Trial from ANZCTR


Trial ID ACTRN12608000104358
Trial Status: Registered
Date Submitted: 25/02/2008
Date Registered: 25/02/2008
Retrospectively registered

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Public title THRIVE (Tertiary Health Research Intervention Via Email)
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Study title in 'Participant- Intervention- Comparator- Outcome (PICO)' format For undergraduate university students drinking at harmful and hazardous levels, how effective is 10 minutes of web-based motivational assessment and personalised feedback compared to screening alone in reducing frequency and quantity of alcohol consumption?
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UTN
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Trial acronym THRIVE
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Health condition(s) or problem(s) studied:
Alcohol Consumption 2366 0
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Alcohol-Related Harm 2367 0
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Tobacco Use 2368 0
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Condition category: Condition code:
Public Health Health promotion/education
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2473 2473 0 0
Public Health Health promotion/education
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3002 3002 0 0

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Descriptions of intervention(s) / exposure 10 minutes of web-based motivational assessment and personalised feedback on alcohol consumption versus screening only control followed up at one and six months.
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Intervention Code:
Early detection / Screening 2087 0
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Intervention Code:
Prevention 2088 0
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Intervention Code:
Behaviour 2089 0
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Comparator / control treatment Web-based assessment of drinking only
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Control group Active
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Primary Outcome: Frequency of drinking 3368 0
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Timepoint: At 1 and 6 months after randomization 3368 0
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Primary Outcome: Drinks per typical occasion 3369 0
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Timepoint: At 1 and 6 months after randomization 3369 0
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Primary Outcome: Overall volume of alcohol consumed 3370 0
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Timepoint: At 1 and 6 months after randomization 3370 0
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Secondary Outcome: Frequency of heavy episodes 5587 0
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Timepoint: At 6 months after randomization 5587 0
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Secondary Outcome: Number of personal problems 5588 0
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Timepoint: At 1 and 6 months after randomization 5588 0
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Secondary Outcome: Number of academic problem behaviours 5589 0
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Timepoint: At 1 and 6 months after randomization 5589 0
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Secondary Outcome: Subjective views of intervention effects 5590 0
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Timepoint: At 6 months after randomization 5590 0
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Secondary Outcome: Intervention effect on health seeking behaviour 5591 0
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Timepoint: At 6 months after randomization 5591 0
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Key inclusion criteria Inclusion criteria: full-time enrolment at Curtin University of Technololgy, internal study mode at Bentley campus, recent hazardous drinking: scoring 8+ on the Alcohol Use Disorders Identification Test (AUDIT) and drinking more than 4/6 (females/males) standard drinks on one or more occasions in previous 4 weeks. (Hazardous drinking status assessed via web-based screening questionnaire.)
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Minimum age 17 Years
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Maximum age 25 Years
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Gender Both males and females
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Healthy volunteers? Yes
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Key exclusion criteria Not recent hazardous drinking: scoring 7 or below on the AUDIT and/or not drinking more than 4/6 (females/males) standard drinks on one or more occasions in previous 4 weeks.
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Study type Interventional
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Purpose of the study Prevention
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Allocation to intervention Randomised controlled trial
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Describe the procedure for enrolling a subject and allocating the treatment (allocation concealment procedures) Participants randomly selected from university enrolment database, sent postal and email invitations to complete baseline survey. Those screening positive for hazardous drinking via computer algorithms within the baseline survey were then automatically allocated to intervention or control group via computerised randomisation. Contacted by letter and email at 1 and 6 months to complete follow ups via web-based interface. In accordance with ethics approval, participants were not informed that the study was a RCT.
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Describe the methods used to generate the sequence in which subjects will be randomised (sequence generation) Sequence generation conducted by programmer not involved in implementation of the trial on site (therefore not in contact with study participants) by using a randomisation table created by computer software. Sequence applied automatically by computer algorithms during completion of the baseline survey.
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Masking / blinding Blinded (masking used)
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Who is / are masked / blinded (choose all that apply)


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Assignment Parallel
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Other design features
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Type of endpoint(s) Efficacy
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Statistical Methods/Analysis
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Phase Not Applicable
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Anticipated date of first participant enrolment 5/03/2007
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Date of first participant enrolment
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Anticipated date last participant recruited/enrolled
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Actual date last participant recruited/enrolled
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Target sample size 13000
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Recruitment status Closed: follow-up complete
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Recruitment in Australia

Recruitment state(s)
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Postcode: 6102 431 0
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Recruitment outside Australia

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Funding Source: Government body 2620 0
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Name: Healthway (Western Australian Health Promotion Foundation) 2620 0
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Address: Level 3, 46 Parliament Place
West Perth WA 6005
2620 0
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Country: Australia 2620 0
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Primary Sponsor University
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Name: Western Australian Centre for Health Promotion Research, Curtin University of Technology
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Address: Kent Street
Bentley WA 6102
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Country: Australia
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Secondary Sponsor: None 2369 0
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Name: 2369 0
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Address: 2369 0
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Country: 2369 0
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Has the study received approval from at least one Ethics Committee? Yes
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Ethics Committee name: Curtin University Human Research Ethics Committee 4540 0
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Address: Office of Research and Development
Curtin University of Technology
GPO Box U1987
Perth WA 6845
4540 0
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Country: Australia 4540 0
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Approval Date: 26/01/2006 4540 0
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Submitted Date: 28/11/2005 4540 0
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HREC: 189/2005 4540 0
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Brief summary This study sought to determine the efficacy of universal web-based screening and provision of motivational feedback to reduce hazardous drinking among a university undergraduate student population.
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Trial website
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Trial related presentations / publications
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Public Notes
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Principal Investigator
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Contact person for public queries
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Name: Professor Peter Howat
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Address: Centre for Behavioural Research in Cancer Control Curtin University GPO Box U1987 Perth WA 6845
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Country: Australia
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Tel: +61 8 92661719
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Email: p.howat@curtin.edu.au
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Contact person for scientific queries
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Name: Dr Kypros Kypri
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Address: School of Medicine and Public Health Level 3 David Maddison Clinical Sciences Building University of Newcastle King & Watt Streets Newcastle NSW 2300
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Country: Australia
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Tel: +61 2 4913 8231
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Email: kypros.kypri@newcastle.edu.au
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Contact person responsible for updating information
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Addition Cancer fields
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