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Trial details imported from ClinicalTrials.gov

For full trial details, please see the original record at https://clinicaltrials.gov/study/NCT04914897




Registration number
NCT04914897
Ethics application status
Date submitted
28/05/2021
Date registered
7/06/2021
Date last updated
2/10/2025

Titles & IDs
Public title
A Study of SAR444245 Combined With Other Anticancer Therapies for the Treatment of Participants With Lung Cancer or Mesothelioma (Pegathor Lung 202)
Scientific title
A Phase 2 Non-randomized, Open-label, Multi-cohort, Multi-center Study Assessing the Clinical Benefit of SAR444245 (THOR-707) Combined With Other Anticancer Therapies for the Treatment of Participants With Lung Cancer or Pleural Mesothelioma
Secondary ID [1] 0 0
U1111-1254-0107
Secondary ID [2] 0 0
ACT16849
Universal Trial Number (UTN)
Trial acronym
Linked study record

Health condition
Health condition(s) or problem(s) studied:
Pleural Mesothelioma 0 0
Non-small Cell Lung Cancer 0 0
Condition category
Condition code
Cancer 0 0 0 0
Lung - Mesothelioma
Cancer 0 0 0 0
Lung - Non small cell

Intervention/exposure
Study type
Interventional
Description of intervention(s) / exposure
Treatment: Drugs - THOR-707
Treatment: Drugs - Pembrolizumab

Experimental: Cohort A1: NSCLC, PD-L1 TPS >=50%:Pegenzileukin 24 µg/kg + Pembrolizumab as 1L Therapy - Participants with previously untreated Stage IV non-small cell lung cancer (NSCLC) and programmed cell death-ligand 1 (PD-L1) tumor proportion score (TPS) of \>=50% were included in this cohort. Participants received pegenzileukin 24 microgram per kilogram (µg/kg) along with pembrolizumab 200 milligram (mg) via intravenous (IV) infusion over 30 minutes every 3 weeks (q3w) on Day 1 of each cycle (each cycle is 21 days) (as first-line \[1L\] therapy), until disease progression (PD), unacceptable adverse event (AE) or other full permanent discontinuation criteria was met or completion of Cycle 35.

Experimental: Cohort A2: NSCLC, PD-L1 TPS 1%-49%:Pegenzileukin 24 µg/kg+Pembrolizumab as 1L Therapy - Participants with previously untreated Stage IV NSCLC and PD-L1 TPS of 1%-49% were included in this cohort. Participants received pegenzileukin 24 µg/kg along with pembrolizumab 200 mg via IV infusion over 30 minutes q3w on Day 1 of each cycle (each cycle is 21 days) (as 1L therapy), until PD, unacceptable AE or other full permanent discontinuation criteria was met or completion of Cycle 35.

Experimental: Cohort B1: NSCLC:Pegenzileukin 24 µg/kg+Pembrolizumab as 2/3L Therapy - Participants with NSCLC for whom standard of care (SOC) was not in their best interest or where no SOC was established were included in this cohort. Participants received pegenzileukin 24 µg/kg along with pembrolizumab 200 mg via IV infusion over 30 minutes q3w on Day 1 of each cycle (each cycle is 21 days) (as second-line or third-line \[2/3L\] therapy), until PD, unacceptable AE or other full permanent discontinuation criteria was met or completion of Cycle 35.

Experimental: Cohort C1: Mesothelioma: Pegenzileukin 24 µg /kg+Pembrolizumab as 2/3L Therapy - Participants with mesothelioma who had no SOC established and had experienced PD during or after at least one but no more than 2 prior regimens were included in this cohort. Participants received pegenzileukin 24 µg/kg along with pembrolizumab 200 mg via IV infusion over 30 minutes q3w on Day 1 of each cycle (each cycle is 21 days) (as 2/3L therapy), until PD, unacceptable AE or other full permanent discontinuation criteria was met or completion of Cycle 35.


Treatment: Drugs: THOR-707
Intravenous infusion: solution for infusion

Treatment: Drugs: Pembrolizumab
Intravenous infusion: solution for infusion

Intervention code [1] 0 0
Treatment: Drugs
Comparator / control treatment
Control group

Outcomes
Primary outcome [1] 0 0
Cohorts A1 and A2: Objective Response Rate (ORR)
Timepoint [1] 0 0
From first dose of study treatment administration (Day 1) up to approximately 21 months
Primary outcome [2] 0 0
Cohorts B1: Objective Response Rate
Timepoint [2] 0 0
From first dose of study treatment administration (Day 1) up to maximum exposure of study treatment; approximately 14 months
Primary outcome [3] 0 0
Cohorts C1: Objective Response Rate
Timepoint [3] 0 0
From first dose of study treatment administration (Day 1) up to approximately 21 months
Secondary outcome [1] 0 0
All Cohorts: Number of Participants With Treatment-Emergent Adverse Events (TEAEs) and Treatment-Emergent Serious Adverse Events (TESAEs)
Timepoint [1] 0 0
From first dose of study treatment (Day 1) up to 30 days after the last dose of study treatment; approximately 28 months (Cohorts A1 and A2), 15 months (Cohort B1), and 25 months (Cohort C1)
Secondary outcome [2] 0 0
All Cohorts: Number of Participants With Dose Limiting Toxicities (DLTs)
Timepoint [2] 0 0
From Day 1 to Day 21 of Cycle 1 (each cycle is 21 days)
Secondary outcome [3] 0 0
All Cohorts: Time to Response (TTR)
Timepoint [3] 0 0
From first dose of study treatment administration (Day 1) up to maximum exposure of study treatment; approximately 27 months (Cohorts A1 and A2), 14 months (Cohort B1), and 24 months (Cohort C1)
Secondary outcome [4] 0 0
All Cohorts: Duration of Response (DOR)
Timepoint [4] 0 0
From first dose of study treatment administration (Day 1) up to maximum exposure of study treatment; approximately 27 months (Cohorts A1 and A2), 14 months (Cohort B1), and 24 months (Cohort C1)
Secondary outcome [5] 0 0
All Cohorts: Clinical Benefit Rate (CBR)
Timepoint [5] 0 0
From first dose of study treatment administration (Day 1) up to maximum exposure of study treatment; approximately 27 months (Cohorts A1 and A2), 14 months (Cohort B1), and 24 months (Cohort C1)
Secondary outcome [6] 0 0
All Cohorts: Progression Free Survival (PFS)
Timepoint [6] 0 0
From first dose of study treatment administration (Day 1) up to maximum exposure of study treatment; approximately 27 months (Cohorts A1 and A2), 14 months (Cohort B1), and 24 months (Cohort C1)
Secondary outcome [7] 0 0
All Cohorts: Plasma Concentrations of Pegenzileukin
Timepoint [7] 0 0
Days 2 and 3 of Cycle 1 (each cycle is 21 days)
Secondary outcome [8] 0 0
All Cohorts: Concentration at End of Infusion (Ceoi) of Pegenzileukin
Timepoint [8] 0 0
Cycles 1, 2, 4, 7, 10, and 15 (each cycle is 21 days)
Secondary outcome [9] 0 0
All Cohorts: Number of Participants With Anti-Drug Antibodies (ADAs) Against Pegenzileukin
Timepoint [9] 0 0
From first dose of study treatment (Day 1) up to 30 days after the last dose of study treatment; approximately 28 months (Cohorts A1 and A2), 15 months (Cohort B1), and 25 months (Cohort C1)

Eligibility
Key inclusion criteria
* Participant must have been =18 years of age (or country's legal age of majority if >18 years), at the time of signing the informed consent.
* Histologically or cytologically confirmed diagnosis of Stage IV NSCLC (cohorts A1, A2, and B1), or unresectable malignant pleural mesothelioma (cohort C1).
* Cohort A1: PD-L1 expression TPS = 50%
* Cohort A2: PD-L1 expression TPS 1 - 49%
* Prior anticancer therapy
* Cohorts A1 and A2: No prior systemic therapy for advanced/metastatic NSCLC. Participants who received adjuvant or neoadjuvant therapy are eligible if the adjuvant/neoadjuvant therapy was completed at least 6 months prior to the development of metastatic disease.
* Cohort B1: One prior anti-PD1/PD-L1 regimen (may include chemotherapy) plus one additional chemotherapy regimen
* Cohort C1: One or two prior systemic treatments that include pemetrexed-based regimen in combination with platinum agent.
* All cohorts must have had a measurable disease
* Mandatory baseline biopsy for the first 20 participants to enroll in cohorts A1, A2
* Cohort B1: Based on the Investigator's judgment, either docetaxel or pemetrexed is not the best treatment option for the participant.
* Females were eligible to participate if they were not pregnant or breastfeeding, not a woman of childbearing potential (WOCBP) or are a WOCBP that agrees:

* to use approved contraception method and submit to regular pregnancy testing prior to treatment and for 150 days after discontinuing study treatment
* to refrain from donating or cryopreserving eggs for 150 days after discontinuing study treatment.
* Males were eligible to participate if they agree to refrain from donating or cryopreserving sperm, and either abstain from heterosexual intercourse OR use approved contraception during study treatment and for at least 210 days after discontinuing study treatment.
* Capable of giving signed informed consent.
Minimum age
18 Years
Maximum age
No limit
Sex
Both males and females
Can healthy volunteers participate?
No
Key exclusion criteria
Participants were excluded from the study if any of the following criteria applied:

* Eastern Cooperative Oncology Group (ECOG) performance status of = 2.
* Poor bone marrow reserve
* Poor organ function
* Participants with baseline SpO2 = 92%.
* Active brain metastases or leptomeningeal disease.
* History of allogenic tissue/solid organ transplant
* Last administration of prior antitumor therapy or any investigational treatment within 28 days or less than 5 times the half-life, whichever is shorter; major surgery or local intervention within 28 days.
* Has received prior IL-2-based anticancer treatment.
* Comorbidity requiring corticosteroid therapy
* Antibiotic use (excluding topical antibiotics) =14 days prior to first dose of IMP
* Severe or unstable cardiac condition within 6 months prior to starting study treatment
* Active, known, or suspected autoimmune disease that has required systemic treatment in the past 2 years
* Known second malignancy either progressing or requiring active treatment within the last 3 years
* Cohorts A1, A2, and C1: Prior treatment with an agent (approved or investigational) that blocks the PD1/PD-L1 pathway (participants who joined a study with an anti-PD1/PD-L1 but have written confirmation they were on control arm are allowed).
* Receipt of a live-virus vaccination within 28 days of planned treatment start. Seasonal flu vaccines that do not contain live virus are permitted.

The above information is not intended to contain all considerations relevant to the potential participation in a clinical trial.

Study design
Purpose of the study
Treatment
Allocation to intervention
Non-randomised trial
Procedure for enrolling a subject and allocating the treatment (allocation concealment procedures)
Methods used to generate the sequence in which subjects will be randomised (sequence generation)
Masking / blinding
Open (masking not used)
Who is / are masked / blinded?



Intervention assignment
Parallel
Other design features
Phase
Phase 2
Type of endpoint/s
Statistical methods / analysis

Recruitment
Recruitment status
Stopped early
Data analysis
Reason for early stopping/withdrawal
Other reasons
Date of first participant enrolment
Anticipated
Actual
Date of last participant enrolment
Anticipated
Actual
Date of last data collection
Anticipated
Actual
Sample size
Target
Accrual to date
Final
Recruitment in Australia
Recruitment state(s)
VIC
Recruitment hospital [1] 0 0
Investigational Site Number : 0360002 - Richmond
Recruitment postcode(s) [1] 0 0
3121 - Richmond
Recruitment outside Australia
Country [1] 0 0
United States of America
State/province [1] 0 0
Pennsylvania
Country [2] 0 0
Argentina
State/province [2] 0 0
Buenos Aires
Country [3] 0 0
Chile
State/province [3] 0 0
Reg Metropolitana de Santiago
Country [4] 0 0
Chile
State/province [4] 0 0
Temuco
Country [5] 0 0
France
State/province [5] 0 0
Bordeaux
Country [6] 0 0
France
State/province [6] 0 0
Paris
Country [7] 0 0
France
State/province [7] 0 0
Saint-Herblain
Country [8] 0 0
France
State/province [8] 0 0
Toulouse
Country [9] 0 0
Italy
State/province [9] 0 0
Friuli Venezia Giulia
Country [10] 0 0
Italy
State/province [10] 0 0
Milano
Country [11] 0 0
Italy
State/province [11] 0 0
Torino
Country [12] 0 0
Italy
State/province [12] 0 0
Bologna
Country [13] 0 0
Italy
State/province [13] 0 0
Milan
Country [14] 0 0
Italy
State/province [14] 0 0
Padua
Country [15] 0 0
Japan
State/province [15] 0 0
Hokkaido
Country [16] 0 0
Poland
State/province [16] 0 0
Greater Poland Voivodeship
Country [17] 0 0
Poland
State/province [17] 0 0
Masovian Voivodeship
Country [18] 0 0
Poland
State/province [18] 0 0
Pomeranian Voivodeship
Country [19] 0 0
Poland
State/province [19] 0 0
Warmian-Masurian Voivodeship
Country [20] 0 0
South Korea
State/province [20] 0 0
Seoul-teukbyeolsi
Country [21] 0 0
Spain
State/province [21] 0 0
Barcelona [Barcelona]
Country [22] 0 0
Spain
State/province [22] 0 0
Girona [Gerona]
Country [23] 0 0
Spain
State/province [23] 0 0
Madrid, Comunidad de
Country [24] 0 0
Spain
State/province [24] 0 0
Madrid
Country [25] 0 0
Taiwan
State/province [25] 0 0
Taichung
Country [26] 0 0
Taiwan
State/province [26] 0 0
Tainan City
Country [27] 0 0
Taiwan
State/province [27] 0 0
Taipei

Funding & Sponsors
Primary sponsor type
Commercial sector/industry
Name
Sanofi
Address
Country
Other collaborator category [1] 0 0
Commercial sector/industry
Name [1] 0 0
Merck Sharp & Dohme LLC
Address [1] 0 0
Country [1] 0 0

Ethics approval
Ethics application status

Summary
Brief summary
Trial website
Trial related presentations / publications
Public notes

Contacts
Principal investigator
Name 0 0
Address 0 0
Country 0 0
Phone 0 0
Fax 0 0
Email 0 0
Contact person for public queries
Name 0 0
Address 0 0
Country 0 0
Phone 0 0
Fax 0 0
Email 0 0
Contact person for scientific queries

Data sharing statement
Will individual participant data (IPD) for this trial be available (including data dictionaries)?
Yes
What data in particular will be shared?
Qualified researchers may request access to patient level data and related study documents including the clinical study report, study protocol with any amendments, blank case report form, statistical analysis plan, and dataset specifications. Patient level data will be anonymized and study documents will be redacted to protect the privacy of trial participants. Further details on Sanofi's data sharing criteria, eligible studies, and process for requesting access can be found at: https://vivli.org
When will data be available (start and end dates)?
Available to whom?
Available for what types of analyses?
How or where can data be obtained?


What supporting documents are/will be available?

Results publications and other study-related documents

No documents have been uploaded by study researchers.