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Trial registered on ANZCTR

Registration number
Ethics application status
Date submitted
Date registered
Date last updated
Type of registration
Retrospectively registered

Titles & IDs
Public title
Developing a research base for Intravenous Peripheral catheter resites: the DRIP Trial
Scientific title
Randomised Controlled Trial of routine versus clinically indicated resite of peripheral intravenous devices in hospitalised patients to prevent phlebitis
Secondary ID [1] 283448 0
Nil known
Universal Trial Number (UTN)
Trial acronym
Linked study record

Health condition
Health condition(s) or problem(s) studied:
phlebitis 3511 0
Condition category
Condition code
Infection 3665 3665 0 0
Studies of infection and infectious agents

Study type
Description of intervention(s) / exposure
Patients in this study are generic medical/surgical/oncology hospitalised patients who require a peripheral intravenous device. Patients will have their peripheral intravenous devices (IVs) removed after 72-96 hours of use a new IV resited in another vein. This will continue for the course of IV therapy, that is as long as IV therapy is required.
Intervention code [1] 3230 0
Comparator / control treatment
Patients will have their intravenous devices (IVs) left in situ for as long as treatment continues unless they have phlebitis or IV malfunction. The overall duration is for the course of treatment with an IV e.g. for a course of antibiotics or rehydration.
Control group

Primary outcome [1] 4569 0
Phlebitis during catheterisation or up to 48 hours after catheter removal. Phlebitis defined as 2 or more of: pain, tenderness, erythema, swelling, purulence, and/or palpable venous cord.
Timepoint [1] 4569 0
Daily while cannulae is in situ and for 48 hours post removal
Secondary outcome [1] 7722 0
Catheter related bloodstream infection: Bacteremia/fungemia with more than 1 positive blood culture obtained from a peripheral vein, clinical manifestations of infections (i.e.fever, chills, and/or hypotension), and no apparent source for the BSI except the catheter. One of the following should be present: a positive semiquantitative (>15 colony forming units(CFU) /catheter segment) or quantitative (>103 CFU/catheter segment catheter)
culture whereby the same organism (species and antibiogram) is isolated from the catheter segment and peripheral blood; simultaneous quantitative blood cultures with a >5:1 ratio IV versus peripheral; differential period of IV culture versus peripheral blood culture positivity of >2 hours.
Timepoint [1] 7722 0
Daily while cannulae is in situ or for 48 hours post removal

Key inclusion criteria
Scheduled or expected to have a peripheral IV in situ for 4 days or more, written informed consent
Minimum age
18 Years
Maximum age
No limit
Both males and females
Can healthy volunteers participate?
Key exclusion criteria
current bacteraemia, planned removal of IV within 24 hours, IV already in situ for more than 48hrs

Study design
Purpose of the study
Allocation to intervention
Randomised controlled trial
Procedure for enrolling a subject and allocating the treatment (allocation concealment procedures)
computer generated allocation provided by electronic data collection device. Allocation is concealed until the patient is randomised
Methods used to generate the sequence in which subjects will be randomised (sequence generation)
computer generated
Masking / blinding
Open (masking not used)
Who is / are masked / blinded?

Intervention assignment
Other design features
Not Applicable
Type of endpoint(s)
Statistical methods / analysis

Recruitment status
Date of first participant enrolment
Date of last participant enrolment
Date of last data collection
Sample size
Accrual to date
Recruitment in Australia
Recruitment state(s)
Recruitment hospital [1] 1614 0
Royal Brisbane & Womens Hospital - Herston
Recruitment postcode(s) [1] 7496 0
4029 - Royal Brisbane Hospital

Funding & Sponsors
Funding source category [1] 3687 0
Government body
Name [1] 3687 0
National Health and Medical Research Council (NHMRC)
Address [1] 3687 0
GPO Box 1421 Canberra, ACT 2601
Country [1] 3687 0
Funding source category [2] 3688 0
Name [2] 3688 0
Royal Brisbane and Women's Hospital
Address [2] 3688 0
1 Butterfield St, Herston QLD 4029
Country [2] 3688 0
Funding source category [3] 3689 0
Name [3] 3689 0
Princess Alexandra Hospital
Address [3] 3689 0
199 Ipswich Rd, Woolloongabba QLD 4102
Country [3] 3689 0
Funding source category [4] 3690 0
Name [4] 3690 0
Gold Coast Hospital
Address [4] 3690 0
108 Nerang St Southport QLD 4215
Country [4] 3690 0
Funding source category [5] 3691 0
Name [5] 3691 0
Griffith University
Address [5] 3691 0
Nathan Campus, 170 Kessels rd, Nathan QLD 4111
Country [5] 3691 0
Primary sponsor type
Griffith University
Research Centre for Clinical and Community Practice Innovation, Nathan Campus 170 Kessels Road Nathan QLD 4111
Secondary sponsor category [1] 3308 0
Name [1] 3308 0
Address [1] 3308 0
Country [1] 3308 0

Ethics approval
Ethics application status
Ethics committee name [1] 5737 0
Royal Brisbane and Women's Hospital
Ethics committee address [1] 5737 0
1 Butterfield St herston QLD 4029
Ethics committee country [1] 5737 0
Date submitted for ethics approval [1] 5737 0
Approval date [1] 5737 0
Ethics approval number [1] 5737 0

Brief summary
In Australia each year ten million IV drips are inserted in patients’ arms or in the backs of their hands to give fluid and medications.
Many drips are routinely replaced every few days in the hope that this reduces infection, however preliminary research suggests it would be better and more cost effective to leave them alone. That would save patients the pain of another needle as well as interruption to treatment. It would save doctors and nurses time, and reduce waste from plastic disposables. The research will provide the evidence to know one way or the other whether IV drips should be routinely changed or left alone.
Trial website
Trial related presentations / publications
Public notes

Principal investigator
Name 28811 0
Prof Claire Rickard
Address 28811 0
Griffith University 170 Kessels Road, Nathan QLD 4111
Country 28811 0
Phone 28811 0
+61 7 3735 6460
Fax 28811 0
Email 28811 0
Contact person for public queries
Name 11968 0
Prof Prof Claire Rickard
Address 11968 0
Griffith University
170 Kessels Road, Nathan QLD 4111
Country 11968 0
Phone 11968 0
07 3735 6460
Fax 11968 0
Email 11968 0
Contact person for scientific queries
Name 2896 0
Prof Prof Claire Rickard
Address 2896 0
Griffith University
Nathan Campus
170 Kessels Road
Nathan QLD 4111
Country 2896 0
Phone 2896 0
07 3735 6460
Fax 2896 0
Email 2896 0

No information has been provided regarding IPD availability
Summary results
Have study results been published in a peer-reviewed journal?
Other publications
Have study results been made publicly available in another format?
Results – basic reporting
Results – plain English summary