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Trial registered on ANZCTR

Registration number
Ethics application status
Date submitted
Date registered
Date last updated
Type of registration
Retrospectively registered

Titles & IDs
Public title
The distribution of nutrient sensing abilities in the human gut
Scientific title
An observational study examining the expression of genes involved in taste and nutrient sensing in different regions of the gastrointestinal tract of healthy adults undergoing routine gastroscopy and/or colonoscopy procedures.
Secondary ID [1] 281515 0
Universal Trial Number (UTN)
Trial acronym
Linked study record

Health condition
Health condition(s) or problem(s) studied:
Nutrient sensing 287784 0
Condition category
Condition code
Oral and Gastrointestinal 288135 288135 0 0
Normal oral and gastrointestinal development and function

Study type
Patient registry
Target follow-up duration
Target follow-up type
Description of intervention(s) / exposure
Biopsy samples will be obtained from study participants on one occasion only during a routine gastroscopy and/or colonoscopy procedure.
Intervention code [1] 286034 0
Not applicable
Comparator / control treatment
Control group

Primary outcome [1] 288334 0
Biopsy samples will be analysed using Real-Time quantitative PCR (qPCR) to determine the relative expression of mRNA encoding chemosensory proteins and associated signalling proteins in different regions of the gastrointestinal tract (stomach, small intestine and bowel).
Timepoint [1] 288334 0
Biospy samples (n=10) will be obtained from study participants on one occasion during a routine gastroscopy and/or colonoscopy procedure.
Secondary outcome [1] 299899 0
Tissue and cellular co-localisation of specific sensory proteins and associated signalling proteins will be determined using immunohistochemistry.
Timepoint [1] 299899 0
Biospy samples (n=10) will be obtained from study participants on one occasion during a routine gastroscopy and/or colonoscopy procedure.

Key inclusion criteria
Normal gross gastrointestinal tract anatomy
Generally healthy, as ascertained by self-report
Undergoing gastroscopy and/or colonoscopy examination
Minimum age
18 Years
Maximum age
65 Years
Both males and females
Can healthy volunteers participate?
Key exclusion criteria
Obese as defined by BMI >30kg/m2
Diagnosed diabetes mellitus (type 1 or 2)
Any medical conditions or medications known to affect gut function
Inflammatory or malignant diseases of the gut such as: Inflammatory bowel disease, ischemic bowel, celiac disease etc.
Taking the following medications: NSAIDS, glucocorticoids, immunomodulators, anticoagulants, weight loss medication.
Alcohol or drug dependency.
No extreme food restriction as seen in anorexia nervosa or binge eating plus purging (vomiting/using laxatives) and/or excessive physical activity as seen in bulimia or similar eating disorders that alter body composition in a short space of time
Unwilling/Unable to comply with study protocol
Previous GI tract resection
Participating in another clinical intervention trial

Study design
Natural history
Convenience sample
Statistical methods / analysis

Recruitment status
Date of first participant enrolment
Date of last participant enrolment
Date of last data collection
Sample size
Accrual to date
Recruitment outside Australia
Country [1] 4673 0
New Zealand
State/province [1] 4673 0

Funding & Sponsors
Funding source category [1] 286296 0
Government body
Name [1] 286296 0
Ministry of Business, Innovation & Employment
Address [1] 286296 0
Science and Innovation
Wellington Office
PO Box 5762, Wellington 6145
Country [1] 286296 0
New Zealand
Primary sponsor type
The New Zealand Institute for Plant and Food Research
120 Mt Albert Road
Auckland 1025
New Zealand
Secondary sponsor category [1] 285089 0
Name [1] 285089 0
Waitemata District Health Board
Address [1] 285089 0
Department of Gastroenterology
North Shore Hospital
124 Shakespeare Road
Auckland 0622
Country [1] 285089 0
New Zealand
Other collaborator category [1] 277166 0
Name [1] 277166 0
The University of Auckland
Address [1] 277166 0
Human Nutrition Unit
University of Auckland
18 Carrick Place
Mt Eden
Auckland 1024
Country [1] 277166 0
New Zealand

Ethics approval
Ethics application status
Ethics committee name [1] 288371 0
Northern X Regional Ethics Committee
Ethics committee address [1] 288371 0
Private Bag 92522
Wellesley Street
Auckland 1141
Ethics committee country [1] 288371 0
New Zealand
Date submitted for ethics approval [1] 288371 0
Approval date [1] 288371 0
Ethics approval number [1] 288371 0

Brief summary
Control of appetite is of primary importance in managing body weight and maintaining good health. The human gut plays an important role in controlling food intake by detecting and relaying to the brain changes in the chemical composition of the food as it is digested and absorbed. The gut detects these chemical changes by using a variety of nutrient sensing systems (e.g. nutrient transporters, taste and odorant receptors). The levels of some of these sensory components have been shown to vary across different regions of the gut and may reflect specific sensory abilities at these different sites. We plan to investigate the distribution of these sensory systems in the stomach, small intestine and bowel by obtaining small biopsies of the inner wall of the gut (mucosa) from participants undergoing routine gastroscopy or colonoscopy procedures. By understanding the distribution of these chemosensory systems within the human gut, we hope in the future to be able to design foods that deliver better appetite control.
Trial website
Trial related presentations / publications
Public notes

Principal investigator
Name 34934 0
Address 34934 0
Country 34934 0
Phone 34934 0
Fax 34934 0
Email 34934 0
Contact person for public queries
Name 18181 0
John Ingram
Address 18181 0
Plant and Food Research
Private Bag 92169
Auckland 1142
Country 18181 0
New Zealand
Phone 18181 0
+64 9 9257119
Fax 18181 0
+64 9 9257001
Email 18181 0
Contact person for scientific queries
Name 9109 0
John Ingram
Address 9109 0
Plant and Food Research
Private Bag 92169
Auckland 1142
Country 9109 0
New Zealand
Phone 9109 0
+64 9 9257119
Fax 9109 0
+64 9 9257001
Email 9109 0

No information has been provided regarding IPD availability
Summary results
No Results