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Trial registered on ANZCTR

Registration number
Ethics application status
Date submitted
Date registered
Date last updated
Type of registration
Retrospectively registered

Titles & IDs
Public title
The acute effects of moderate intensity aerobic, resistance and combination exercise on components of the metabolic syndrome in overweight and obese individuals.
Scientific title
Overweight and obese individuals and the acute effects of moderate intensity aerobic, resistance and combination exercise on components of the metabolic syndrome.
Universal Trial Number (UTN)
Trial acronym
Linked study record

Health condition
Health condition(s) or problem(s) studied:
Metabolic syndrome risk factors in overweight and obese individuals 3800 0
Condition category
Condition code
Public Health 3981 3981 0 0
Health promotion/education

Study type
Description of intervention(s) / exposure
The study was a randomized cross-over design examining the postprandial effects of different types of exercise in the evening prior to a breakfast meal. Subjects were randomized on four occasions, each one-week apart, to each intervention, either no exercise (control), 30 minutes of aerobic exercise on a treadmill, 30 minutes of resistance exercise (leg press, leg curl, leg extension, bench press, rear deltoid row) or a combination of 15 minutes of aerobic exercise and 15 minutes of resistance exercise. A postprandial response was measured following the breakfast meal.
Intervention code [1] 3521 0
Treatment: Other
Intervention code [2] 237050 0
Comparator / control treatment
No exercise
Control group

Primary outcome [1] 4883 0
Blood lipids and lipoprotein status as well as glucose and insulin sensitivity the day after the exercise intervention.
Timepoint [1] 4883 0
Blood samples taken at baseline, then 30 mins, 1 hr, 2.5 hrs, 4 hrs, 5 hrs, 6 hrs and 8 hrs after a standard meal.
Primary outcome [2] 5814 0
Endothelial function measured via Sphygmocor pulse wave analysis (PWA).
Timepoint [2] 5814 0
Baseline, 1 hr, 2 hrs, 3 hrs, 4 hrs, 6 hrs and 8 hrs
Secondary outcome [1] 241816 0
Resting energy expenditure and fat oxidation measured via indirect open-circuit calorimetry.
Timepoint [1] 241816 0
Baseline, 30 mins, 1.5 hrs, 2.5 hrs, 3.5 hrs and 5.5 hrs

Key inclusion criteria
Overweight or moderately obese postmenopausal women and men who were sedentary.
Minimum age
50 Years
Maximum age
67 Years
Both males and females
Can healthy volunteers participate?
Key exclusion criteria
Diabetes mellitus, pre-existing heart conditions, pregnant or lactating, smokers, gastrointestinal tract surgery, any other major illness.

Study design
Purpose of the study
Allocation to intervention
Randomised controlled trial
Procedure for enrolling a subject and allocating the treatment (allocation concealment procedures)
Subjects were allocated to the randomly generated sequence of control, aerobic, resistance or combination exercise in the order they were recruited.
Methods used to generate the sequence in which subjects will be randomised (sequence generation)
Computer program generated randomization plan.
Masking / blinding
Open (masking not used)
Who is / are masked / blinded?

Intervention assignment
Other design features
Not Applicable
Type of endpoint(s)
Statistical methods / analysis

Recruitment status
Date of first participant enrolment
Date of last participant enrolment
Date of last data collection
Sample size
Accrual to date
Recruitment in Australia
Recruitment state(s)

Funding & Sponsors
Funding source category [1] 4843 0
Self funded/Unfunded
Name [1] 4843 0
Address [1] 4843 0
Country [1] 4843 0
Primary sponsor type
Curtin University of Technology
Curtin University
GPO Box U1987
Perth WA 6845
Secondary sponsor category [1] 4380 0
Name [1] 4380 0
Address [1] 4380 0
Country [1] 4380 0

Ethics approval
Ethics application status
Ethics committee name [1] 6899 0
Curtin University Ethics Commitee
Ethics committee address [1] 6899 0
GPO Box U1987 Perth WA 6845
Ethics committee country [1] 6899 0
Date submitted for ethics approval [1] 6899 0
Approval date [1] 6899 0
Ethics approval number [1] 6899 0
HR 75/2004

Brief summary
The metabolic syndrome (MS) is a term used to describe the clustering of metabolic risk factors, such as abdominal obesity, insulin resistance, dyslipidaemia and elevated blood pressure. It is estimated that 20-25% of the world’s adult population have the metabolic syndrome. Having the risk factors associated with the MS leads to an increased risk of developing cardiovascular disease (CVD) and such individuals are also five times more likely to develop Type 2 diabetes. The root causes of the MS are described as being a combination of being overweight or obese, physical inactivity and genetic factors. Cardiovascular disease is a major cause of death in Australia and most industrialized countries. Atherosclerosis is the main cause of CVD. The initiation of atherosclerosis is the accumulation of lipid deposited by circulating lipoproteins within the arterial wall. Postprandial lipaemia (after meal blood lipid appearance) induced by eating a fatty meal increases circulating levels of lipid. Increased postprandial lipid levels have the potential to deposit into the arterial wall and develop into an atherosclerotic lesion. However, exercise decreases postprandial lipaemia as an acute (short-term) effect after a single bout. The aim of this study was to investigate whether a single 30-minute bout of resistance, aerobic or combined exercise at moderate intensity would decrease postprandial lipaemia, glucose and insulin levels of a high fat meal consumed 14 hours after the exercise bout, as well as increase resting energy expenditure and increase fat oxidation in overweight and obese individuals compared to no exercise. We also compared the effects of the different exercise modalities.
Trial website
Trial related presentations / publications
Public notes

Principal investigator
Name 29014 0
Address 29014 0
Country 29014 0
Phone 29014 0
Fax 29014 0
Email 29014 0
Contact person for public queries
Name 12171 0
Assoc Prof Sebely Pal
Address 12171 0
Curtin University
GPO Box U1987
Perth WA 6845
Country 12171 0
Phone 12171 0
+61 8 9266 4755
Fax 12171 0
Email 12171 0
Contact person for scientific queries
Name 3099 0
Assoc Prof Sebely Pal
Address 3099 0
Curtin University
GPO Box U1987
Perth WA 6845
Country 3099 0
Phone 3099 0
+61 8 9266 4755
Fax 3099 0
Email 3099 0

No information has been provided regarding IPD availability
Summary results
Have study results been published in a peer-reviewed journal?
Other publications
Have study results been made publicly available in another format?
Results – basic reporting
Results – plain English summary