154] 0 0
Canada
State/province [154] 0 0
Alberta
Country [155] 0 0
Canada
State/province [155] 0 0
British Columbia
Country [156] 0 0
Canada
State/province [156] 0 0
Newfoundland and Labrador
Country [157] 0 0
Canada
State/province [157] 0 0
Nova Scotia
Country [158] 0 0
Canada
State/province [158] 0 0
Ontario
Country [159] 0 0
Canada
State/province [159] 0 0
Quebec
Country [160] 0 0
Chile
State/province [160] 0 0
Antofagasta, Region II
Country [161] 0 0
Chile
State/province [161] 0 0
Antofagasta
Country [162] 0 0
Chile
State/province [162] 0 0
Iquique, Region I
Country [163] 0 0
Chile
State/province [163] 0 0
Osorno
Country [164] 0 0
Chile
State/province [164] 0 0
Rancagua
Country [165] 0 0
Chile
State/province [165] 0 0
Santiago
Country [166] 0 0
Chile
State/province [166] 0 0
Talcahuano
Country [167] 0 0
Chile
State/province [167] 0 0
Temuco, Region de la Araucania
Country [168] 0 0
Chile
State/province [168] 0 0
Temuco
Country [169] 0 0
Chile
State/province [169] 0 0
Vina del Mar
Country [170] 0 0
Colombia
State/province [170] 0 0
Barranquilla
Country [171] 0 0
Colombia
State/province [171] 0 0
Bogota
Country [172] 0 0
Colombia
State/province [172] 0 0
Bucaramanga
Country [173] 0 0
Colombia
State/province [173] 0 0
Medellin
Country [174] 0 0
Croatia
State/province [174] 0 0
Cakovec
Country [175] 0 0
Croatia
State/province [175] 0 0
Krapinske Toplice
Country [176] 0 0
Croatia
State/province [176] 0 0
Osijek
Country [177] 0 0
Croatia
State/province [177] 0 0
Rijeka
Country [178] 0 0
Croatia
State/province [178] 0 0
Sisak
Country [179] 0 0
Croatia
State/province [179] 0 0
Split
Country [180] 0 0
Croatia
State/province [180] 0 0
Virovitica
Country [181] 0 0
Croatia
State/province [181] 0 0
Zadar
Country [182] 0 0
Croatia
State/province [182] 0 0
Zagreb
Country [183] 0 0
Czech Republic
State/province [183] 0 0
Caslav
Country [184] 0 0
Czech Republic
State/province [184] 0 0
Hradec Kralove
Country [185] 0 0
Czech Republic
State/province [185] 0 0
Olomouc
Country [186] 0 0
Czech Republic
State/province [186] 0 0
Ostrava - Vitkovice
Country [187] 0 0
Czech Republic
State/province [187] 0 0
Zlin
Country [188] 0 0
Czech Republic
State/province [188] 0 0
Znojmo
Country [189] 0 0
Denmark
State/province [189] 0 0
Herlev
Country [190] 0 0
Denmark
State/province [190] 0 0
Herning
Country [191] 0 0
Denmark
State/province [191] 0 0
Kobenhavn NV
Country [192] 0 0
Egypt
State/province [192] 0 0
Alexandria
Country [193] 0 0
Egypt
State/province [193] 0 0
Giza
Country [194] 0 0
Egypt
State/province [194] 0 0
Monofia
Country [195] 0 0
Finland
State/province [195] 0 0
Helsinki
Country [196] 0 0
Finland
State/province [196] 0 0
Jyvaskyla
Country [197] 0 0
Finland
State/province [197] 0 0
Kokkola
Country [198] 0 0
Finland
State/province [198] 0 0
Kuopio
Country [199] 0 0
Finland
State/province [199] 0 0
Tampere
Country [200] 0 0
Finland
State/province [200] 0 0
Turku
Country [201] 0 0
France
State/province [201] 0 0
Bordeaux
Country [202] 0 0
France
State/province [202] 0 0
Corbeil Essonnes
Country [203] 0 0
France
State/province [203] 0 0
Corbeil-Essonnes
Country [204] 0 0
France
State/province [204] 0 0
Creteil
Country [205] 0 0
France
State/province [205] 0 0
Dijon
Country [206] 0 0
France
State/province [206] 0 0
La Rochelle
Country [207] 0 0
France
State/province [207] 0 0
Lille
Country [208] 0 0
France
State/province [208] 0 0
Montpellier
Country [209] 0 0
France
State/province [209] 0 0
Narbonne
Country [210] 0 0
France
State/province [210] 0 0
Paris
Country [211] 0 0
France
State/province [211] 0 0
Pau
Country [212] 0 0
France
State/province [212] 0 0
Pessac
Country [213] 0 0
France
State/province [213] 0 0
Rennes
Country [214] 0 0
France
State/province [214] 0 0
Toulouse
Country [215] 0 0
Germany
State/province [215] 0 0
Bad Nauheim
Country [216] 0 0
Germany
State/province [216] 0 0
Bensheim
Country [217] 0 0
Germany
State/province [217] 0 0
Berlin
Country [218] 0 0
Germany
State/province [218] 0 0
Dortmund
Country [219] 0 0
Germany
State/province [219] 0 0
Dresden
Country [220] 0 0
Germany
State/province [220] 0 0
Essen
Country [221] 0 0
Germany
State/province [221] 0 0
Halle (Saale)
Country [222] 0 0
Germany
State/province [222] 0 0
Jena
Country [223] 0 0
Germany
State/province [223] 0 0
Kassel
Country [224] 0 0
Germany
State/province [224] 0 0
Koln
Country [225] 0 0
Germany
State/province [225] 0 0
Leipzig
Country [226] 0 0
Germany
State/province [226] 0 0
Mainz
Country [227] 0 0
Germany
State/province [227] 0 0
Mannheim
Country [228] 0 0
Germany
State/province [228] 0 0
Muenchen
Country [229] 0 0
Germany
State/province [229] 0 0
Munster
Country [230] 0 0
Germany
State/province [230] 0 0
Neumuenster
Country [231] 0 0
Germany
State/province [231] 0 0
Neuwied
Country [232] 0 0
Germany
State/province [232] 0 0
Sankt Ingbert
Country [233] 0 0
Germany
State/province [233] 0 0
Siegen
Country [234] 0 0
Germany
State/province [234] 0 0
Wangen
Country [235] 0 0
Greece
State/province [235] 0 0
Marousi
Country [236] 0 0
Guatemala
State/province [236] 0 0
Guatemala City
Country [237] 0 0
Guatemala
State/province [237] 0 0
Guatemala
Country [238] 0 0
Guatemala
State/province [238] 0 0
Quetzaltenango
Country [239] 0 0
Hong Kong
State/province [239] 0 0
Hong Kong
Country [240] 0 0
Hong Kong
State/province [240] 0 0
Kowloon
Country [241] 0 0
Hong Kong
State/province [241] 0 0
Shatin
Country [242] 0 0
Hong Kong
State/province [242] 0 0
Tsuen Wan
Country [243] 0 0
Hungary
State/province [243] 0 0
Budaors
Country [244] 0 0
Hungary
State/province [244] 0 0
Budapest
Country [245] 0 0
Hungary
State/province [245] 0 0
Debrecen
Country [246] 0 0
Hungary
State/province [246] 0 0
Dunaujvaros
Country [247] 0 0
Hungary
State/province [247] 0 0
Gyula
Country [248] 0 0
Hungary
State/province [248] 0 0
H0dmezovasarhely
Country [249] 0 0
Hungary
State/province [249] 0 0
Kaposvar
Country [250] 0 0
Hungary
State/province [250] 0 0
Kecskemet
Country [251] 0 0
Hungary
State/province [251] 0 0
Nagykanizsa
Country [252] 0 0
Hungary
State/province [252] 0 0
Pecs
Country [253] 0 0
Hungary
State/province [253] 0 0
Sopron
Country [254] 0 0
Hungary
State/province [254] 0 0
Szekesfehervar
Country [255] 0 0
Hungary
State/province [255] 0 0
Szentes
Country [256] 0 0
Hungary
State/province [256] 0 0
Szombathely
Country [257] 0 0
Hungary
State/province [257] 0 0
Zalaegerszeg
Country [258] 0 0
India
State/province [258] 0 0
Andhra Pradesh
Country [259] 0 0
India
State/province [259] 0 0
Chennai
Country [260] 0 0
India
State/province [260] 0 0
Delhi
Country [261] 0 0
India
State/province [261] 0 0
Gujarat
Country [262] 0 0
India
State/province [262] 0 0
Karnataka
Country [263] 0 0
India
State/province [263] 0 0
Kerala
Country [264] 0 0
India
State/province [264] 0 0
Maharashtra
Country [265] 0 0
India
State/province [265] 0 0
Punjab
Country [266] 0 0
India
State/province [266] 0 0
Rajasthan
Country [267] 0 0
India
State/province [267] 0 0
Tamil Nadu
Country [268] 0 0
India
State/province [268] 0 0
West Bengal
Country [269] 0 0
Israel
State/province [269] 0 0
Ashkelon
Country [270] 0 0
Israel
State/province [270] 0 0
Beer Sheva
Country [271] 0 0
Israel
State/province [271] 0 0
Haifa
Country [272] 0 0
Israel
State/province [272] 0 0
Holon
Country [273] 0 0
Israel
State/province [273] 0 0
Jerusalem
Country [274] 0 0
Israel
State/province [274] 0 0
Kfar-Saba
Country [275] 0 0
Israel
State/province [275] 0 0
Nahariya
Country [276] 0 0
Israel
State/province [276] 0 0
Nazareth
Country [277] 0 0
Israel
State/province [277] 0 0
Petach Tikva
Country [278] 0 0
Israel
State/province [278] 0 0
Rehovot
Country [279] 0 0
Israel
State/province [279] 0 0
Rishon Lezion
Country [280] 0 0
Israel
State/province [280] 0 0
Safed
Country [281] 0 0
Israel
State/province [281] 0 0
Tel Aviv
Country [282] 0 0
Israel
State/province [282] 0 0
Tiberias
Country [283] 0 0
Italy
State/province [283] 0 0
Cosenza
Country [284] 0 0
Italy
State/province [284] 0 0
Isernia
Country [285] 0 0
Italy
State/province [285] 0 0
Milano
Country [286] 0 0
Italy
State/province [286] 0 0
Napoli
Country [287] 0 0
Italy
State/province [287] 0 0
Palermo
Country [288] 0 0
Italy
State/province [288] 0 0
Pavia
Country [289] 0 0
Italy
State/province [289] 0 0
Ravenna
Country [290] 0 0
Italy
State/province [290] 0 0
Roma
Country [291] 0 0
Italy
State/province [291] 0 0
Sesto San Giovanni
Country [292] 0 0
Japan
State/province [292] 0 0
Aichi
Country [293] 0 0
Japan
State/province [293] 0 0
Chiba
Country [294] 0 0
Japan
State/province [294] 0 0
Ehime
Country [295] 0 0
Japan
State/province [295] 0 0
Fukuoka
Country [296] 0 0
Japan
State/province [296] 0 0
Fukushima
Country [297] 0 0
Japan
State/province [297] 0 0
Gifu
Country [298] 0 0
Japan
State/province [298] 0 0
Gunma
Country [299] 0 0
Japan
State/province [299] 0 0
Hiroshima
Country [300] 0 0
Japan
State/province [300] 0 0
Hokkaido
Country [301] 0 0
Japan
State/province [301] 0 0
Hyogo
Country [302] 0 0
Japan
State/province [302] 0 0
Ishikawa
Country [303] 0 0
Japan
State/province [303] 0 0
Kagawa
Country [304] 0 0
Japan
State/province [304] 0 0
Kanagawa
Country [305] 0 0
Japan
State/province [305] 0 0
Kochi
Country [306] 0 0
Japan
State/province [306] 0 0
Kumamoto
Country [307] 0 0
Japan
State/province [307] 0 0
Kyoto
Country [308] 0 0
Japan
State/province [308] 0 0
Mie
Country [309] 0 0
Japan
State/province [309] 0 0
Nagasaki
Country [310] 0 0
Japan
State/province [310] 0 0
Oita
Country [311] 0 0
Japan
State/province [311] 0 0
Okayama
Country [312] 0 0
Japan
State/province [312] 0 0
Okinawa
Country [313] 0 0
Japan
State/province [313] 0 0
Osaka
Country [314] 0 0
Japan
State/province [314] 0 0
Saitama
Country [315] 0 0
Japan
State/province [315] 0 0
Shimane
Country [316] 0 0
Japan
State/province [316] 0 0
Shizuoka
Country [317] 0 0
Japan
State/province [317] 0 0
Tokushima
Country [318] 0 0
Japan
State/province [318] 0 0
Tokyo
Country [319] 0 0
Japan
State/province [319] 0 0
Yamaguchi
Country [320] 0 0
Japan
State/province [320] 0 0
Niigata
Country [321] 0 0
Japan
State/province [321] 0 0
Saga
Country [322] 0 0
Korea, Republic of
State/province [322] 0 0
Anyang
Country [323] 0 0
Korea, Republic of
State/province [323] 0 0
Busan
Country [324] 0 0
Korea, Republic of
State/province [324] 0 0
Daegu
Country [325] 0 0
Korea, Republic of
State/province [325] 0 0
Goyang-Si
Country [326] 0 0
Korea, Republic of
State/province [326] 0 0
Guri
Country [327] 0 0
Korea, Republic of
State/province [327] 0 0
Gyeonggi-do
Country [328] 0 0
Korea, Republic of
State/province [328] 0 0
Jeonju-si
Country [329] 0 0
Korea, Republic of
State/province [329] 0 0
Kangwon-do
Country [330] 0 0
Korea, Republic of
State/province [330] 0 0
Pusan
Country [331] 0 0
Korea, Republic of
State/province [331] 0 0
Seoul
Country [332] 0 0
Korea, Republic of
State/province [332] 0 0
Suwon
Country [333] 0 0
Korea, Republic of
State/province [333] 0 0
Yangsan
Country [334] 0 0
Kuwait
State/province [334] 0 0
Dasman
Country [335] 0 0
Latvia
State/province [335] 0 0
Daugavpils
Country [336] 0 0
Latvia
State/province [336] 0 0
Ogre
Country [337] 0 0
Latvia
State/province [337] 0 0
Riga
Country [338] 0 0
Latvia
State/province [338] 0 0
Tukums
Country [339] 0 0
Latvia
State/province [339] 0 0
Valmiera
Country [340] 0 0
Lithuania
State/province [340] 0 0
Kaunas
Country [341] 0 0
Lithuania
State/province [341] 0 0
Kedainiai
Country [342] 0 0
Lithuania
State/province [342] 0 0
Klaipeda
Country [343] 0 0
Lithuania
State/province [343] 0 0
Palanga
Country [344] 0 0
Lithuania
State/province [344] 0 0
Panevezys
Country [345] 0 0
Lithuania
State/province [345] 0 0
Vilnius
Country [346] 0 0
Malaysia
State/province [346] 0 0
Alor Setar
Country [347] 0 0
Malaysia
State/province [347] 0 0
Batu Caves
Country [348] 0 0
Malaysia
State/province [348] 0 0
Georgetown
Country [349] 0 0
Malaysia
State/province [349] 0 0
Kuala Lumpur
Country [350] 0 0
Malaysia
State/province [350] 0 0
Kuantan
Country [351] 0 0
Malaysia
State/province [351] 0 0
Kubang Kerian
Country [352] 0 0
Malaysia
State/province [352] 0 0
Pulau Pinang
Country [353] 0 0
Malaysia
State/province [353] 0 0
Selangor
Country [354] 0 0
Mexico
State/province [354] 0 0
Acapulco, Guerrero
Country [355] 0 0
Mexico
State/province [355] 0 0
Aguascalientes
Country [356] 0 0
Mexico
State/province [356] 0 0
Chihuahua
Country [357] 0 0
Mexico
State/province [357] 0 0
Chihuhua, Chihuhua
Country [358] 0 0
Mexico
State/province [358] 0 0
Ciudad Obregon, Sonora
Country [359] 0 0
Mexico
State/province [359] 0 0
Cuernavaca, Morelos
Country [360] 0 0
Mexico
State/province [360] 0 0
Cuernavaca
Country [361] 0 0
Mexico
State/province [361] 0 0
Culiacan
Country [362] 0 0
Mexico
State/province [362] 0 0
Durango
Country [363] 0 0
Mexico
State/province [363] 0 0
Guadalajara, Jalisco
Country [364] 0 0
Mexico
State/province [364] 0 0
Guadalajara
Country [365] 0 0
Mexico
State/province [365] 0 0
Merida, Yucatan
Country [366] 0 0
Mexico
State/province [366] 0 0
Metepec
Country [367] 0 0
Mexico
State/province [367] 0 0
Mexicali, Baja California
Country [368] 0 0
Mexico
State/province [368] 0 0
Mexico City, Mexico
Country [369] 0 0
Mexico
State/province [369] 0 0
Mexico City
Country [370] 0 0
Mexico
State/province [370] 0 0
Mexico
Country [371] 0 0
Mexico
State/province [371] 0 0
Monclova, Coahuila
Country [372] 0 0
Mexico
State/province [372] 0 0
Monterrey, NL
Country [373] 0 0
Mexico
State/province [373] 0 0
Monterrey, Nuevo Le0n
Country [374] 0 0
Mexico
State/province [374] 0 0
Monterrey, Nuevo Leon
Country [375] 0 0
Mexico
State/province [375] 0 0
Monterrey
Country [376] 0 0
Mexico
State/province [376] 0 0
Morelia, Michoacan
Country [377] 0 0
Mexico
State/province [377] 0 0
Pachuca
Country [378] 0 0
Mexico
State/province [378] 0 0
Saltillo, Coahuila
Country [379] 0 0
Mexico
State/province [379] 0 0
Saltillo
Country [380] 0 0
Mexico
State/province [380] 0 0
San Luis Potosi.SLP
Country [381] 0 0
Mexico
State/province [381] 0 0
San Luis Potosi
Country [382] 0 0
Mexico
State/province [382] 0 0
Tijuana, Baja California Norte
Country [383] 0 0
Mexico
State/province [383] 0 0
Tlalnepantla, Edo de Mexico
Country [384] 0 0
Mexico
State/province [384] 0 0
Tlalnepantla
Country [385] 0 0
Mexico
State/province [385] 0 0
Xalapa, Veracruz
Country [386] 0 0
Mexico
State/province [386] 0 0
Zapopan
Country [387] 0 0
New Zealand
State/province [387] 0 0
Auckland
Country [388] 0 0
New Zealand
State/province [388] 0 0
Christchurch
Country [389] 0 0
New Zealand
State/province [389] 0 0
Otahuhu
Country [390] 0 0
New Zealand
State/province [390] 0 0
Palmerston North
Country [391] 0 0
New Zealand
State/province [391] 0 0
Takapuna
Country [392] 0 0
New Zealand
State/province [392] 0 0
Tauranga
Country [393] 0 0
Peru
State/province [393] 0 0
Arequipa
Country [394] 0 0
Peru
State/province [394] 0 0
Bellavista
Country [395] 0 0
Peru
State/province [395] 0 0
Callao
Country [396] 0 0
Peru
State/province [396] 0 0
Cusco
Country [397] 0 0
Peru
State/province [397] 0 0
Huacho
Country [398] 0 0
Peru
State/province [398] 0 0
Ica
Country [399] 0 0
Peru
State/province [399] 0 0
La Victoria, Lima
Country [400] 0 0
Peru
State/province [400] 0 0
Lima San Isidro
Country [401] 0 0
Peru
State/province [401] 0 0
Lima
Country [402] 0 0
Peru
State/province [402] 0 0
Los Olivos
Country [403] 0 0
Peru
State/province [403] 0 0
Miraflores, Lima
Country [404] 0 0
Peru
State/province [404] 0 0
Piura
Country [405] 0 0
Peru
State/province [405] 0 0
San Isidro, Lima
Country [406] 0 0
Peru
State/province [406] 0 0
San Miguel, Lima
Country [407] 0 0
Peru
State/province [407] 0 0
Trujillo, La Libertad
Country [408] 0 0
Peru
State/province [408] 0 0
Trujillo
Country [409] 0 0
Philippines
State/province [409] 0 0
Baguio
Country [410] 0 0
Philippines
State/province [410] 0 0
Dasmarinas
Country [411] 0 0
Philippines
State/province [411] 0 0
Davao City
Country [412] 0 0
Philippines
State/province [412] 0 0
Iloilo City
Country [413] 0 0
Philippines
State/province [413] 0 0
Laoag City
Country [414] 0 0
Philippines
State/province [414] 0 0
Makati City
Country [415] 0 0
Philippines
State/province [415] 0 0
Manila
Country [416] 0 0
Philippines
State/province [416] 0 0
Marikina City
Country [417] 0 0
Philippines
State/province [417] 0 0
Pasig City
Country [418] 0 0
Philippines
State/province [418] 0 0
Quezon City
Country [419] 0 0
Poland
State/province [419] 0 0
Bialystok
Country [420] 0 0
Poland
State/province [420] 0 0
Bydgoszcz
Country [421] 0 0
Poland
State/province [421] 0 0
Czestochowa
Country [422] 0 0
Poland
State/province [422] 0 0
Dabrowa Gornicza
Country [423] 0 0
Poland
State/province [423] 0 0
Elblag
Country [424] 0 0
Poland
State/province [424] 0 0
Gdansk
Country [425] 0 0
Poland
State/province [425] 0 0
Gdynia
Country [426] 0 0
Poland
State/province [426] 0 0
Grodzisk Mazowiecki
Country [427] 0 0
Poland
State/province [427] 0 0
Inowroclaw
Country [428] 0 0
Poland
State/province [428] 0 0
Katowice
Country [429] 0 0
Poland
State/province [429] 0 0
Kielce
Country [430] 0 0
Poland
State/province [430] 0 0
Krakow
Country [431] 0 0
Poland
State/province [431] 0 0
Legnica
Country [432] 0 0
Poland
State/province [432] 0 0
Lodz
Country [433] 0 0
Poland
State/province [433] 0 0
Lubartow
Country [434] 0 0
Poland
State/province [434] 0 0
Lublin
Country [435] 0 0
Poland
State/province [435] 0 0
Plock
Country [436] 0 0
Poland
State/province [436] 0 0
Pulawy
Country [437] 0 0
Poland
State/province [437] 0 0
Radom
Country [438] 0 0
Poland
State/province [438] 0 0
Ruda Slaska
Country [439] 0 0
Poland
State/province [439] 0 0
Skierniewice
Country [440] 0 0
Poland
State/province [440] 0 0
Slupsk
Country [441] 0 0
Poland