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Trial from ANZCTR

Can targeted cognitive training alleviate symptoms of freezing of gait in patients with Parkinson's Disease?

  • Recruitment status at the time of last update
    Active, not recruiting
  • What is the status of the ethics application?
    Ethics status: Approved
  • Prospective – trial registered prior to recruitment of first participant.

    Retrospective – trial registered after recruitment of first participant.
    Retrospectively registered
  • Has the trial been updated in the last 12 months?
    Not up to date
    (Last updated: 22/1/2016)
  • Ethics status: Approved
    What is the status of the ethics application?
  • Not up to date
    Has the trial been updated in the last 6 months?
Key trial Information

Trial ID

ACTRN12613000359730

Date registered

05 April 2013

Health condition

Freezing of Gait in Parkinson's Disease

Recruitment countries

Australia

Recruitment site location(s) (State)

New South Wales

Recruitment status

Active, not recruiting

Anticipated date of first participant enrolment

01 March 2013

Ethics application status

Approved

Brief summary

We will evaluate whether a course of cognitive training can reduce symptoms of FOG in PD. This study will randomize patients into either a 7-week program of cognitive training or a sham control condition. Treatment response will be assessed by video recordings of specific walking tasks (TUG), taken before and after training. In addition, functional brain imaging whilst patients perform a validated virtual reality gait paradigm will be used to determine the brain activation patterns associated with improvements in FOG.

This project will hopefully identify an effective novel treatment for FOG that does not involve pharmacological or surgical intervention. The use of brain imaging will also allow us to see why patients might have differential responses to therapy. Identifying the nature of these relationships will hopefully advance our understanding of freezing and lead to new directions for targeting therapy.

Eligibility

Key inclusion criteria

This study will recruit 100 PD patients with a clinical history of FOG. We aim to recruit participants based on information obtained from medical assessments (including subjective report of symptoms and Mini Mental State Examination (MMSE) score of 24 or greater) as well as self-report measures of freezing (e.g. a positive score on question 3 of the FOG Questionnaire) completed at the PD Research Clinic located at the Brain and Mind Centre.

Minimum age

18 Years

Maximum age

0 No limit

Gender

Both males and females

Key exclusion criteria

MMSE of less than 24

Contact details and further information

Primary Sponsor

Type: Individual
Name: Professor Simon JG Lewis
Address: Brain & Mind Centre
100 Mallett Street,
Camperdown, 2050,
Sydney, New South Wales
Country: Australia

Contact person for information and recruitment

Prof Simon Lewis
Brain & Mind Centre
100 Mallett Street,
Camperdown, 2050,
Sydney, New South Wales
Australia
+61 2 9351 0702
simon.lewis@sydney.edu.au