Trial from ANZCTR


Trial ID ACTRN12608000347369
Trial Status: Registered
Date Submitted: 7/07/2008
Date Registered: 22/07/2008
Retrospectively registered

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Public title The Coronary Artery Disease in General Practice Study
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Study title in 'Participant- Intervention- Comparator- Outcome (PICO)' format The prevalence of persistent angina in a primary care setting assessed by a cross-sectional survey
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Secondary ID [1] 624 0
Nil
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UTN
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Trial acronym CADENCE
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Health condition(s) or problem(s) studied:
Chronic Stable Angina 3343 0
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Condition category: Condition code:
Cardiovascular Coronary heart disease
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3496 3496 0 0

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Descriptions of intervention(s) / exposure Cross-sectional survey to identify the prevalence of persistent angina in the Australian primary care setting. General Practitioner's completed a case report form for consecutive patients with a clinical diagnosis of chronic stable angina. The case report form included patient demographics, medical history, medications etc. and took approximately 10 minutes to complete. Each patient completed a modified version of the Seattle Angina Questionnaire, a validated symptom/quality of life instrument. This took approximately 5 minutes to complete. The data was collected prospectively over a period of 6 months.
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Intervention Code:
Not applicable - Observational study 3076 0
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Comparator / control treatment Not applicable - observational study
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Control group Uncontrolled
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Primary Outcome: The prevalance of persistent angina in a primary care setting will be determined using the answers to questions 1 and 2 of the Seattle Angina Questionnaire. 4401 0
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Timepoint: March 2007 4401 0
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Secondary Outcome: Examine predictors of persistent regular angina episodes using the survey data provided and a logistic regression model. 7431 0
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Timepoint: March 2007 7431 0
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Key inclusion criteria Adults >= 18 years old who have ever had a clinical diagnosis of angina pectoris
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Minimum age 18 Years
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Maximum age No limit
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Gender Both males and females
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Healthy volunteers? No
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Key exclusion criteria Inability to read or give informed consent in English
Inability to complete a written questionnaire in English
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Study type Observational
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Patient registry
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Target follow-up duration  
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Purpose Natural history
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Duration Cross-sectional
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Selection Defined population
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Timing Prospective
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Statistical Methods/Analysis
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Phase Not Applicable
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Anticipated date of first participant enrolment 15/09/2006
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Date of first participant enrolment
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Anticipated date last participant recruited/enrolled
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Actual date last participant recruited/enrolled
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Target sample size 3003
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Recruitment status Completed
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Recruitment in Australia

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Recruitment outside Australia

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Funding Source: Commercial sector/Industry 3539 0
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Name: Servier Laboratories 3539 0
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Address: 8 Cato Street
Hawthorn VIC 3122
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Country: Australia 3539 0
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Primary Sponsor Individual
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Name: A/Prof John Beltrame
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Address: The Queen Elizabeth Hospital, Cardiology Unit
University of Adelaide
28 Woodville Rd
Woodville South
SA 5011
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Country: Australia
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Secondary Sponsor: None 3178 0
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Name: 3178 0
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Address: 3178 0
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Country: 3178 0
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Other Collaborator: Commercial sector/Industry 322 0
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Name: Servier Laboratories 322 0
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Address: 8 Cato Street
Hawthorn VIC 3122
322 0
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Country: Australia 322 0
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Has the study received approval from at least one Ethics Committee? Yes
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Ethics Committee name: Royal Australian College of General Practitioners National Research and Evaluation Ethics Committee 5596 0
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Address: 1 Palmerston Crescent
South Melbourne VIC 3205
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Country: Australia 5596 0
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Approval Date: 13/06/2006 5596 0
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Submitted Date: 12/05/2006 5596 0
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HREC: NREEC 06/12 5596 0
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Brief summary This study will assess how a sample group of approximately 3000 angina patients are being managed in Australia.
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Trial website
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Trial related presentations / publications The prevalence of weekly angina among patients with chronic stable angina in primary care practices, Arch Intern Med. 2009;169(16):1491-1499
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Public Notes
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Principal Investigator
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Contact person for public queries
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Name: Dr Andrew Weekes
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Address: 8 Cato Street Hawthorn VIC 3122
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Country: Australia
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Tel: 1800 654 311
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Fax: 03 9822 4190
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Email: andrew.weekes@au.netgrs.com
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Contact person for scientific queries
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Name: Dr Andrew Weekes
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Address: 8 Cato Street Hawthorn VIC 3122
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Country: Australia
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Tel: 1800 654 311
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Fax: 03 9822 4190
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Email: andrew.weekes@au.netgrs.com
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