Technical difficulties have been reported by some users of the search function and is being investigated by technical staff. Thank you for your patience and apologies for any inconvenience caused.

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been endorsed by the ANZCTR. Before participating in a study, talk to your health care provider and refer to this information for consumers
Trial registered on ANZCTR

Registration number
Ethics application status
Date submitted
Date registered
Date last updated
Type of registration
Prospectively registered

Titles & IDs
Public title
Finding the Genes for Gout: the effect of fructose
Scientific title
The influence of genetic variants on fructose-induced hyperuricaemia
Secondary ID [1] 253146 0
Universal Trial Number (UTN)
Trial acronym
Linked study record

Health condition
Health condition(s) or problem(s) studied:
Hyperuricaemia 258697 0
Gout 258707 0
Condition category
Condition code
Metabolic and Endocrine 258849 258849 0 0
Other metabolic disorders

Study type
Patient registry
Target follow-up duration
Target follow-up type
Description of intervention(s) / exposure
A sugar solution of 300kcal/300ml will be administered to all participants. This solution will contain 80% fructose and 20% glucose (64g fructose and 16g glucose). Participants will then be observed for three hours.
Intervention code [1] 257652 0
Not applicable
Comparator / control treatment
Control group

Primary outcome [1] 259702 0
Change in serum urate concentration following a fructose challenge (blood test)
Timepoint [1] 259702 0
30 minutes, 60 minutes, 120 minutes, and 180 minutes after ingestion
Secondary outcome [1] 266421 0
Change in fractional excretion of urate to 3 hours following a fructose challenge (blood and urine test)
Timepoint [1] 266421 0
30 minutes, 60 minutes, 120 minutes, and 180 minutes after ingestion

Key inclusion criteria
Able to provide written informed consent
Minimum age
18 Years
Maximum age
85 Years
Both males and females
Can healthy volunteers participate?
Key exclusion criteria
a. History of gout
b. History of diabetes mellitus
c. History of fructose intolerance
d. Diuretic use
e. Fasting capillary glucose >6mmol/L

Study design
Natural history
Convenience sample
Statistical methods / analysis

Recruitment status
Date of first participant enrolment
Date of last participant enrolment
Date of last data collection
Sample size
Accrual to date
Recruitment outside Australia
Country [1] 3063 0
New Zealand
State/province [1] 3063 0

Funding & Sponsors
Funding source category [1] 258119 0
Government body
Name [1] 258119 0
Health Research Council of New Zealand
Country [1] 258119 0
New Zealand
Primary sponsor type
Government body
Health Research Council of New Zealand
PO Box 5541, Wellesley Street, Auckland, 1141, New Zealand
New Zealand
Secondary sponsor category [1] 257297 0
Name [1] 257297 0
Address [1] 257297 0
Country [1] 257297 0

Ethics approval
Ethics application status
Ethics committee name [1] 260103 0
Multiregion Ethics Committee
Ethics committee address [1] 260103 0
PO Box 5013
Ethics committee country [1] 260103 0
New Zealand
Date submitted for ethics approval [1] 260103 0
Approval date [1] 260103 0
Ethics approval number [1] 260103 0

Brief summary
We have previously identified genetic variation in a urate transporter gene SLC2A9 as a key risk factor for development of gout in those of Maori, Pacific and Caucasian ancestry. This transporter is also a fructose transporter and in vitro assays have shown that fructose promotes transport of urate via SLC2A9. These observations are of clinical relevance, as fructose ingestion has been strongly associated with development of hyperuricaemia and gout.

We wish to extend our initial observations by examining the influence of SLC2A9 genetic variation on fructose-induced hyperuricaemia. The primary hypothesis is that individuals possessing at least one protective allele at rs11942223 have a lower hyperuricaemic response to a fructose challenge.

This study involves a fructose challenge test for 75 healthy volunteer control participants. The fructose challenge test takes approximately 3 hours and involves ingestion of a fructose/glucose drink and serial measurements of blood urate, creatinine and glucose. Blood will also be obtained for genotyping of SLC2A9 variants and other variants associated with hyperuricaemia
Trial website
Trial related presentations / publications
Public notes

Principal investigator
Name 31944 0
Prof Nicola Dalbeth
Address 31944 0
Room 502-201D
Bone and Joint Research Group
Department of Medicine
Faculty of Medical and Health Sciences
University of Auckland
85 Park Rd, Grafton, Auckland 1023
Country 31944 0
New Zealand
Phone 31944 0
+64 (0) 9 3737999 x82568
Fax 31944 0
Email 31944 0
Contact person for public queries
Name 15191 0
Nicola Dalbeth
Address 15191 0
Bone and Joint Research Group
Department of Medicine
Faculty of Medical and Health Sciences
University of Auckland
Park Rd , Grafton, Auckland 1023
Country 15191 0
New Zealand
Phone 15191 0
+64 (0) 9 3737999 x82568
Fax 15191 0
Email 15191 0
Contact person for scientific queries
Name 6119 0
Nicola Dalbeth
Address 6119 0
Bone and Joint Research Group
Department of Medicine
Faculty of Medical and Health Sciences
University of Auckland
Park Rd , Grafton, Auckland 1023
Country 6119 0
New Zealand
Phone 6119 0
+64 (0) 9 3737999 x82568
Fax 6119 0
Email 6119 0

No information has been provided regarding IPD availability

What supporting documents are/will be available?

No Supporting Document Provided

Results publications and other study-related documents

Documents added manually
No documents have been uploaded by study researchers.

Documents added automatically
SourceTitleYear of PublicationDOI
Dimensions AIInfluence of the ABCG2 gout risk 141 K allele on urate metabolism during a fructose challenge2014
Dimensions AIBody mass index modulates the relationship of sugar-sweetened beverage intake with serum urate concentrations and gout2015
N.B. These documents automatically identified may not have been verified by the study sponsor.