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Trial details imported from ClinicalTrials.gov
For full trial details, please see the original record at
https://clinicaltrials.gov/study/NCT05021835
Registration number
NCT05021835
Ethics application status
Date submitted
19/08/2021
Date registered
26/08/2021
Date last updated
25/09/2025
Titles & IDs
Public title
ZEUS - A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Cardiovascular Disease, Chronic Kidney Disease and Inflammation
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Scientific title
ZEUS - Effects of Ziltivekimab Versus Placebo on Cardiovascular Outcomes in Participants With Established Atherosclerotic Cardiovascular Disease, Chronic Kidney Disease and Systemic Inflammation
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Secondary ID [1]
0
0
U1111-1259-3422
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Secondary ID [2]
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0
EX6018-4758
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Universal Trial Number (UTN)
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Trial acronym
ZEUS
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Linked study record
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Health condition
Health condition(s) or problem(s) studied:
Cardiovascular Risk
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0
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Chronic Kidney Disease
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0
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Inflammation
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0
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Condition category
Condition code
Renal and Urogenital
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0
0
0
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Other renal and urogenital disorders
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Intervention/exposure
Study type
Interventional
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Description of intervention(s) / exposure
Treatment: Drugs - Ziltivekimab B
Treatment: Drugs - Ziltivekimab C
Treatment: Drugs - Placebo (Ziltivekimab B)
Treatment: Drugs - Placebo (Ziltivekimab C)
Experimental: Ziltivekimab - Participants will receive Ziltivekimab B or Ziltivekimab C subcutaneously once monthly for up to 4 years.
Placebo comparator: Placebo - Participants will receive either placebo (Ziltivekimab B) or placebo (Ziltivekimab C) subcutaneously once monthly for up to 4 years.
Treatment: Drugs: Ziltivekimab B
Administered subcutaneously (s.c., under skin) once-monthly added to standard of care.
Treatment: Drugs: Ziltivekimab C
Administered subcutaneously (s.c., under skin) once-monthly added to standard of care.
Treatment: Drugs: Placebo (Ziltivekimab B)
Administered subcutaneously (s.c., under skin) once-monthly added to standard of care.
Treatment: Drugs: Placebo (Ziltivekimab C)
Administered subcutaneously (s.c., under skin) once-monthly added to standard of care.
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Intervention code [1]
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0
Treatment: Drugs
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Comparator / control treatment
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Control group
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Outcomes
Primary outcome [1]
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Time to first occurrence of 3-point Major Adverse Cardiovascular Event (MACE), a composite endpoint consisting of: Cardiovascular (CV) death, non-fatal Myocardial Infarction (MI) and non-fatal stroke
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Assessment method [1]
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Months
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Timepoint [1]
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From randomisation (month 0) to end-of-study (up to 48 months)
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Secondary outcome [1]
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Time to first occurrence of expanded MACE, a composite endpoint consisting of: CV death, non-fatal MI, non-fatal stroke and hospitalisation for unstable angina pectoris requiring urgent coronary revascularisation
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Assessment method [1]
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Months
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Timepoint [1]
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From randomisation (month 0) to end-of-study (up to 48 months)
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Secondary outcome [2]
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Number of heart failure hospitalisations or urgent heart failure visits or CV deaths
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Assessment method [2]
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Count
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Timepoint [2]
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0
From randomisation (month 0) to end-of-study (up to 48 months)
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Secondary outcome [3]
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Time to first occurrence of a composite kidney endpoint consisting of: CV death, onset of persistent atleast 40 percent (%) reduction in eGFR (CKD-epidemiology collaboration [CKD-EPI]) compared with baseline, kidney failure
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Assessment method [3]
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0
Months
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Timepoint [3]
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0
From randomisation (month 0) to end-of-study (up to 48 months)
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Secondary outcome [4]
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0
Time to occurrence of all-cause mortality
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Assessment method [4]
0
0
Months
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Timepoint [4]
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0
From randomisation (month 0) to end-of-study (up to 48 months)
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Secondary outcome [5]
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Time to first occurrence of each of the individual components of the expanded MACE endpoint and the kidney composite endpoint.
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Assessment method [5]
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0
Months
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Timepoint [5]
0
0
From randomisation (month 0) to end-of-study (up to 48 months).
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Secondary outcome [6]
0
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Time to first occurrence of MI (fatal and non-fatal).
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Assessment method [6]
0
0
Months
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Timepoint [6]
0
0
From randomisation (month 0) to end-of-study (up to 48 months).
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Secondary outcome [7]
0
0
Time to first occurrence of stroke (fatal and non-fatal).
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Assessment method [7]
0
0
Months
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Timepoint [7]
0
0
From randomisation (month 0) to end-of-study (up to 48 months).
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Secondary outcome [8]
0
0
Time to first occurrence of a composite MACE endpoint consisting of: all-cause mortality, non-fatal MI and non-fatal stroke
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Assessment method [8]
0
0
Months
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Timepoint [8]
0
0
From randomisation (month 0) to end-of-study (up to 48 months).
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Secondary outcome [9]
0
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Time to first occurrence of a 4-component kidney endpoint consisting of: onset of persistent at least 40% reduction in eGFR (CKD-EPI) compared with baseline, kidney failure
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Assessment method [9]
0
0
Months
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Timepoint [9]
0
0
From randomisation (month 0) to end-of-study (up to 48 months).
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Secondary outcome [10]
0
0
Time to first occurrence of coronary revascularisation
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Assessment method [10]
0
0
Months
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Timepoint [10]
0
0
From randomisation (month 0) to end-of-study (up to 48 months).
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Secondary outcome [11]
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Change in Urinary Abumin-to-Ceatinine ratio (UACR).
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Assessment method [11]
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Percentage
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Timepoint [11]
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0
From randomisation (month 0) to 2 years (24 months).
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Secondary outcome [12]
0
0
Change in eGFR (CKD-EPI))
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Assessment method [12]
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mL/min/1.73 m\^2
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Timepoint [12]
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From randomisation (month 0) to 2 years (24 months)
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Secondary outcome [13]
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Annual rate of change in eGFR (CKD-EPI) (total eGFR slope)
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Assessment method [13]
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mL/min/1.73 m\^2/ year
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Timepoint [13]
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From randomisation (month 0) to end-of-study (up to 48 months).
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Secondary outcome [14]
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Change in high-sensitivity C-reactive protein (hs-CRP)
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Assessment method [14]
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Percentage
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Timepoint [14]
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From randomisation (month 0) to 2 years (24 months
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Secondary outcome [15]
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Change in N-terminal-pro-brain natriuretic peptide ( NT-pro-BNP)
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Assessment method [15]
0
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Percentage
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Timepoint [15]
0
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From randomisation (month 0) to 2 years (24 months)
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Secondary outcome [16]
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Change in left ventricular ejection fraction (LVEF)
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Assessment method [16]
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Percentage
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Timepoint [16]
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From randomisation (month 0) to 2 years (24 months)
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Secondary outcome [17]
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Number of events of atrial fibrillation
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Assessment method [17]
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Count
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Timepoint [17]
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From randomisation (month 0) to end-of-study (up to 48 months).
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Secondary outcome [18]
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Change in haemoglobin
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Assessment method [18]
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Grams per deciliter (g/dL)
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Timepoint [18]
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From randomisation (month 0) to 2 years (24 months)
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Secondary outcome [19]
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Number of hospitalisations with infection as primary cause or death due to infection.
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Assessment method [19]
0
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Count
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Timepoint [19]
0
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From randomisation (month 0) to end-of-study (up to 48 months).
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Secondary outcome [20]
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Change in Short Form 36 (SF-36) Physical Component Score (PCS)
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Assessment method [20]
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Score on scale
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Timepoint [20]
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From randomisation (month 0) to 2 years (24 months)
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Eligibility
Key inclusion criteria
* Chronic kidney disease defined by one of the below:
1. Estimated glomerular filtration rate (eGFR) greater than or equal to (>=) 15 and below 60 mL/min/1.73 m^2 (using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine equation)
2. Urinary albumin-to-creatinine ratio (UACR) >= 200 milligrams per gram (mg/g) and eGFR >= 60 mL/min/1.73 m2 (using the CKD-EPI creatinine equation)
* Serum high-sensitivity C-reactive protein (hs-CRP) greater than or equal to 2 milligram per liter (mg/L)
* Evidence of atherosclerotic cardiovascular disease (ASCVD) by one or more of the following:
a) Coronary heart disease defined as at least one of the following: i. Documented history of MI ii. Prior coronary revascularisation procedure iii. greater than or equal to 50% stenosis in major epicardial coronary artery documented by cardiac catheterisation or CT coronary angiography b) Cerebrovascular disease defined as at least one of the following: i. Prior stroke of atherosclerotic origin ii. Prior carotid artery revascularisation procedure iii. greater than or equal to 50% stenosis in carotid artery documented by X-ray angiography, MR angiography, CT angiography or Doppler ultrasound.
c) Symptomatic peripheral artery disease (PAD) defined as at least one of the following: i. Intermittent claudication with an ankle-brachial index (ABI) below or equal to 0.90 at rest ii. Intermittent claudication with a greater than or equal to 50% stenosis in peripheral artery (excluding carotid) documented by X-ray angiography, MR angiography, CT angiography or Doppler ultrasound iii. Prior peripheral artery (excluding carotid) revascularisation procedure iv. Lower extremity amputation at or above ankle due to atherosclerotic disease (excluding e.g. trauma or osteomyelitis).
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Minimum age
18
Years
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Maximum age
No limit
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Sex
Both males and females
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Can healthy volunteers participate?
No
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Key exclusion criteria
* Clinical evidence of, or suspicion of, active infection at the discretion of the investigator.
* Myocardial infarction, stroke, hospitalisation for unstable angina pectoris, or transient ischaemic attack within 60 days prior to randomisation (visit 2).
* Planned coronary, carotid or peripheral artery revascularisation known on the day of randomisation (visit 2).
* Major cardiac surgical, non-cardiac surgical, or major endoscopic procedure (thoracoscopic or laparoscopic) within the past 60 days prior to randomisation (visit 2) or any major surgical procedure planned at the time of randomisation (visit 2).
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Study design
Purpose of the study
Treatment
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Allocation to intervention
Randomised controlled trial
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Procedure for enrolling a subject and allocating the treatment (allocation concealment procedures)
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Methods used to generate the sequence in which subjects will be randomised (sequence generation)
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Masking / blinding
Blinded (masking used)
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Who is / are masked / blinded?
The people receiving the treatment/s
The people administering the treatment/s
The people assessing the outcomes
The people analysing the results/data
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Intervention assignment
Parallel
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Other design features
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Phase
Phase 3
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Type of endpoint/s
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Statistical methods / analysis
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Recruitment
Recruitment status
Active, not recruiting
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Data analysis
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Reason for early stopping/withdrawal
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Other reasons
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Date of first participant enrolment
Anticipated
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Actual
30/08/2021
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Date of last participant enrolment
Anticipated
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Actual
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Date of last data collection
Anticipated
26/06/2026
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Actual
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Sample size
Target
6200
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Accrual to date
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Final
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Recruitment in Australia
Recruitment state(s)
ACT,NSW,QLD,SA,VIC,WA
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Recruitment hospital [1]
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0
The Canberra Hospital_Garran - Garran
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Recruitment hospital [2]
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Gosford Renal Research - Gosford
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Recruitment hospital [3]
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St George Hospital - Kogarah
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Recruitment hospital [4]
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Westmead Applied Research Centre - Westmead
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Recruitment hospital [5]
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Illawarra Heart Health Centre - Wollongong
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Recruitment hospital [6]
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Core Research Centre - Milton
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Recruitment hospital [7]
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Nightingale Research - Adelaide
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Recruitment hospital [8]
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Royal Adelaide Hospital Cardiovascular Clinical Trials - Adelaide
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Recruitment hospital [9]
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HeartCare SA - Leabrook
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Recruitment hospital [10]
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Monash Health Heart - Clayton
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Recruitment hospital [11]
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St Vincent's Hospital_Fitzroy_0 - Fitzroy
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Recruitment hospital [12]
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Geelong Cardiology Research Unit - Geelong
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Recruitment hospital [13]
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Melbourne Renal Research Group - Reservoir
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Recruitment hospital [14]
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Sunshine Hospital - St Albans
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Recruitment hospital [15]
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La Trobe Regional Hospital - Traralagon
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Recruitment hospital [16]
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HeartCare WA (Joondalup) - Joondalup
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Recruitment postcode(s) [1]
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2605 - Garran
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Recruitment postcode(s) [2]
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2250 - Gosford
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Recruitment postcode(s) [3]
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2217 - Kogarah
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Recruitment postcode(s) [4]
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2145 - Westmead
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Recruitment postcode(s) [5]
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2500 - Wollongong
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Recruitment postcode(s) [6]
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4064 - Milton
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Recruitment postcode(s) [7]
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5000 - Adelaide
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Recruitment postcode(s) [8]
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5068 - Leabrook
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Recruitment postcode(s) [9]
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3168 - Clayton
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Recruitment postcode(s) [10]
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3065 - Fitzroy
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Recruitment postcode(s) [11]
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3220 - Geelong
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Recruitment postcode(s) [12]
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3073 - Reservoir
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Recruitment postcode(s) [13]
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3021 - St Albans
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Recruitment postcode(s) [14]
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3844 - Traralagon
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Recruitment postcode(s) [15]
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6027 - Joondalup
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Recruitment outside Australia
Country [1]
0
0
United States of America
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State/province [1]
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Alabama
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Country [2]
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United States of America
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State/province [2]
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Arizona
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United States of America
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State/province [3]
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Arkansas
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United States of America
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California
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Country [5]
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United States of America
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State/province [5]
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Connecticut
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Country [6]
0
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United States of America
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State/province [6]
0
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District of Columbia
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Country [7]
0
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United States of America
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State/province [7]
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Florida
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Country [8]
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United States of America
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State/province [8]
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Georgia
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United States of America
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State/province [9]
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Idaho
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United States of America
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State/province [10]
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Illinois
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Country [11]
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State/province [11]
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Indiana
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Country [12]
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State/province [12]
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Kansas
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Country [13]
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State/province [13]
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Kentucky
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Country [14]
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United States of America
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State/province [14]
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Louisiana
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Country [15]
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State/province [15]
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Maryland
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Country [16]
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Massachusetts
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Michigan
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Minnesota
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Missouri
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Nebraska
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Nevada
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New Jersey
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New Mexico
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New York
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North Carolina
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North Dakota
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Ohio
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Pennsylvania
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South Carolina
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Tennessee
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Texas
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Virginia
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Washington
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Wisconsin
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Argentina
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State/province [35]
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Buenos Aires
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Argentina
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Ciudad Autónoma de Buenos Aire
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Argentina
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Córdoba
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0
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Argentina
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State/province [38]
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Quilmes - Buenos Aires
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Argentina
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State/province [39]
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San Miguel de Tucumán, Tucumán.
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Country [40]
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Argentina
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State/province [40]
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San Nicolás
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0
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Belgium
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Aalst
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Belgium
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Bonheiden
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Belgium
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Brasschaat
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Belgium
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Bruges
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Belgium
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Genk
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Belgium
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Kortrijk
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Belgium
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Liège
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0
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Belgium
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Mechelen
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0
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Belgium
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Ostend
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0
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Brazil
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Espírito Santo
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Brazil
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Federal District
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Brazil
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Minas Gerais
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0
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Brazil
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Paraná
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0
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Brazil
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Santa Catarina
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0
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Brazil
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São Paulo
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0
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Brazil
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Porto Alegre/ RS
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0
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Brazil
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Salvador
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Country [58]
0
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Brazil
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State/province [58]
0
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São Bernardo Do Campo/SP
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Country [59]
0
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Brazil
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State/province [59]
0
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São Paulo - SP
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Country [60]
0
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Bulgaria
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State/province [60]
0
0
Dimitrovgrad
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Country [61]
0
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Bulgaria
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State/province [61]
0
0
Kyustendil
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Country [62]
0
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Bulgaria
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State/province [62]
0
0
Pernik
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Country [63]
0
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Bulgaria
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State/province [63]
0
0
Pleven
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Country [64]
0
0
Bulgaria
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State/province [64]
0
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Plovdiv
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Country [65]
0
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Bulgaria
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State/province [65]
0
0
Sliven
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Country [66]
0
0
Bulgaria
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State/province [66]
0
0
Sofia
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Country [67]
0
0
Bulgaria
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State/province [67]
0
0
Stara Zagora
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Country [68]
0
0
Bulgaria
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State/province [68]
0
0
Varna
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Country [69]
0
0
Bulgaria
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State/province [69]
0
0
Yambol
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Country [70]
0
0
Canada
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State/province [70]
0
0
Alberta
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Country [71]
0
0
Canada
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State/province [71]
0
0
British Columbia
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Country [72]
0
0
Canada
Query!
State/province [72]
0
0
Nova Scotia
Query!
Country [73]
0
0
Canada
Query!
State/province [73]
0
0
Ontario
Query!
Country [74]
0
0
Canada
Query!
State/province [74]
0
0
Quebec
Query!
Country [75]
0
0
Canada
Query!
State/province [75]
0
0
Québec
Query!
Country [76]
0
0
China
Query!
State/province [76]
0
0
Anhui
Query!
Country [77]
0
0
China
Query!
State/province [77]
0
0
Beijing Municipality
Query!
Country [78]
0
0
China
Query!
State/province [78]
0
0
Chongqing Municipality
Query!
Country [79]
0
0
China
Query!
State/province [79]
0
0
Gansu
Query!
Country [80]
0
0
China
Query!
State/province [80]
0
0
Guangdong
Query!
Country [81]
0
0
China
Query!
State/province [81]
0
0
Guangxi
Query!
Country [82]
0
0
China
Query!
State/province [82]
0
0
Hainan
Query!
Country [83]
0
0
China
Query!
State/province [83]
0
0
Hebei
Query!
Country [84]
0
0
China
Query!
State/province [84]
0
0
Henan
Query!
Country [85]
0
0
China
Query!
State/province [85]
0
0
Hubei
Query!
Country [86]
0
0
China
Query!
State/province [86]
0
0
Hunan
Query!
Country [87]
0
0
China
Query!
State/province [87]
0
0
Jiangsu
Query!
Country [88]
0
0
China
Query!
State/province [88]
0
0
Jiangxi
Query!
Country [89]
0
0
China
Query!
State/province [89]
0
0
Jilin
Query!
Country [90]
0
0
China
Query!
State/province [90]
0
0
Liaoning
Query!
Country [91]
0
0
China
Query!
State/province [91]
0
0
Shaanxi
Query!
Country [92]
0
0
China
Query!
State/province [92]
0
0
Shandong
Query!
Country [93]
0
0
China
Query!
State/province [93]
0
0
Shanghai Municipality
Query!
Country [94]
0
0
China
Query!
State/province [94]
0
0
Shanxi
Query!
Country [95]
0
0
China
Query!
State/province [95]
0
0
Sichuan
Query!
Country [96]
0
0
China
Query!
State/province [96]
0
0
Tianjin Municipality
Query!
Country [97]
0
0
China
Query!
State/province [97]
0
0
Yunnan
Query!
Country [98]
0
0
China
Query!
State/province [98]
0
0
Zhejiang
Query!
Country [99]
0
0
China
Query!
State/province [99]
0
0
Beijing
Query!
Country [100]
0
0
China
Query!
State/province [100]
0
0
Changde
Query!
Country [101]
0
0
China
Query!
State/province [101]
0
0
Chengdu
Query!
Country [102]
0
0
China
Query!
State/province [102]
0
0
Guangzhou
Query!
Country [103]
0
0
China
Query!
State/province [103]
0
0
Hangzhou
Query!
Country [104]
0
0
China
Query!
State/province [104]
0
0
Huizhou
Query!
Country [105]
0
0
China
Query!
State/province [105]
0
0
Jinan
Query!
Country [106]
0
0
China
Query!
State/province [106]
0
0
Shantou
Query!
Country [107]
0
0
China
Query!
State/province [107]
0
0
Shenyang
Query!
Country [108]
0
0
Croatia
Query!
State/province [108]
0
0
City of Zagreb
Query!
Country [109]
0
0
Croatia
Query!
State/province [109]
0
0
Krapinsko Zagorska County
Query!
Country [110]
0
0
Croatia
Query!
State/province [110]
0
0
Rijeka
Query!
Country [111]
0
0
Croatia
Query!
State/province [111]
0
0
Zagreb
Query!
Country [112]
0
0
Czechia
Query!
State/province [112]
0
0
Broumov
Query!
Country [113]
0
0
Czechia
Query!
State/province [113]
0
0
Liberec
Query!
Country [114]
0
0
Czechia
Query!
State/province [114]
0
0
Náchod
Query!
Country [115]
0
0
Czechia
Query!
State/province [115]
0
0
Prague
Query!
Country [116]
0
0
Czechia
Query!
State/province [116]
0
0
Slaný
Query!
Country [117]
0
0
Denmark
Query!
State/province [117]
0
0
Aalborg
Query!
Country [118]
0
0
Denmark
Query!
State/province [118]
0
0
Aarhus N
Query!
Country [119]
0
0
Denmark
Query!
State/province [119]
0
0
Herning
Query!
Country [120]
0
0
Denmark
Query!
State/province [120]
0
0
Hvidovre
Query!
Country [121]
0
0
Denmark
Query!
State/province [121]
0
0
Kolding
Query!
Country [122]
0
0
Denmark
Query!
State/province [122]
0
0
Roskilde
Query!
Country [123]
0
0
Denmark
Query!
State/province [123]
0
0
Svendborg
Query!
Country [124]
0
0
Germany
Query!
State/province [124]
0
0
Baden-Wurttemberg
Query!
Country [125]
0
0
Germany
Query!
State/province [125]
0
0
Holstein
Query!
Country [126]
0
0
Germany
Query!
State/province [126]
0
0
Thuringia
Query!
Country [127]
0
0
Germany
Query!
State/province [127]
0
0
Aachen
Query!
Country [128]
0
0
Germany
Query!
State/province [128]
0
0
Dessau
Query!
Country [129]
0
0
Germany
Query!
State/province [129]
0
0
Dresden
Query!
Country [130]
0
0
Germany
Query!
State/province [130]
0
0
Düsseldorf
Query!
Country [131]
0
0
Germany
Query!
State/province [131]
0
0
Elsterwerda
Query!
Country [132]
0
0
Germany
Query!
State/province [132]
0
0
Essen
Query!
Country [133]
0
0
Germany
Query!
State/province [133]
0
0
Falkensee
Query!
Country [134]
0
0
Germany
Query!
State/province [134]
0
0
Frankfurt
Query!
Country [135]
0
0
Germany
Query!
State/province [135]
0
0
Homburg
Query!
Country [136]
0
0
Germany
Query!
State/province [136]
0
0
Jena
Query!
Country [137]
0
0
Germany
Query!
State/province [137]
0
0
Lübeck
Query!
Country [138]
0
0
Germany
Query!
State/province [138]
0
0
Mainz
Query!
Country [139]
0
0
Germany
Query!
State/province [139]
0
0
Reichelsheim
Query!
Country [140]
0
0
Germany
Query!
State/province [140]
0
0
Witten
Query!
Country [141]
0
0
Greece
Query!
State/province [141]
0
0
Attica
Query!
Country [142]
0
0
Greece
Query!
State/province [142]
0
0
Alexandroupoli
Query!
Country [143]
0
0
Greece
Query!
State/province [143]
0
0
Athens
Query!
Country [144]
0
0
Greece
Query!
State/province [144]
0
0
Chios
Query!
Country [145]
0
0
Greece
Query!
State/province [145]
0
0
Heraklion
Query!
Country [146]
0
0
Greece
Query!
State/province [146]
0
0
Ioannina
Query!
Country [147]
0
0
Greece
Query!
State/province [147]
0
0
Kifissia
Query!
Country [148]
0
0
Greece
Query!
State/province [148]
0
0
Lamia
Query!
Country [149]
0
0
Greece
Query!
State/province [149]
0
0
Larissa
Query!
Country [150]
0
0
Greece
Query!
State/province [150]
0
0
Rio, Patra
Query!
Country [151]
0
0
Greece
Query!
State/province [151]
0
0
Thessaloniki
Query!
Country [152]
0
0
Hungary
Query!
State/province [152]
0
0
Bekes County
Query!
Country [153]
0
0
Hungary
Query!
State/province [153]
0
0
Komárom-Esztergom
Query!
Country [154]
0
0
Hungary
Query!
State/province [154]
0
0
Zala County
Query!
Country [155]
0
0
Hungary
Query!
State/province [155]
0
0
Baja
Query!
Country [156]
0
0
Hungary
Query!
State/province [156]
0
0
Balatonfüred
Query!
Country [157]
0
0
Hungary
Query!
State/province [157]
0
0
Budapest
Query!
Country [158]
0
0
Hungary
Query!
State/province [158]
0
0
Debrecen
Query!
Country [159]
0
0
Hungary
Query!
State/province [159]
0
0
Szeged
Query!
Country [160]
0
0
India
Query!
State/province [160]
0
0
Andhra Pradesh
Query!
Country [161]
0
0
India
Query!
State/province [161]
0
0
Gujarat
Query!
Country [162]
0
0
India
Query!
State/province [162]
0
0
Karnataka
Query!
Country [163]
0
0
India
Query!
State/province [163]
0
0
Karnatka
Query!
Country [164]
0
0
India
Query!
State/province [164]
0
0
Kerala
Query!
Country [165]
0
0
India
Query!
State/province [165]
0
0
Maharashtra
Query!
Country [166]
0
0
India
Query!
State/province [166]
0
0
National Capital Territory of Delhi
Query!
Country [167]
0
0
India
Query!
State/province [167]
0
0
New Delhi
Query!
Country [168]
0
0
India
Query!
State/province [168]
0
0
Punjab
Query!
Country [169]
0
0
India
Query!
State/province [169]
0
0
Telangana
Query!
Country [170]
0
0
India
Query!
State/province [170]
0
0
Uttar Pradesh
Query!
Country [171]
0
0
India
Query!
State/province [171]
0
0
Jaipur
Query!
Country [172]
0
0
India
Query!
State/province [172]
0
0
Palakkad
Query!
Country [173]
0
0
Israel
Query!
State/province [173]
0
0
Holon
Query!
Country [174]
0
0
Israel
Query!
State/province [174]
0
0
Jerusalem
Query!
Country [175]
0
0
Israel
Query!
State/province [175]
0
0
Nahariya
Query!
Country [176]
0
0
Israel
Query!
State/province [176]
0
0
Petah Tikva
Query!
Country [177]
0
0
Israel
Query!
State/province [177]
0
0
Rehovot
Query!
Country [178]
0
0
Israel
Query!
State/province [178]
0
0
Tel Aviv
Query!
Country [179]
0
0
Israel
Query!
State/province [179]
0
0
Tel Litwinsky
Query!
Country [180]
0
0
Italy
Query!
State/province [180]
0
0
Cz
Query!
Country [181]
0
0
Italy
Query!
State/province [181]
0
0
Fe
Query!
Country [182]
0
0
Italy
Query!
State/province [182]
0
0
Lombardy
Query!
Country [183]
0
0
Italy
Query!
State/province [183]
0
0
Bologna
Query!
Country [184]
0
0
Italy
Query!
State/province [184]
0
0
Chieti Scalo
Query!
Country [185]
0
0
Italy
Query!
State/province [185]
0
0
Florence
Query!
Country [186]
0
0
Italy
Query!
State/province [186]
0
0
Genova
Query!
Country [187]
0
0
Italy
Query!
State/province [187]
0
0
Milan
Query!
Country [188]
0
0
Italy
Query!
State/province [188]
0
0
Montichiari
Query!
Country [189]
0
0
Italy
Query!
State/province [189]
0
0
Napoli
Query!
Country [190]
0
0
Italy
Query!
State/province [190]
0
0
Palermo
Query!
Country [191]
0
0
Italy
Query!
State/province [191]
0
0
Pavia
Query!
Country [192]
0
0
Italy
Query!
State/province [192]
0
0
Pisa
Query!
Country [193]
0
0
Italy
Query!
State/province [193]
0
0
Roma
Query!
Country [194]
0
0
Italy
Query!
State/province [194]
0
0
Rome
Query!
Country [195]
0
0
Italy
Query!
State/province [195]
0
0
Trieste
Query!
Country [196]
0
0
Italy
Query!
State/province [196]
0
0
Verona
Query!
Country [197]
0
0
Japan
Query!
State/province [197]
0
0
Ehime
Query!
Country [198]
0
0
Japan
Query!
State/province [198]
0
0
Fukushima, Japan
Query!
Country [199]
0
0
Japan
Query!
State/province [199]
0
0
Kumamoto, Japan
Query!
Country [200]
0
0
Japan
Query!
State/province [200]
0
0
Miyazaki
Query!
Country [201]
0
0
Japan
Query!
State/province [201]
0
0
Bunkyo-ku, Tokyo
Query!
Country [202]
0
0
Japan
Query!
State/province [202]
0
0
Chiba-shi, Chiba
Query!
Country [203]
0
0
Japan
Query!
State/province [203]
0
0
Chikushino-shi, Fukuoka
Query!
Country [204]
0
0
Japan
Query!
State/province [204]
0
0
Chuo-city, Yamanashi
Query!
Country [205]
0
0
Japan
Query!
State/province [205]
0
0
Fukuoka
Query!
Country [206]
0
0
Japan
Query!
State/province [206]
0
0
Fukuoka-shi, Fukuoka
Query!
Country [207]
0
0
Japan
Query!
State/province [207]
0
0
Hamamatsu-shi, Shizuoka
Query!
Country [208]
0
0
Japan
Query!
State/province [208]
0
0
Ibaraki
Query!
Country [209]
0
0
Japan
Query!
State/province [209]
0
0
Kishiwada, Osaka
Query!
Country [210]
0
0
Japan
Query!
State/province [210]
0
0
Koga-shi, Fukuoka
Query!
Country [211]
0
0
Japan
Query!
State/province [211]
0
0
Kumamoto-shi, Kumamoto
Query!
Country [212]
0
0
Japan
Query!
State/province [212]
0
0
Kure-shi, Hiroshima
Query!
Country [213]
0
0
Japan
Query!
State/province [213]
0
0
Kusegun, Kyoto
Query!
Country [214]
0
0
Japan
Query!
State/province [214]
0
0
Kyoto-shi, Kyoto
Query!
Country [215]
0
0
Japan
Query!
State/province [215]
0
0
Kyoto-shi,Kyoto
Query!
Country [216]
0
0
Japan
Query!
State/province [216]
0
0
Maebashi-shi, Gunma
Query!
Country [217]
0
0
Japan
Query!
State/province [217]
0
0
Matsubara-shi, Osaka
Query!
Country [218]
0
0
Japan
Query!
State/province [218]
0
0
Matsudo-shi
Query!
Country [219]
0
0
Japan
Query!
State/province [219]
0
0
Matsumoto-shi, Nagano
Query!
Country [220]
0
0
Japan
Query!
State/province [220]
0
0
Meguro-ku, Tokyo
Query!
Country [221]
0
0
Japan
Query!
State/province [221]
0
0
Minato-ku, Tokyo
Query!
Country [222]
0
0
Japan
Query!
State/province [222]
0
0
Miura-gun, Kanagawa
Query!
Country [223]
0
0
Japan
Query!
State/province [223]
0
0
Miyakonojo-shi, Miyazaki
Query!
Country [224]
0
0
Japan
Query!
State/province [224]
0
0
Morioka-shi, Iwate
Query!
Country [225]
0
0
Japan
Query!
State/province [225]
0
0
Nagoya-shi, Aichi
Query!
Country [226]
0
0
Japan
Query!
State/province [226]
0
0
Naha-shi, Okinawa
Query!
Country [227]
0
0
Japan
Query!
State/province [227]
0
0
Nara-shi, Nara
Query!
Country [228]
0
0
Japan
Query!
State/province [228]
0
0
Nishinomiya-shi, Hyogo
Query!
Country [229]
0
0
Japan
Query!
State/province [229]
0
0
Oita-shi, Oita
Query!
Country [230]
0
0
Japan
Query!
State/province [230]
0
0
Okayama
Query!
Country [231]
0
0
Japan
Query!
State/province [231]
0
0
Omihachiman-shi, Siga
Query!
Country [232]
0
0
Japan
Query!
State/province [232]
0
0
Osaka
Query!
Country [233]
0
0
Japan
Query!
State/province [233]
0
0
Osaka-city, Osaka
Query!
Country [234]
0
0
Japan
Query!
State/province [234]
0
0
Osaka-shi, Osaka
Query!
Country [235]
0
0
Japan
Query!
State/province [235]
0
0
Osaka-shi,Osaka
Query!
Country [236]
0
0
Japan
Query!
State/province [236]
0
0
Ota-shi, Gunma
Query!
Country [237]
0
0
Japan
Query!
State/province [237]
0
0
Sagamihara-shi, Kanagawa
Query!
Country [238]
0
0
Japan
Query!
State/province [238]
0
0
Saitama-shi, Saitama
Query!
Country [239]
0
0
Japan
Query!
State/province [239]
0
0
Sapporo-shi, Hokkaido
Query!
Country [240]
0
0
Japan
Query!
State/province [240]
0
0
Sendai-shi, Miyagi
Query!
Country [241]
0
0
Japan
Query!
State/province [241]
0
0
Suita-shi, Osaka
Query!
Country [242]
0
0
Japan
Query!
State/province [242]
0
0
Takamatsu-shi, Kagawa
Query!
Country [243]
0
0
Japan
Query!
State/province [243]
0
0
Tokyo
Query!
Country [244]
0
0
Japan
Query!
State/province [244]
0
0
Tondabayashi-shi, Osaka
Query!
Country [245]
0
0
Japan
Query!
State/province [245]
0
0
Tsukuba-shi, Ibaraki
Query!
Country [246]
0
0
Japan
Query!
State/province [246]
0
0
Wakayama
Query!
Country [247]
0
0
Japan
Query!
State/province [247]
0
0
Wako-shi, Saitama
Query!
Country [248]
0
0
Japan
Query!
State/province [248]
0
0
Yokohama-shi, Kanagawa
Query!
Country [249]
0
0
Japan
Query!
State/province [249]
0
0
Yonezawa-shi, Yamagata
Query!
Country [250]
0
0
Latvia
Query!
State/province [250]
0
0
Daugavpils
Query!
Country [251]
0
0
Latvia
Query!
State/province [251]
0
0
Jelgava
Query!
Country [252]
0
0
Latvia
Query!
State/province [252]
0
0
Riga
Query!
Country [253]
0
0
Lithuania
Query!
State/province [253]
0
0
Alytus
Query!
Country [254]
0
0
Lithuania
Query!
State/province [254]
0
0
Kaunas
Query!
Country [255]
0
0
Lithuania
Query!
State/province [255]
0
0
Klaipeda
Query!
Country [256]
0
0
Lithuania
Query!
State/province [256]
0
0
Panevezys
Query!
Country [257]
0
0
Lithuania
Query!
State/province [257]
0
0
Šiauliai
Query!
Country [258]
0
0
Lithuania
Query!
State/province [258]
0
0
Vilnius
Query!
Country [259]
0
0
Malaysia
Query!
State/province [259]
0
0
Kedah
Query!
Country [260]
0
0
Malaysia
Query!
State/province [260]
0
0
Kelantan
Query!
Country [261]
0
0
Malaysia
Query!
State/province [261]
0
0
Kuala Lumpur
Query!
Country [262]
0
0
Malaysia
Query!
State/province [262]
0
0
Perak
Query!
Country [263]
0
0
Malaysia
Query!
State/province [263]
0
0
Sarawak
Query!
Country [264]
0
0
Malaysia
Query!
State/province [264]
0
0
Selangor
Query!
Country [265]
0
0
Malaysia
Query!
State/province [265]
0
0
Ipoh, Perak
Query!
Country [266]
0
0
Malaysia
Query!
State/province [266]
0
0
Pulau Pinang
Query!
Country [267]
0
0
Malaysia
Query!
State/province [267]
0
0
Sabak Bernam
Query!
Country [268]
0
0
Malaysia
Query!
State/province [268]
0
0
Seremban
Query!
Country [269]
0
0
Mexico
Query!
State/province [269]
0
0
Jalisco
Query!
Country [270]
0
0
Mexico
Query!
State/province [270]
0
0
México, D.F.
Query!
Country [271]
0
0
Mexico
Query!
State/province [271]
0
0
Nuevo León
Query!
Country [272]
0
0
Mexico
Query!
State/province [272]
0
0
San Luis Potosí
Query!
Country [273]
0
0
Mexico
Query!
State/province [273]
0
0
Sinaloa
Query!
Country [274]
0
0
Mexico
Query!
State/province [274]
0
0
Aguascalientes
Query!
Country [275]
0
0
Mexico
Query!
State/province [275]
0
0
Querétaro
Query!
Country [276]
0
0
Mexico
Query!
State/province [276]
0
0
Veracruz
Query!
Country [277]
0
0
Netherlands
Query!
State/province [277]
0
0
Alkmaar
Query!
Country [278]
0
0
Netherlands
Query!
State/province [278]
0
0
Almelo
Query!
Country [279]
0
0
Netherlands
Query!
State/province [279]
0
0
Amsterdam
Query!
Country [280]
0
0
Netherlands
Query!
State/province [280]
0
0
Apeldoorn
Query!
Country [281]
0
0
Netherlands
Query!
State/province [281]
0
0
Breda
Query!
Country [282]
0
0
Netherlands
Query!
State/province [282]
0
0
Harderwijk
Query!
Country [283]
0
0
Netherlands
Query!
State/province [283]
0
0
Hilversum
Query!
Country [284]
0
0
Netherlands
Query!
State/province [284]
0
0
Roosendaal
Query!
Country [285]
0
0
Netherlands
Query!
State/province [285]
0
0
Rotterdam
Query!
Country [286]
0
0
Netherlands
Query!
State/province [286]
0
0
Sneek
Query!
Country [287]
0
0
Netherlands
Query!
State/province [287]
0
0
Zaandam
Query!
Country [288]
0
0
Poland
Query!
State/province [288]
0
0
Kuyavian-Pomeranian Voivodeship
Query!
Country [289]
0
0
Poland
Query!
State/province [289]
0
0
Lesser Poland Voivodeship
Query!
Country [290]
0
0
Poland
Query!
State/province [290]
0
0
Lower Silesian Voivodeship
Query!
Country [291]
0
0
Poland
Query!
State/province [291]
0
0
Lublin Voivodeship
Query!
Country [292]
0
0
Poland
Query!
State/province [292]
0
0
Lubusz Voivodeship
Query!
Country [293]
0
0
Poland
Query!
State/province [293]
0
0
Podlaskie Voivodeship
Query!
Country [294]
0
0
Poland
Query!
State/province [294]
0
0
Pomeranian Voivodeship
Query!
Country [295]
0
0
Poland
Query!
State/province [295]
0
0
Silesian Voivodeship
Query!
Country [296]
0
0
Poland
Query!
State/province [296]
0
0
Elblag
Query!
Country [297]
0
0
Poland
Query!
State/province [297]
0
0
Grodzisk Mazowiecki
Query!
Country [298]
0
0
Poland
Query!
State/province [298]
0
0
Krakow
Query!
Country [299]
0
0
Poland
Query!
State/province [299]
0
0
Lodz
Query!
Country [300]
0
0
Poland
Query!
State/province [300]
0
0
Poznan
Query!
Country [301]
0
0
Poland
Query!
State/province [301]
0
0
Pulawy
Query!
Country [302]
0
0
Poland
Query!
State/province [302]
0
0
Szczecin
Query!
Country [303]
0
0
Poland
Query!
State/province [303]
0
0
Tychy
Query!
Country [304]
0
0
Poland
Query!
State/province [304]
0
0
Warsaw
Query!
Country [305]
0
0
Poland
Query!
State/province [305]
0
0
Wegrów
Query!
Country [306]
0
0
Poland
Query!
State/province [306]
0
0
Wroclaw
Query!
Country [307]
0
0
Poland
Query!
State/province [307]
0
0
Zamosc
Query!
Country [308]
0
0
Poland
Query!
State/province [308]
0
0
Lódz Voivodeship
Query!
Country [309]
0
0
Portugal
Query!
State/province [309]
0
0
Lisbon District
Query!
Country [310]
0
0
Portugal
Query!
State/province [310]
0
0
Matosinhos
Query!
Country [311]
0
0
Portugal
Query!
State/province [311]
0
0
Almada
Query!
Country [312]
0
0
Portugal
Query!
State/province [312]
0
0
Aveiro
Query!
Country [313]
0
0
Portugal
Query!
State/province [313]
0
0
Braga
Query!
Country [314]
0
0
Portugal
Query!
State/province [314]
0
0
Coimbra
Query!
Country [315]
0
0
Portugal
Query!
State/province [315]
0
0
Guilhufe - Penafiel
Query!
Country [316]
0
0
Portugal
Query!
State/province [316]
0
0
Lisbon
Query!
Country [317]
0
0
Portugal
Query!
State/province [317]
0
0
Porto
Query!
Country [318]
0
0
Portugal
Query!
State/province [318]
0
0
Setúbal
Query!
Country [319]
0
0
Portugal
Query!
State/province [319]
0
0
Viana do Castelo
Query!
Country [320]
0
0
Portugal
Query!
State/province [320]
0
0
Vila Nova de Gaia
Query!
Country [321]
0
0
Romania
Query!
State/province [321]
0
0
Cluj
Query!
Country [322]
0
0
Romania
Query!
State/province [322]
0
0
Baia Mare
Query!
Country [323]
0
0
Romania
Query!
State/province [323]
0
0
Brasov
Query!
Country [324]
0
0
Romania
Query!
State/province [324]
0
0
Braila
Query!
Country [325]
0
0
Romania
Query!
State/province [325]
0
0
Bucharest
Query!
Country [326]
0
0
Romania
Query!
State/province [326]
0
0
Buzau
Query!
Country [327]
0
0
Romania
Query!
State/province [327]
0
0
Constan?a
Query!
Country [328]
0
0
Romania
Query!
State/province [328]
0
0
Craiova
Query!
Country [329]
0
0
Romania
Query!
State/province [329]
0
0
Galati
Query!
Country [330]
0
0
Romania
Query!
State/province [330]
0
0
Ia?i
Query!
Country [331]
0
0
Romania
Query!
State/province [331]
0
0
Oradea
Query!
Country [332]
0
0
Romania
Query!
State/province [332]
0
0
Pascani
Query!
Country [333]
0
0
Romania
Query!
State/province [333]
0
0
Pitesti
Query!
Country [334]
0
0
Romania
Query!
State/province [334]
0
0
Târgu Mures
Query!
Country [335]
0
0
Romania
Query!
State/province [335]
0
0
Timi?oara
Query!
Country [336]
0
0
Russia
Query!
State/province [336]
0
0
Barnaul
Query!
Country [337]
0
0
Russia
Query!
State/province [337]
0
0
Chelyabinsk
Query!
Country [338]
0
0
Russia
Query!
State/province [338]
0
0
Irkutsk
Query!
Country [339]
0
0
Russia
Query!
State/province [339]
0
0
Kazan'
Query!
Country [340]
0
0
Russia
Query!
State/province [340]
0
0
Moscow
Query!
Country [341]
0
0
Russia
Query!
State/province [341]
0
0
Novosibirsk
Query!
Country [342]
0
0
Russia
Query!
State/province [342]
0
0
Sochi
Query!
Country [343]
0
0
Russia
Query!
State/province [343]
0
0
Tomsk
Query!
Country [344]
0
0
Serbia
Query!
State/province [344]
0
0
Vojvodina
Query!
Country [345]
0
0
Serbia
Query!
State/province [345]
0
0
Belgrade
Query!
Country [346]
0
0
Serbia
Query!
State/province [346]
0
0
Kamenitz
Query!
Country [347]
0
0
Serbia
Query!
State/province [347]
0
0
Kragujevac
Query!
Country [348]
0
0
Serbia
Query!
State/province [348]
0
0
Niš
Query!
Country [349]
0
0
Serbia
Query!
State/province [349]
0
0
Novi Sad
Query!
Country [350]
0
0
Slovakia
Query!
State/province [350]
0
0
Bratislava
Query!
Country [351]
0
0
Slovakia
Query!
State/province [351]
0
0
Košice
Query!
Country [352]
0
0
Slovakia
Query!
State/province [352]
0
0
Levice
Query!
Country [353]
0
0
Slovakia
Query!
State/province [353]
0
0
Lucenec
Query!
Country [354]
0
0
Slovakia
Query!
State/province [354]
0
0
Lubochna
Query!
Country [355]
0
0
Slovakia
Query!
State/province [355]
0
0
Martin
Query!
Country [356]
0
0
Slovakia
Query!
State/province [356]
0
0
Nitra
Query!
Country [357]
0
0
Slovakia
Query!
State/province [357]
0
0
Nové Zámky
Query!
Country [358]
0
0
Slovakia
Query!
State/province [358]
0
0
Pieštany
Query!
Country [359]
0
0
Slovakia
Query!
State/province [359]
0
0
Prešov
Query!
Country [360]
0
0
South Africa
Query!
State/province [360]
0
0
Free State
Query!
Country [361]
0
0
South Africa
Query!
State/province [361]
0
0
Gauteng
Query!
Country [362]
0
0
South Africa
Query!
State/province [362]
0
0
KwaZulu-Natal
Query!
Country [363]
0
0
South Africa
Query!
State/province [363]
0
0
Western Cape
Query!
Country [364]
0
0
South Korea
Query!
State/province [364]
0
0
Busan
Query!
Country [365]
0
0
South Korea
Query!
State/province [365]
0
0
Daegu
Query!
Country [366]
0
0
South Korea
Query!
State/province [366]
0
0
Daejeon
Query!
Country [367]
0
0
South Korea
Query!
State/province [367]
0
0
Gangwon-do
Query!
Country [368]
0
0
South Korea
Query!
State/province [368]
0
0
Goyang
Query!
Country [369]
0
0
South Korea
Query!
State/province [369]
0
0
Gwangju
Query!
Country [370]
0
0
South Korea
Query!
State/province [370]
0
0
Gyeonggi-do
Query!
Country [371]
0
0
South Korea
Query!
State/province [371]
0
0
Incheon
Query!
Country [372]
0
0
South Korea
Query!
State/province [372]
0
0
Seoul
Query!
Country [373]
0
0
Spain
Query!
State/province [373]
0
0
Madrid
Query!
Country [374]
0
0
Spain
Query!
State/province [374]
0
0
Murcia
Query!
Country [375]
0
0
Spain
Query!
State/province [375]
0
0
Barakaldo
Query!
Country [376]
0
0
Spain
Query!
State/province [376]
0
0
Córdoba
Query!
Country [377]
0
0
Spain
Query!
State/province [377]
0
0
L' Hospitalet Del Llobregat
Query!
Country [378]
0
0
Spain
Query!
State/province [378]
0
0
Sanlúcar de Barrameda
Query!
Country [379]
0
0
Spain
Query!
State/province [379]
0
0
Seville
Query!
Country [380]
0
0
Spain
Query!
State/province [380]
0
0
Valencia
Query!
Country [381]
0
0
Spain
Query!
State/province [381]
0
0
Villamartín
Query!
Country [382]
0
0
Spain
Query!
State/province [382]
0
0
Zaragoza
Query!
Country [383]
0
0
Sweden
Query!
State/province [383]
0
0
Stockholm County
Query!
Country [384]
0
0
Sweden
Query!
State/province [384]
0
0
Gothenburg
Query!
Country [385]
0
0
Sweden
Query!
State/province [385]
0
0
Lund
Query!
Country [386]
0
0
Sweden
Query!
State/province [386]
0
0
Malmo
Query!
Country [387]
0
0
Sweden
Query!
State/province [387]
0
0
Stockholm
Query!
Country [388]
0
0
Sweden
Query!
State/province [388]
0
0
Uppsala
Query!
Country [389]
0
0
Taiwan
Query!
State/province [389]
0
0
Hsinchu
Query!
Country [390]
0
0
Taiwan
Query!
State/province [390]
0
0
Kaohsiung City
Query!
Country [391]
0
0
Taiwan
Query!
State/province [391]
0
0
Tainan City
Query!
Country [392]
0
0
Taiwan
Query!
State/province [392]
0
0
Taipei
Query!
Country [393]
0
0
Taiwan
Query!
State/province [393]
0
0
Taoyuan District
Query!
Country [394]
0
0
Taiwan
Query!
State/province [394]
0
0
Yilan
Query!
Country [395]
0
0
Thailand
Query!
State/province [395]
0
0
Bangkok
Query!
Country [396]
0
0
Thailand
Query!
State/province [396]
0
0
Changwat Pathum Thani
Query!
Country [397]
0
0
Thailand
Query!
State/province [397]
0
0
Changwat Songkhla
Query!
Country [398]
0
0
Thailand
Query!
State/province [398]
0
0
Mueang Chiang Mai
Query!
Country [399]
0
0
Thailand
Query!
State/province [399]
0
0
Patumwan
Query!
Country [400]
0
0
Thailand
Query!
State/province [400]
0
0
Rajathewee
Query!
Country [401]
0
0
Thailand
Query!
State/province [401]
0
0
Thung Phayathai Subdistrict
Query!
Country [402]
0
0
Thailand
Query!
State/province [402]
0
0
Chiang Mai
Query!
Country [403]
0
0
Thailand
Query!
State/province [403]
0
0
Khon Kaen
Query!
Country [404]
0
0
Thailand
Query!
State/province [404]
0
0
Nakhon Ratchasima
Query!
Country [405]
0
0
Thailand
Query!
State/province [405]
0
0
Pathum Thani
Query!
Country [406]
0
0
Thailand
Query!
State/province [406]
0
0
Songkhla
Query!
Country [407]
0
0
Thailand
Query!
State/province [407]
0
0
Ubon Ratchathani
Query!
Country [408]
0
0
Turkey (Türkiye)
Query!
State/province [408]
0
0
Bakirkoy
Query!
Country [409]
0
0
Turkey (Türkiye)
Query!
State/province [409]
0
0
Afyonkarahisar
Query!
Country [410]
0
0
Turkey (Türkiye)
Query!
State/province [410]
0
0
Ankara
Query!
Country [411]
0
0
Turkey (Türkiye)
Query!
State/province [411]
0
0
Antalya
Query!
Country [412]
0
0
Turkey (Türkiye)
Query!
State/province [412]
0
0
Aydin
Query!
Country [413]
0
0
Turkey (Türkiye)
Query!
State/province [413]
0
0
Edirne
Query!
Country [414]
0
0
Turkey (Türkiye)
Query!
State/province [414]
0
0
Eskisehir
Query!
Country [415]
0
0
Turkey (Türkiye)
Query!
State/province [415]
0
0
Istanbul
Query!
Country [416]
0
0
Turkey (Türkiye)
Query!
State/province [416]
0
0
Izmir
Query!
Country [417]
0
0
Turkey (Türkiye)
Query!
State/province [417]
0
0
Kahramanmaras
Query!
Country [418]
0
0
Turkey (Türkiye)
Query!
State/province [418]
0
0
Kayseri
Query!
Country [419]
0
0
Turkey (Türkiye)
Query!
State/province [419]
0
0
Kocaeli
Query!
Country [420]
0
0
Turkey (Türkiye)
Query!
State/province [420]
0
0
Mugla
Query!
Country [421]
0
0
Ukraine
Query!
State/province [421]
0
0
Chernivtsi
Query!
Country [422]
0
0
Ukraine
Query!
State/province [422]
0
0
Kharkiv
Query!
Country [423]
0
0
Ukraine
Query!
State/province [423]
0
0
Kyiv
Query!
Country [424]
0
0
United Kingdom
Query!
State/province [424]
0
0
Cheshire
Query!
Country [425]
0
0
United Kingdom
Query!
State/province [425]
0
0
Dorset
Query!
Country [426]
0
0
United Kingdom
Query!
State/province [426]
0
0
Lancashire
Query!
Country [427]
0
0
United Kingdom
Query!
State/province [427]
0
0
North Yorkshire
Query!
Country [428]
0
0
United Kingdom
Query!
State/province [428]
0
0
Northamptonshire
Query!
Country [429]
0
0
United Kingdom
Query!
State/province [429]
0
0
Surrey
Query!
Country [430]
0
0
United Kingdom
Query!
State/province [430]
0
0
West Sussex
Query!
Country [431]
0
0
United Kingdom
Query!
State/province [431]
0
0
Barnet
Query!
Country [432]
0
0
United Kingdom
Query!
State/province [432]
0
0
Bradford
Query!
Country [433]
0
0
United Kingdom
Query!
State/province [433]
0
0
Bradford-on-Avon
Query!
Country [434]
0
0
United Kingdom
Query!
State/province [434]
0
0
Bristol
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Country [435]
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United Kingdom
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Cambridge
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United Kingdom
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Exeter
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High Wycombe
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United Kingdom
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Leicester
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Lincoln
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Liverpool
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London
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Newcastle upon Tyne
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United Kingdom
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Oxford
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United Kingdom
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Preston
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United Kingdom
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Stevenage
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United Kingdom
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Stockton-on-Tees
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United Kingdom
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Torquay
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United Kingdom
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Wellingborough
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Funding & Sponsors
Primary sponsor type
Commercial sector/industry
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Name
Novo Nordisk A/S
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Ethics approval
Ethics application status
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Summary
Brief summary
This study is conducted to see if ziltivekimab reduces the risk of having cardiovascular events (for example heart attack and stroke) in people with cardiovascular disease, chronic kidney disease and inflammation. Participants will either get ziltivekimab (active medicine) or placebo (a dummy medicine which has no effect on the body). This is known as the study medicine. Which treatment participants get is decided by chance. Participants chance of getting ziltivekimab or placebo is the same. Ziltivekimab is not yet approved in any country or region in the world. It is a new medicine doctors cannot prescribe. Participants will get the study medicine in a pre filled syringe. Participants will need to use the pre filled syringe to inject the study medicine into a skinfold once-monthly. The study is expected to last for up to 4 years. Participants will have up to 20 clinic visits. Participants will have blood and urine samples taken at most of the clinic visits. Participants will have their heart examined using sound waves (echocardiography) and electrodes (electrocardiogram). Women cannot take part if pregnant, breast-feeding or planning to get pregnant during the study period.
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Trial website
https://clinicaltrials.gov/study/NCT05021835
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Trial related presentations / publications
Mohammadnia N, van Broekhoven A, Bax WA, Eikelboom JW, Mosterd A, Fiolet ATL, Tijssen JGP, Thompson PL, de Kleijn DPV, Tsimikas S, Cornel JH, Yeang C, El Messaoudi S. Interleukin-6 modifies Lipoprotein(a) and oxidized phospholipids associated cardiovascular disease risk in a secondary prevention cohort. Atherosclerosis. 2025 Jun;405:119211. doi: 10.1016/j.atherosclerosis.2025.119211. Epub 2025 Apr 26.
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Public notes
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Contacts
Principal investigator
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Clinical Transparency (dept. 2834)
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Address
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Novo Nordisk A/S
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Contact person for public queries
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Novo Nordisk
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Phone
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(+1) 866-867-7178
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[email protected]
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Contact person for scientific queries
Data sharing statement
Will individual participant data (IPD) for this trial be available (including data dictionaries)?
Yes
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What data in particular will be shared?
According to the Novo Nordisk disclosure commitment on novonordisk-trials.com
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When will data be available (start and end dates)?
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Available to whom?
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Available for what types of analyses?
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How or where can data be obtained?
IPD available at link: http://novonordisk-trials.com
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What supporting documents are/will be available?
No Supporting Document Provided
Results publications and other study-related documents
No documents have been uploaded by study researchers.
Results not provided in
https://clinicaltrials.gov/study/NCT05021835
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