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Trial details imported from

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Registration number
Ethics application status
Date submitted
Date registered
Date last updated

Titles & IDs
Public title
A Comparison of Two Exercise Programs on Knee Motor Control
Scientific title
The Effect of Specific Versus Generalised Quadriceps Exercise on Neural Control of the Vasti
Secondary ID [1] 0 0
Universal Trial Number (UTN)
Trial acronym
Linked study record

Health condition
Health condition(s) or problem(s) studied:
Knee Pain 0 0
Patellofemoral Pain 0 0
Condition category
Condition code

Study type
Description of intervention(s) / exposure
Behaviour - Motor control retraining program
Behaviour - Quadriceps strengthening program

Experimental: 1 - Motor control retraining program

Behaviour: Motor control retraining program
Specific retraining of VMO activation in a low-load situation,and progressed to integrate more functional positions. Use of dual channel biofeedback was incorporated

Behaviour: Quadriceps strengthening program
4 exercises focused on quadriceps strengthening commencing at a resistance of 60% 1 repetition maximum. Each exercise was performed for 3 sets of 10 repetitions

Intervention code [1] 0 0
Comparator / control treatment
Control group

Primary outcome [1] 0 0
latency between the onset of VMO electromyographic activity relative to that of VL during stair ascent and stair descent measured using surface electrodes
Timepoint [1] 0 0
6 weeks with 8 week followup
Secondary outcome [1] 0 0
Concentric and eccentric quadriceps muscle strength as assessed by isokinetic dynamometry
Timepoint [1] 0 0
6 weeks with 8 week followup

Key inclusion criteria
- aged between 16-40 years, with the upper age limit to reduce the likelihood of
osteoarthritic changes in the patellofemoral joint

- a self-reported history of anterior or retropatellar knee pain with insidious onset of
symptoms and with at least one episode of pain in the past 12 months where pain was
aggravated by at least two of the following: prolonged sitting, stairs, squat,
running, kneeling and hopping/jumping

- currently asymptomatic for at least 8 weeks prior to assessment

- delay in the onset of VMO EMG relative to that of VL of greater than 10 ms during
either the ascent or descent of a stair stepping task
Minimum age
16 Years
Maximum age
40 Years
Both males and females
Can healthy volunteers participate?
Key exclusion criteria
- current knee pain

- history of knee surgery or other knee injury in previous 12 months

- physiotherapy treatment for knee pain in the past 12 months

- history of patellar dislocation/subluxation

- clinical evidence of meniscal lesion, ligamentous instability, traction apophysitis
around the patellofemoral complex, patellar tendon pathology, chondral damage,
osteoarthritis and spinal referred pain

- current lower limb pathology affecting their ability to satisfactorily complete the
testing or exercise protocol

- current use of non-steroidal anti-inflammatory or corticosteroid drugs

- inability to communicate and comprehend written or verbal instructions in English

Study design
Purpose of the study
Allocation to intervention
Randomised controlled trial
Procedure for enrolling a subject and allocating the treatment (allocation concealment procedures)
Methods used to generate the sequence in which subjects will be randomised (sequence generation)
Masking / blinding
Blinded (masking used)
Who is / are masked / blinded?

The people assessing the outcomes
Intervention assignment
Other design features
Phase 2
Type of endpoint(s)
Statistical methods / analysis

Recruitment status
Data analysis
Reason for early stopping/withdrawal
Other reasons
Date of first participant enrolment
Date of last participant enrolment
Date of last data collection
Sample size
Accrual to date
Recruitment in Australia
Recruitment state(s)
Recruitment hospital [1] 0 0
University of Melbourne - Melbourne
Recruitment postcode(s) [1] 0 0
3010 - Melbourne

Funding & Sponsors
Primary sponsor type
University of Melbourne
Other collaborator category [1] 0 0
Name [1] 0 0
National Health and Medical Research Council, Australia
Address [1] 0 0
Country [1] 0 0

Ethics approval
Ethics application status

Brief summary
Pain at the front of the knee is a common condition treated by physical therapists. Treatment
may consist of generalised strengthening exercises directed at the quadriceps muscle or
specific retraining aimed at restoring motor control at the knee. This study compared these
two exercise programs in a group of people who were painfree at the time to evaluate their
effect on motor control. It was hypothesised that only the motor retraining program would
influence motor control at the knee.
Trial website
Trial related presentations / publications
Public notes

Principal investigator
Name 0 0
Kim L Bennell, PhD
Address 0 0
University of Melbourne
Country 0 0
Phone 0 0
Fax 0 0
Email 0 0
Contact person for public queries
Name 0 0
Address 0 0
Country 0 0
Phone 0 0
Fax 0 0
Email 0 0
Contact person for scientific queries

Summary results
Other publications