The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been endorsed by the ANZCTR. Before participating in a study, talk to your health care provider and refer to this information for consumers
Trial details imported from ClinicalTrials.gov

For full trial details, please see the original record at https://clinicaltrials.gov/show/NCT02993406




Registration number
NCT02993406
Ethics application status
Date submitted
9/12/2016
Date registered
15/12/2016
Date last updated
8/05/2020

Titles & IDs
Public title
Evaluation of Major Cardiovascular Events in Patients With, or at High Risk for, Cardiovascular Disease Who Are Statin Intolerant Treated With Bempedoic Acid (ETC-1002) or Placebo
Scientific title
A Randomized, Double-blind, Placebo-controlled Study to Assess the Effects of Bempedoic Acid (ETC-1002) on the Occurrence of Major Cardiovascular Events in Patients With, or at High Risk for, Cardiovascular Disease Who Are Statin Intolerant
Secondary ID [1] 0 0
1002-043
Universal Trial Number (UTN)
Trial acronym
CLEAR Outcomes
Linked study record

Health condition
Health condition(s) or problem(s) studied:
Cardiovascular Diseases 0 0
Statin Adverse Reaction 0 0
Condition category
Condition code

Intervention/exposure
Study type
Interventional
Description of intervention(s) / exposure
Treatment: Drugs - Bempedoic acid 180 mg tablet
Treatment: Drugs - Matching placebo tablet

Experimental: Bempedoic Acid 180 mg - Bempedoic acid 180 mg tablet taken orally, once daily.

Placebo Comparator: Placebo Comparator - Matching placebo tablet taken orally, once daily


Treatment: Drugs: Bempedoic acid 180 mg tablet
Patients take bempedoic acid 180 mg tablet orally once daily

Treatment: Drugs: Matching placebo tablet
Patients take matching placebo tablet orally once daily

Intervention code [1] 0 0
Treatment: Drugs
Comparator / control treatment
Control group

Outcomes
Primary outcome [1] 0 0
Time from randomization to first occurrence of one of the following adjudicated composite endpoints: CV death, nonfatal myocardial infarction (MI), nonfatal stroke, or coronary revascularization.
Timepoint [1] 0 0
3.75 years (estimated average treatment duration)

Eligibility
Key inclusion criteria
- Age between 18 and 85 years

- History of, or at high risk for, cardiovascular disease (CVD) including coronary
artery disease, symptomatic peripheral arterial disease, cerebrovascular
atherosclerotic disease, or at high risk for a cardiovascular event

- Patient reported history of statin intolerance (inability to tolerate 2 or more
statins, one at a low dose)

- Men and nonpregnant, nonlactating women

- Fasting blood LDL-cholesterol = 100 (2.6 mmol/L) at screening
Minimum age
18 Years
Maximum age
85 Years
Gender
Both males and females
Can healthy volunteers participate?
No
Key exclusion criteria
- Fasting blood triglycerides greater than 500 mg/dL (5.6 mmol/L) at screening

- Recent (within 90 days of screening) history of major cardiovascular events, transient
ischemic attack (TIA), or unstable or symptomatic cardiac arrhythmia

- History of severe heart failure

- Uncontrolled hypertension or uncontrolled diabetes

Study design
Purpose of the study
Treatment
Allocation to intervention
Randomised controlled trial
Procedure for enrolling a subject and allocating the treatment (allocation concealment procedures)
Methods used to generate the sequence in which subjects will be randomised (sequence generation)
Masking / blinding
Blinded (masking used)
Who is / are masked / blinded?
The people receiving the treatment/s

The people assessing the outcomes
The people analysing the results/data
Intervention assignment
Parallel
Other design features
Phase
Phase 3
Type of endpoint(s)
Statistical methods / analysis

Recruitment
Recruitment status
Active, not recruiting
Data analysis
Reason for early stopping/withdrawal
Other reasons
Date of first participant enrolment
Anticipated
Actual
Date of last participant enrolment
Anticipated
Actual
Date of last data collection
Anticipated
Actual
Sample size
Target
Accrual to date
Final
Recruitment in Australia
Recruitment state(s)
NSW,QLD,SA,TAS,VIC,WA
Recruitment hospital [1] 0 0
- Adamstown
Recruitment hospital [2] 0 0
- Camperdown
Recruitment hospital [3] 0 0
- Gosford
Recruitment hospital [4] 0 0
- Liverpool
Recruitment hospital [5] 0 0
- Merewether
Recruitment hospital [6] 0 0
- Tumbi Umbi
Recruitment hospital [7] 0 0
- Wollongong
Recruitment hospital [8] 0 0
- Auchenflower
Recruitment hospital [9] 0 0
- Bundaberg
Recruitment hospital [10] 0 0
- Chermside
Recruitment hospital [11] 0 0
- Milton
Recruitment hospital [12] 0 0
- Sherwood
Recruitment hospital [13] 0 0
- Sippy Downs
Recruitment hospital [14] 0 0
- Woolloongabba
Recruitment hospital [15] 0 0
Royal Adelaide Hospital - Adelaide
Recruitment hospital [16] 0 0
- Adelaide
Recruitment hospital [17] 0 0
- Ashford
Recruitment hospital [18] 0 0
- Fullarton
Recruitment hospital [19] 0 0
- Hobart
Recruitment hospital [20] 0 0
- Ballarat
Recruitment hospital [21] 0 0
- Box Hill
Recruitment hospital [22] 0 0
- Clayton
Recruitment hospital [23] 0 0
- Fitzroy
Recruitment hospital [24] 0 0
- Frankston
Recruitment hospital [25] 0 0
- Langwarrin
Recruitment hospital [26] 0 0
- Melbourne
Recruitment hospital [27] 0 0
- Mildura
Recruitment hospital [28] 0 0
- Joondalup
Recruitment hospital [29] 0 0
- Murdoch
Recruitment hospital [30] 0 0
- Nedlands
Recruitment hospital [31] 0 0
Royal Perth Hospital - Perth
Recruitment hospital [32] 0 0
- Perth
Recruitment hospital [33] 0 0
- Subiaco
Recruitment postcode(s) [1] 0 0
2289 - Adamstown
Recruitment postcode(s) [2] 0 0
2050 - Camperdown
Recruitment postcode(s) [3] 0 0
2250 - Gosford
Recruitment postcode(s) [4] 0 0
2170 - Liverpool
Recruitment postcode(s) [5] 0 0
2291 - Merewether
Recruitment postcode(s) [6] 0 0
2261 - Tumbi Umbi
Recruitment postcode(s) [7] 0 0
2522 - Wollongong
Recruitment postcode(s) [8] 0 0
4066 - Auchenflower
Recruitment postcode(s) [9] 0 0
4670 - Bundaberg
Recruitment postcode(s) [10] 0 0
4032 - Chermside
Recruitment postcode(s) [11] 0 0
4064 - Milton
Recruitment postcode(s) [12] 0 0
4075 - Sherwood
Recruitment postcode(s) [13] 0 0
4556 - Sippy Downs
Recruitment postcode(s) [14] 0 0
4102 - Woolloongabba
Recruitment postcode(s) [15] 0 0
5000 - Adelaide
Recruitment postcode(s) [16] 0 0
5035 - Ashford
Recruitment postcode(s) [17] 0 0
5063 - Fullarton
Recruitment postcode(s) [18] 0 0
7000 - Hobart
Recruitment postcode(s) [19] 0 0
3350 - Ballarat
Recruitment postcode(s) [20] 0 0
3128 - Box Hill
Recruitment postcode(s) [21] 0 0
3168 - Clayton
Recruitment postcode(s) [22] 0 0
3065 - Fitzroy
Recruitment postcode(s) [23] 0 0
3199 - Frankston
Recruitment postcode(s) [24] 0 0
3910 - Langwarrin
Recruitment postcode(s) [25] 0 0
3004 - Melbourne
Recruitment postcode(s) [26] 0 0
3500 - Mildura
Recruitment postcode(s) [27] 0 0
6027 - Joondalup
Recruitment postcode(s) [28] 0 0
6150 - Murdoch
Recruitment postcode(s) [29] 0 0
6009 - Nedlands
Recruitment postcode(s) [30] 0 0
6000 - Perth
Recruitment postcode(s) [31] 0 0
6008 - Subiaco
Recruitment outside Australia
Country [1] 0 0
United States of America
State/province [1] 0 0
Alabama
Country [2] 0 0
United States of America
State/province [2] 0 0
Arizona
Country [3] 0 0
United States of America
State/province [3] 0 0
California
Country [4] 0 0
United States of America
State/province [4] 0 0
Colorado
Country [5] 0 0
United States of America
State/province [5] 0 0
Connecticut
Country [6] 0 0
United States of America
State/province [6] 0 0
Florida
Country [7] 0 0
United States of America
State/province [7] 0 0
Georgia
Country [8] 0 0
United States of America
State/province [8] 0 0
Idaho
Country [9] 0 0
United States of America
State/province [9] 0 0
Illinois
Country [10] 0 0
United States of America
State/province [10] 0 0
Indiana
Country [11] 0 0
United States of America
State/province [11] 0 0
Iowa
Country [12] 0 0
United States of America
State/province [12] 0 0
Kansas
Country [13] 0 0
United States of America
State/province [13] 0 0
Kentucky
Country [14] 0 0
United States of America
State/province [14] 0 0
Louisiana
Country [15] 0 0
United States of America
State/province [15] 0 0
Maryland
Country [16] 0 0
United States of America
State/province [16] 0 0
Massachusetts
Country [17] 0 0
United States of America
State/province [17] 0 0
Michigan
Country [18] 0 0
United States of America
State/province [18] 0 0
Minnesota
Country [19] 0 0
United States of America
State/province [19] 0 0
Mississippi
Country [20] 0 0
United States of America
State/province [20] 0 0
Missouri
Country [21] 0 0
United States of America
State/province [21] 0 0
Montana
Country [22] 0 0
United States of America
State/province [22] 0 0
Nebraska
Country [23] 0 0
United States of America
State/province [23] 0 0
Nevada
Country [24] 0 0
United States of America
State/province [24] 0 0
New Hampshire
Country [25] 0 0
United States of America
State/province [25] 0 0
New Jersey
Country [26] 0 0
United States of America
State/province [26] 0 0
New York
Country [27] 0 0
United States of America
State/province [27] 0 0
North Carolina
Country [28] 0 0
United States of America
State/province [28] 0 0
North Dakota
Country [29] 0 0
United States of America
State/province [29] 0 0
Ohio
Country [30] 0 0
United States of America
State/province [30] 0 0
Oklahoma
Country [31] 0 0
United States of America
State/province [31] 0 0
Pennsylvania
Country [32] 0 0
United States of America
State/province [32] 0 0
Rhode Island
Country [33] 0 0
United States of America
State/province [33] 0 0
South Carolina
Country [34] 0 0
United States of America
State/province [34] 0 0
South Dakota
Country [35] 0 0
United States of America
State/province [35] 0 0
Tennessee
Country [36] 0 0
United States of America
State/province [36] 0 0
Texas
Country [37] 0 0
United States of America
State/province [37] 0 0
Utah
Country [38] 0 0
United States of America
State/province [38] 0 0
Virginia
Country [39] 0 0
United States of America
State/province [39] 0 0
Washington
Country [40] 0 0
United States of America
State/province [40] 0 0
Wisconsin
Country [41] 0 0
Argentina
State/province [41] 0 0
Buenos Aires
Country [42] 0 0
Argentina
State/province [42] 0 0
Ciudad Autonoma Buenos Aires
Country [43] 0 0
Argentina
State/province [43] 0 0
Ciudad Autonoma
Country [44] 0 0
Argentina
State/province [44] 0 0
Cordoba
Country [45] 0 0
Argentina
State/province [45] 0 0
Mendoza
Country [46] 0 0
Argentina
State/province [46] 0 0
Partido De Lomas De Zamora
Country [47] 0 0
Argentina
State/province [47] 0 0
Provincia De Buenos AIres
Country [48] 0 0
Argentina
State/province [48] 0 0
Santa Fe
Country [49] 0 0
Argentina
State/province [49] 0 0
Sante Fe
Country [50] 0 0
Argentina
State/province [50] 0 0
Tucuman
Country [51] 0 0
Argentina
State/province [51] 0 0
Tucumán
Country [52] 0 0
Argentina
State/province [52] 0 0
Ciudad Autonoma de Buenos Aires
Country [53] 0 0
Argentina
State/province [53] 0 0
Ciudad Autónoma de Buenos Aires
Country [54] 0 0
Argentina
State/province [54] 0 0
Corrientes
Country [55] 0 0
Argentina
State/province [55] 0 0
Córdoba
Country [56] 0 0
Argentina
State/province [56] 0 0
La Plata
Country [57] 0 0
Argentina
State/province [57] 0 0
Lanús
Country [58] 0 0
Argentina
State/province [58] 0 0
Morón
Country [59] 0 0
Argentina
State/province [59] 0 0
Pilar
Country [60] 0 0
Argentina
State/province [60] 0 0
Quilmes
Country [61] 0 0
Argentina
State/province [61] 0 0
Ramos Mejía
Country [62] 0 0
Argentina
State/province [62] 0 0
Rosario
Country [63] 0 0
Argentina
State/province [63] 0 0
Salta
Country [64] 0 0
Argentina
State/province [64] 0 0
San Lorenzo
Country [65] 0 0
Argentina
State/province [65] 0 0
San Miguel de Tucuman
Country [66] 0 0
Austria
State/province [66] 0 0
Feldkirch
Country [67] 0 0
Austria
State/province [67] 0 0
Graz
Country [68] 0 0
Austria
State/province [68] 0 0
Innsbruck
Country [69] 0 0
Austria
State/province [69] 0 0
Linz
Country [70] 0 0
Austria
State/province [70] 0 0
Vienna
Country [71] 0 0
Austria
State/province [71] 0 0
Wiener Neustadt
Country [72] 0 0
Austria
State/province [72] 0 0
Wien
Country [73] 0 0
Belgium
State/province [73] 0 0
Aalst
Country [74] 0 0
Belgium
State/province [74] 0 0
Antwerpen
Country [75] 0 0
Belgium
State/province [75] 0 0
Brasschaat
Country [76] 0 0
Belgium
State/province [76] 0 0
Brugge
Country [77] 0 0
Belgium
State/province [77] 0 0
Bruxelles
Country [78] 0 0
Belgium
State/province [78] 0 0
De Pinte
Country [79] 0 0
Belgium
State/province [79] 0 0
Dendermonde
Country [80] 0 0
Belgium
State/province [80] 0 0
Edegem
Country [81] 0 0
Belgium
State/province [81] 0 0
Genk
Country [82] 0 0
Belgium
State/province [82] 0 0
Gent
Country [83] 0 0
Belgium
State/province [83] 0 0
Halen
Country [84] 0 0
Belgium
State/province [84] 0 0
Liège
Country [85] 0 0
Belgium
State/province [85] 0 0
Mechelen
Country [86] 0 0
Belgium
State/province [86] 0 0
Merksem
Country [87] 0 0
Belgium
State/province [87] 0 0
Mons
Country [88] 0 0
Belgium
State/province [88] 0 0
Tienen
Country [89] 0 0
Belgium
State/province [89] 0 0
Turnhout
Country [90] 0 0
Belgium
State/province [90] 0 0
Wetteren
Country [91] 0 0
Belgium
State/province [91] 0 0
Yvoir
Country [92] 0 0
Brazil
State/province [92] 0 0
Bahia
Country [93] 0 0
Brazil
State/province [93] 0 0
Ceará
Country [94] 0 0
Brazil
State/province [94] 0 0
Distrito Federal
Country [95] 0 0
Brazil
State/province [95] 0 0
Espírito Santo
Country [96] 0 0
Brazil
State/province [96] 0 0
Goiás
Country [97] 0 0
Brazil
State/province [97] 0 0
Mato Grosso Do Sul
Country [98] 0 0
Brazil
State/province [98] 0 0
Minas Gerais
Country [99] 0 0
Brazil
State/province [99] 0 0
Paraná
Country [100] 0 0
Brazil
State/province [100] 0 0
Pará
Country [101] 0 0
Brazil
State/province [101] 0 0
Pernambuco
Country [102] 0 0
Brazil
State/province [102] 0 0
Recife
Country [103] 0 0
Brazil
State/province [103] 0 0
Rio Grande Do Norte
Country [104] 0 0
Brazil
State/province [104] 0 0
Rio Grande Do Sul
Country [105] 0 0
Brazil
State/province [105] 0 0
Rio Grande Du Sul
Country [106] 0 0
Brazil
State/province [106] 0 0
Santa Catarina
Country [107] 0 0
Brazil
State/province [107] 0 0
Sao Paulo
Country [108] 0 0
Brazil
State/province [108] 0 0
Sau Paulo
Country [109] 0 0
Brazil
State/province [109] 0 0
São Paulo
Country [110] 0 0
Brazil
State/province [110] 0 0
Bela Vista
Country [111] 0 0
Brazil
State/province [111] 0 0
Belo Horizonte
Country [112] 0 0
Brazil
State/province [112] 0 0
Bento Gonçalves
Country [113] 0 0
Brazil
State/province [113] 0 0
Brasília
Country [114] 0 0
Brazil
State/province [114] 0 0
Curitiba
Country [115] 0 0
Brazil
State/province [115] 0 0
Goiânia
Country [116] 0 0
Brazil
State/province [116] 0 0
Joinville
Country [117] 0 0
Brazil
State/province [117] 0 0
Maceió
Country [118] 0 0
Brazil
State/province [118] 0 0
Marilia
Country [119] 0 0
Brazil
State/province [119] 0 0
Maringá
Country [120] 0 0
Brazil
State/province [120] 0 0
Porto Alegre
Country [121] 0 0
Brazil
State/province [121] 0 0
Rio de Janeiro
Country [122] 0 0
Brazil
State/province [122] 0 0
Salvador
Country [123] 0 0
Brazil
State/province [123] 0 0
Santa Maria
Country [124] 0 0
Brazil
State/province [124] 0 0
São José
Country [125] 0 0
Brazil
State/province [125] 0 0
São Luís
Country [126] 0 0
Bulgaria
State/province [126] 0 0
Blagoevgrad
Country [127] 0 0
Bulgaria
State/province [127] 0 0
Byala
Country [128] 0 0
Bulgaria
State/province [128] 0 0
Dimitrovgrad
Country [129] 0 0
Bulgaria
State/province [129] 0 0
Haskovo
Country [130] 0 0
Bulgaria
State/province [130] 0 0
Pazardzhik
Country [131] 0 0
Bulgaria
State/province [131] 0 0
Pernik
Country [132] 0 0
Bulgaria
State/province [132] 0 0
Pleven
Country [133] 0 0
Bulgaria
State/province [133] 0 0
Plovdiv
Country [134] 0 0
Bulgaria
State/province [134] 0 0
Ruse
Country [135] 0 0
Bulgaria
State/province [135] 0 0
Sandanski
Country [136] 0 0
Bulgaria
State/province [136] 0 0
Sliven
Country [137] 0 0
Bulgaria
State/province [137] 0 0
Sofia
Country [138] 0 0
Bulgaria
State/province [138] 0 0
Stara Zagora
Country [139] 0 0
Bulgaria
State/province [139] 0 0
Varna
Country [140] 0 0
Bulgaria
State/province [140] 0 0
Veliko Tarnovo
Country [141] 0 0
Bulgaria
State/province [141] 0 0
Yambol
Country [142] 0 0
Canada
State/province [142] 0 0
British Columbia
Country [143] 0 0
Canada
State/province [143] 0 0
Newfoundland and Labrador
Country [144] 0 0
Canada
State/province [144] 0 0
Ontario
Country [145] 0 0
Canada
State/province [145] 0 0
Quebec
Country [146] 0 0
Canada
State/province [146] 0 0
Québec
Country [147] 0 0
Chile
State/province [147] 0 0
San Bernardo
Country [148] 0 0
Chile
State/province [148] 0 0
Santiago
Country [149] 0 0
Chile
State/province [149] 0 0
Temuco
Country [150] 0 0
Chile
State/province [150] 0 0
Viña del Mar
Country [151] 0 0
Colombia
State/province [151] 0 0
Barranquilla
Country [152] 0 0
Colombia
State/province [152] 0 0
Bogota
Country [153] 0 0
Colombia
State/province [153] 0 0
Bogotá
Country [154] 0 0
Colombia
State/province [154] 0 0
Bucaramanga
Country [155] 0 0
Colombia
State/province [155] 0 0
Cali
Country [156] 0 0
Colombia
State/province [156] 0 0
Cartagena
Country [157] 0 0
Colombia
State/province [157] 0 0
Espinal
Country [158] 0 0
Colombia
State/province [158] 0 0
Ibagué
Country [159] 0 0
Colombia
State/province [159] 0 0
Manizales
Country [160] 0 0
Colombia
State/province [160] 0 0
Medellin
Country [161] 0 0
Colombia
State/province [161] 0 0
Pereira
Country [162] 0 0
Colombia
State/province [162] 0 0
San Gil
Country [163] 0 0
Colombia
State/province [163] 0 0
Zipaquirá
Country [164] 0 0
Croatia
State/province [164] 0 0
Dubrovnik
Country [165] 0 0
Croatia
State/province [165] 0 0
Koprivnica
Country [166] 0 0
Croatia
State/province [166] 0 0
Krapinske Toplice
Country [167] 0 0
Croatia
State/province [167] 0 0
Opatija
Country [168] 0 0
Croatia
State/province [168] 0 0
Osijek
Country [169] 0 0
Croatia
State/province [169] 0 0
Rijeka
Country [170] 0 0
Croatia
State/province [170] 0 0
Slavonski Brod
Country [171] 0 0
Croatia
State/province [171] 0 0
Varazdin
Country [172] 0 0
Croatia
State/province [172] 0 0
Virovitica
Country [173] 0 0
Croatia
State/province [173] 0 0
Zabok
Country [174] 0 0
Croatia
State/province [174] 0 0
Zadar
Country [175] 0 0
Croatia
State/province [175] 0 0
Zagreb
Country [176] 0 0
Croatia
State/province [176] 0 0
Cakovec
Country [177] 0 0
Czechia
State/province [177] 0 0
Benátky Nad Jizerou
Country [178] 0 0
Czechia
State/province [178] 0 0
Beroun
Country [179] 0 0
Czechia
State/province [179] 0 0
Brandýs Nad Labem
Country [180] 0 0
Czechia
State/province [180] 0 0
Brno
Country [181] 0 0
Czechia
State/province [181] 0 0
Broumov
Country [182] 0 0
Czechia
State/province [182] 0 0
Chocen
Country [183] 0 0
Czechia
State/province [183] 0 0
Chrudim
Country [184] 0 0
Czechia
State/province [184] 0 0
Frýdek-Místek
Country [185] 0 0
Czechia
State/province [185] 0 0
Havirov
Country [186] 0 0
Czechia
State/province [186] 0 0
Havlíckuv Brod
Country [187] 0 0
Czechia
State/province [187] 0 0
Hodonín
Country [188] 0 0
Czechia
State/province [188] 0 0
Hradec Kralove
Country [189] 0 0
Czechia
State/province [189] 0 0
Hradec Králové
Country [190] 0 0
Czechia
State/province [190] 0 0
Kolín
Country [191] 0 0
Czechia
State/province [191] 0 0
Náchod
Country [192] 0 0
Czechia
State/province [192] 0 0
Olomouc
Country [193] 0 0
Czechia
State/province [193] 0 0
Ostrava
Country [194] 0 0
Czechia
State/province [194] 0 0
Pardubice
Country [195] 0 0
Czechia
State/province [195] 0 0
Prague 5
Country [196] 0 0
Czechia
State/province [196] 0 0
Prague
Country [197] 0 0
Czechia
State/province [197] 0 0
Praha 10
Country [198] 0 0
Czechia
State/province [198] 0 0
Praha 1
Country [199] 0 0
Czechia
State/province [199] 0 0
Praha 2
Country [200] 0 0
Czechia
State/province [200] 0 0
Praha 4 - Krc
Country [201] 0 0
Czechia
State/province [201] 0 0
Praha 4
Country [202] 0 0
Czechia
State/province [202] 0 0
Praha
Country [203] 0 0
Czechia
State/province [203] 0 0
Prerov
Country [204] 0 0
Czechia
State/province [204] 0 0
Slaný
Country [205] 0 0
Czechia
State/province [205] 0 0
Teplice
Country [206] 0 0
Czechia
State/province [206] 0 0
Trutnov
Country [207] 0 0
Czechia
State/province [207] 0 0
Uherské Hradište
Country [208] 0 0
Denmark
State/province [208] 0 0
Aalborg
Country [209] 0 0
Denmark
State/province [209] 0 0
Ballerup
Country [210] 0 0
Denmark
State/province [210] 0 0
Copenhagen NV
Country [211] 0 0
Denmark
State/province [211] 0 0
Esbjerg
Country [212] 0 0
Denmark
State/province [212] 0 0
Glostrup
Country [213] 0 0
Denmark
State/province [213] 0 0
Hellerup
Country [214] 0 0
Denmark
State/province [214] 0 0
Holbæk
Country [215] 0 0
Denmark
State/province [215] 0 0
Nykøbing Falster
Country [216] 0 0
Denmark
State/province [216] 0 0
Vejle
Country [217] 0 0
Denmark
State/province [217] 0 0
Viborg
Country [218] 0 0
Denmark
State/province [218] 0 0
Århus N
Country [219] 0 0
Estonia
State/province [219] 0 0
Tallinn
Country [220] 0 0
Germany
State/province [220] 0 0
Baden Wuerttemberg
Country [221] 0 0
Germany
State/province [221] 0 0
Bayern
Country [222] 0 0
Germany
State/province [222] 0 0
Hessen
Country [223] 0 0
Germany
State/province [223] 0 0
Hesse
Country [224] 0 0
Germany
State/province [224] 0 0
Mecklenburg Vorpommern
Country [225] 0 0
Germany
State/province [225] 0 0
Nordrhein Westfalen
Country [226] 0 0
Germany
State/province [226] 0 0
North Rhine-Westphalia
Country [227] 0 0
Germany
State/province [227] 0 0
Rheinland Pfalz
Country [228] 0 0
Germany
State/province [228] 0 0
Sachsen
Country [229] 0 0
Germany
State/province [229] 0 0
Saxony
Country [230] 0 0
Germany
State/province [230] 0 0
Bad Homburg
Country [231] 0 0
Germany
State/province [231] 0 0
Berlin
Country [232] 0 0
Germany
State/province [232] 0 0
Bielefeld
Country [233] 0 0
Germany
State/province [233] 0 0
Falkensee
Country [234] 0 0
Germany
State/province [234] 0 0
Frankfurt
Country [235] 0 0
Germany
State/province [235] 0 0
Hamburg
Country [236] 0 0
Germany
State/province [236] 0 0
Hannover
Country [237] 0 0
Germany
State/province [237] 0 0
Heidelberg
Country [238] 0 0
Germany
State/province [238] 0 0
Mainz
Country [239] 0 0
Germany
State/province [239] 0 0
Reinfeld
Country [240] 0 0
Hungary
State/province [240] 0 0
Szentetornya
Country [241] 0 0
Hungary
State/province [241] 0 0
Baja
Country [242] 0 0
Hungary
State/province [242] 0 0
Balatonfüred
Country [243] 0 0
Hungary
State/province [243] 0 0
Balatongyörök
Country [244] 0 0
Hungary
State/province [244] 0 0
Budapest
Country [245] 0 0
Hungary
State/province [245] 0 0
Békéscsaba
Country [246] 0 0
Hungary
State/province [246] 0 0
Debrecen
Country [247] 0 0
Hungary
State/province [247] 0 0
Dombovar
Country [248] 0 0
Hungary
State/province [248] 0 0
Gyula
Country [249] 0 0
Hungary
State/province [249] 0 0
Gyöngyös
Country [250] 0 0
Hungary
State/province [250] 0 0
Gyor
Country [251] 0 0
Hungary
State/province [251] 0 0
Hajdúszoboszló
Country [252] 0 0
Hungary
State/province [252] 0 0
Kalocsa
Country [253] 0 0
Hungary
State/province [253] 0 0
Kecskemét
Country [254] 0 0
Hungary
State/province [254] 0 0
Kiskunhalas
Country [255] 0 0
Hungary
State/province [255] 0 0
Miskolc
Country [256] 0 0
Hungary
State/province [256] 0 0
Mosonmagyaróvár
Country [257] 0 0
Hungary
State/province [257] 0 0
Nagykanizsa
Country [258] 0 0
Hungary
State/province [258] 0 0
Nyíregyháza
Country [259] 0 0
Hungary
State/province [259] 0 0
Orosháza
Country [260] 0 0
Hungary
State/province [260] 0 0
Polgar
Country [261] 0 0
Hungary
State/province [261] 0 0
Pécs
Country [262] 0 0
Hungary
State/province [262] 0 0
Szekszard
Country [263] 0 0
Hungary
State/province [263] 0 0
Szentendre
Country [264] 0 0
Hungary
State/province [264] 0 0
Szentes
Country [265] 0 0
Hungary
State/province [265] 0 0
Szombathely
Country [266] 0 0
Hungary
State/province [266] 0 0
Székesfehérvár
Country [267] 0 0
Hungary
State/province [267] 0 0
Zalaegerszeg
Country [268] 0 0
India
State/province [268] 0 0
Andhra Pradesh
Country [269] 0 0
India
State/province [269] 0 0
Assam
Country [270] 0 0
India
State/province [270] 0 0
Delhi
Country [271] 0 0
India
State/province [271] 0 0
Gujarat
Country [272] 0 0
India
State/province [272] 0 0
Haryana
Country [273] 0 0
India
State/province [273] 0 0
Karnataka
Country [274] 0 0
India
State/province [274] 0 0
Karnatak
Country [275] 0 0
India
State/province [275] 0 0
Maharashtra
Country [276] 0 0
India
State/province [276] 0 0
Rajasthan
Country [277] 0 0
India
State/province [277] 0 0
Tamilnadu
Country [278] 0 0
India
State/province [278] 0 0
Uttar Pradesh
Country [279] 0 0
India
State/province [279] 0 0
West Bengal
Country [280] 0 0
Latvia
State/province [280] 0 0
Daugavpils
Country [281] 0 0
Latvia
State/province [281] 0 0
Kuldiga
Country [282] 0 0
Latvia
State/province [282] 0 0
Ogre
Country [283] 0 0
Latvia
State/province [283] 0 0
Riga
Country [284] 0 0
Latvia
State/province [284] 0 0
Tukums
Country [285] 0 0
Latvia
State/province [285] 0 0
Ventspils
Country [286] 0 0
Lithuania
State/province [286] 0 0
Alytus
Country [287] 0 0
Lithuania
State/province [287] 0 0
Kaunas
Country [288] 0 0
Lithuania
State/province [288] 0 0
Klaipeda
Country [289] 0 0
Lithuania
State/province [289] 0 0
Vilnius
Country [290] 0 0
Lithuania
State/province [290] 0 0
Šiauliai
Country [291] 0 0
Mexico
State/province [291] 0 0
Baja California Norte
Country [292] 0 0
Mexico
State/province [292] 0 0
Chihuahua C.P.
Country [293] 0 0
Mexico
State/province [293] 0 0
Coahuila
Country [294] 0 0
Mexico
State/province [294] 0 0
Distrito Federal
Country [295] 0 0
Mexico
State/province [295] 0 0
Hidalgo
Country [296] 0 0
Mexico
State/province [296] 0 0
Jalisco
Country [297] 0 0
Mexico
State/province [297] 0 0
Nuevo León
Country [298] 0 0
Mexico
State/province [298] 0 0
Qro.
Country [299] 0 0
Mexico
State/province [299] 0 0
Queretaro
Country [300] 0 0
Mexico
State/province [300] 0 0
Sinaloa
Country [301] 0 0
Mexico
State/province [301] 0 0
Yucatán
Country [302] 0 0
Mexico
State/province [302] 0 0
Aguascalientes
Country [303] 0 0
Mexico
State/province [303] 0 0
Chihuahua
Country [304] 0 0
Mexico
State/province [304] 0 0
Cuernavaca
Country [305] 0 0
Mexico
State/province [305] 0 0
Durango
Country [306] 0 0
Mexico
State/province [306] 0 0
Guadalajara
Country [307] 0 0
Mexico
State/province [307] 0 0
Juarez
Country [308] 0 0
Mexico
State/province [308] 0 0
Mexico City
Country [309] 0 0
Mexico
State/province [309] 0 0
Monterrey
Country [310] 0 0
Mexico
State/province [310] 0 0
Pachuca
Country [311] 0 0
Mexico
State/province [311] 0 0
Puerto Vallarta
Country [312] 0 0
Mexico
State/province [312] 0 0
Querétaro
Country [313] 0 0
Mexico
State/province [313] 0 0
Tamaulipas
Country [314] 0 0
Mexico
State/province [314] 0 0
Veracruz
Country [315] 0 0
Netherlands
State/province [315] 0 0
Alkmaar
Country [316] 0 0
Netherlands
State/province [316] 0 0
Almelo
Country [317] 0 0
Netherlands
State/province [317] 0 0
Almere
Country [318] 0 0
Netherlands
State/province [318] 0 0
Amersfoort
Country [319] 0 0
Netherlands
State/province [319] 0 0
Amstelveen
Country [320] 0 0
Netherlands
State/province [320] 0 0
Amsterdam
Country [321] 0 0
Netherlands
State/province [321] 0 0
Apeldoorn
Country [322] 0 0
Netherlands
State/province [322] 0 0
Arnhem
Country [323] 0 0
Netherlands
State/province [323] 0 0
Beverwijk
Country [324] 0 0
Netherlands
State/province [324] 0 0
Blaricum
Country [325] 0 0
Netherlands
State/province [325] 0 0
Delft
Country [326] 0 0
Netherlands
State/province [326] 0 0
Den Haag
Country [327] 0 0
Netherlands
State/province [327] 0 0
Dirksland
Country [328] 0 0
Netherlands
State/province [328] 0 0
Doetinchem
Country [329] 0 0
Netherlands
State/province [329] 0 0
Dordrecht
Country [330] 0 0
Netherlands
State/province [330] 0 0
Ede
Country [331] 0 0
Netherlands
State/province [331] 0 0
Eindhoven
Country [332] 0 0
Netherlands
State/province [332] 0 0
Enschede
Country [333] 0 0
Netherlands
State/province [333] 0 0
Goes
Country [334] 0 0
Netherlands
State/province [334] 0 0
Gorinchem
Country [335] 0 0
Netherlands
State/province [335] 0 0
Gouda
Country [336] 0 0
Netherlands
State/province [336] 0 0
Hardenberg
Country [337] 0 0
Netherlands
State/province [337] 0 0
Harderwijk
Country [338] 0 0
Netherlands
State/province [338] 0 0
Heerlen
Country [339] 0 0
Netherlands
State/province [339] 0 0
Helmond
Country [340] 0 0
Netherlands
State/province [340] 0 0
Hilversum
Country [341] 0 0
Netherlands
State/province [341] 0 0
Hoogeveen
Country [342] 0 0
Netherlands
State/province [342] 0 0
Hoogezand
Country [343] 0 0
Netherlands
State/province [343] 0 0
Hoorn
Country [344] 0 0
Netherlands
State/province [344] 0 0
Leeuwarden
Country [345] 0 0
Netherlands
State/province [345] 0 0
Leiden
Country [346] 0 0
Netherlands
State/province [346] 0 0
Leiderdorp
Country [347] 0 0
Netherlands
State/province [347] 0 0
Maastricht
Country [348] 0 0
Netherlands
State/province [348] 0 0
Nijmegen
Country [349] 0 0
Netherlands
State/province [349] 0 0
Purmerend
Country [350] 0 0
Netherlands
State/province [350] 0 0
Roosendaal
Country [351] 0 0
Netherlands
State/province [351] 0 0
Rotterdam
Country [352] 0 0
Netherlands
State/province [352] 0 0
Schiedam
Country [353] 0 0
Netherlands
State/province [353] 0 0
Sneek
Country [354] 0 0
Netherlands
State/province [354] 0 0
Tiel
Country [355] 0 0
Netherlands
State/province [355] 0 0
Tilburg
Country [356] 0 0
Netherlands
State/province [356] 0 0
Utrecht
Country [357] 0 0
Netherlands
State/province [357] 0 0
Venlo
Country [358] 0 0
Netherlands
State/province [358] 0 0
Zutphen
Country [359] 0 0
Netherlands
State/province [359] 0 0
Zwijndrecht
Country [360] 0 0
Netherlands
State/province [360] 0 0
Zwolle
Country [361] 0 0
New Zealand
State/province [361] 0 0
Auckland
Country [362] 0 0
New Zealand
State/province [362] 0 0
Christchurch
Country [363] 0 0
New Zealand
State/province [363] 0 0
Grafton
Country [364] 0 0
New Zealand
State/province [364] 0 0
Hamilton
Country [365] 0 0
New Zealand
State/province [365] 0 0
Hastings
Country [366] 0 0
New Zealand
State/province [366] 0 0
New Plymouth
Country [367] 0 0
New Zealand
State/province [367] 0 0
Papamoa
Country [368] 0 0
New Zealand
State/province [368] 0 0
Rotorua
Country [369] 0 0
New Zealand
State/province [369] 0 0
Tauranga
Country [370] 0 0
New Zealand
State/province [370] 0 0
Wellington
Country [371] 0 0
Poland
State/province [371] 0 0
Dolnoslaskie
Country [372] 0 0
Poland
State/province [372] 0 0
Kujawsko-Pomorskie
Country [373] 0 0
Poland
State/province [373] 0 0
Lubelski
Country [374] 0 0
Poland
State/province [374] 0 0
Malopolskie
Country [375] 0 0
Poland
State/province [375] 0 0
Slaskie
Country [376] 0 0
Poland
State/province [376] 0 0
Bialystok
Country [377] 0 0
Poland
State/province [377] 0 0
Brzozów
Country [378] 0 0
Poland
State/province [378] 0 0
Bydgoszcz
Country [379] 0 0
Poland
State/province [379] 0 0
Chelm
Country [380] 0 0
Poland
State/province [380] 0 0
Czestochowa
Country [381] 0 0
Poland
State/province [381] 0 0
Elblag
Country [382] 0 0
Poland
State/province [382] 0 0
Gdansk
Country [383] 0 0
Poland
State/province [383] 0 0
Gdynia
Country [384] 0 0
Poland
State/province [384] 0 0
Grodzisk Mazowiecki
Country [385] 0 0
Poland
State/province [385] 0 0
Katowice
Country [386] 0 0
Poland
State/province [386] 0 0
Kielce
Country [387] 0 0
Poland
State/province [387] 0 0
Krakow
Country [388] 0 0
Poland
State/province [388] 0 0
Kraków
Country [389] 0 0
Poland
State/province [389] 0 0
Legnica
Country [390] 0 0
Poland
State/province [390] 0 0
Lublin
Country [391] 0 0
Poland
State/province [391] 0 0
Naleczów
Country [392] 0 0
Poland
State/province [392] 0 0
Nowa Sól
Country [393] 0 0
Poland
State/province [393] 0 0
Nowy Targ
Country [394] 0 0
Poland
State/province [394] 0 0
Oswiecim
Country [395] 0 0
Poland
State/province [395] 0 0
Poznan
Country [396] 0 0
Poland
State/province [396] 0 0
Pulawy
Country [397] 0 0
Poland
State/province [397] 0 0
Plock
Country [398] 0 0
Poland
State/province [398] 0 0
Ruda Slaska
Country [399] 0 0
Poland
State/province [399] 0 0
Rzeszów
Country [400] 0 0
Poland
State/province [400] 0 0
Siedlce
Country [401] 0 0
Poland
State/province [401] 0 0
Skierniewice
Country [402] 0 0
Poland
State/province [402] 0 0
Sopot
Country [403] 0 0
Poland
State/province [403] 0 0
Staszów
Country [404] 0 0
Poland
State/province [404] 0 0
Szczecin
Country [405] 0 0
Poland
State/province [405] 0 0
Tarnów
Country [406] 0 0
Poland
State/province [406] 0 0
Tczew
Country [407] 0 0
Poland
State/province [407] 0 0
Torun
Country [408] 0 0
Poland
State/province [408] 0 0
Warsaw
Country [409] 0 0
Poland
State/province [409] 0 0
Warszawa
Country [410] 0 0
Poland
State/province [410] 0 0
Wroclaw
Country [411] 0 0
Poland
State/province [411] 0 0
Wloclawek
Country [412] 0 0
Poland
State/province [412] 0 0
Zamosc
Country [413] 0 0
Poland
State/province [413] 0 0
Lódz
Country [414] 0 0
Romania
State/province [414] 0 0
Arges
Country [415] 0 0
Romania
State/province [415] 0 0
Maramures County
Country [416] 0 0
Romania
State/province [416] 0 0
Satu Mare County
Country [417] 0 0
Romania
State/province [417] 0 0
Timis County
Country [418] 0 0
Romania
State/province [418] 0 0
Alba Iulia
Country [419] 0 0
Romania
State/province [419] 0 0
Baia Mare
Country [420] 0 0
Romania
State/province [420] 0 0
Balotesti
Country [421] 0 0
Romania
State/province [421] 0 0
Braila
Country [422] 0 0
Romania
State/province [422] 0 0
Brasov
Country [423] 0 0
Romania
State/province [423] 0 0
Bucharest
Country [424] 0 0
Romania
State/province [424] 0 0
Bucuresti
Country [425] 0 0
Romania
State/province [425] 0 0
Calarasi
Country [426] 0 0
Romania
State/province [426] 0 0
Cluj-Napoca
Country [427] 0 0
Romania
State/province [427] 0 0
Craiova
Country [428] 0 0
Romania
State/province [428] 0 0
Deva
Country [429] 0 0
Romania
State/province [429] 0 0
Galati
Country [430] 0 0
Romania
State/province [430] 0 0
Oradea
Country [431] 0 0
Romania
State/province [431] 0 0
Pascani
Country [432] 0 0
Romania
State/province [432] 0 0
Pitesti
Country [433] 0 0
Romania
State/province [433] 0 0
Ploiesti
Country [434] 0 0
Romania
State/province [434] 0 0
Satu Mare
Country [435] 0 0
Romania
State/province [435] 0 0
Timisoara
Country [436] 0 0
Romania
State/province [436] 0 0
Târgu-Mures
Country [437] 0 0
Romania
State/province [437] 0 0
Zalau
Country [438] 0 0
Russian Federation
State/province [438] 0 0
Altayskiy Kray
Country [439] 0 0
Russian Federation
State/province [439] 0 0
Arkhangel'sk
Country [440] 0 0
Russian Federation
State/province [440] 0